CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM4444
Family Name Melatonin receptor type 1A and Melatonin receptor type 1C ligand N-[(6-chloro-9-methyl-1,2,3,4-tetrahydrocarbazol-4-yl)methyl]acetamide family
No. of Seeds 2 No. of Other Members 5
Family Centroid CFAMM00356133 Functional Category Bioactive with Natural Product
Superfamily D(2) dopamine receptor Ligand Sertindole Superfamily
Class Class 471

Cousin Family NamesSeedsMembers
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 14 2769
D(1A) dopamine receptor ligand ergot alkaloid Methylergonovine... 22 170
D(2) dopamine receptor Ligand Sertindole Family 3 173
Glycogen phosphorylase, muscle form Inhibitor PSN357 Family 3 253
Receptor-type tyrosine-protein kinase FLT3 Inhibitor SU5614 Fa... 4 36
Poly [ADP-ribose] polymerase 1 Inhibitor AG-14699 Family 13 179
Reverse transcriptase Inhibitor IDX899 Family 2 118
Growth hormone receptor Ligand EP-51216 Family 34 390
D(1B) dopamine receptor Ligand LE-300 Family 65 452
Histone deacetylase 1 Inhibitor Panobinostat Family 5 93
Neuropeptide Y receptor type 5 Ligand Npy5ra-972 Family 6 29
Lethal factor Inhibitor GM6001 Family 50 435
Nicotinic acetylcholine receptor Ligand Epibatidine Family 36 19
Fibroblast growth factor receptor 2 Ligand Interferon Alfa (if... 14 162
5-hydroxytryptamine receptor 2B Ligand Sb 206553 Family 14 21
D(2) dopamine receptor and D(3) dopamine receptor Ligand 4-(4-... 6 48
Potassium voltage-gated channel subfamily H member 2 Ligand 5-... 5 14
5-hydroxytryptamine receptor 2A Ligand 8-chloro-1,2,3,4-tetrah... 5 4
Cannabinoid receptor 2 Ligand JWH-204 Family 6 10
Acetylcholinesterase and Cholinesterase Inhibitor Lipocrine Fa... 18 36
Acetylcholinesterase and Cholinesterase Inhibitor Huprine-tacr... 43 17
Cholecystokinin receptor type A Ligand VL-0395 Family 12 117
Inosine-5'-monophosphate dehydrogenase 2 Inhibitor 1-methyl-1h... 6 24
Mineralocorticoid receptor and Androgen receptor Ligand WAY-25... 10 26
14-alpha sterol demethylase Inhibitor CP-320626 Family 13 76
Cytochrome P450 11B1, mitochondrial and Aromatase Inhibitor 5-... 4 10
Kappa-type opioid receptor and Mu-type opioid receptor Ligand ... 19 108
Sodium-dependent serotonin transporter Inhibitor 3-(3-aminocyc... 94 23
5-hydroxytryptamine receptor 2A and Amine oxidase [flavin-cont... 10 18
Gamma-aminobutyric acid receptor subunit alpha-1 Ligand 3-chlo... 3 2
Acetylcholinesterase and Cholinesterase Inhibitor Huprine-tacr... 62 27
Substance-P receptor ligand AGN-PC-01ZIXQ family 13 42
Huntingtin and Glycogen synthase kinase-3 beta inhibitor SB 21... 2 4
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 2 1
Caspase-1 inhibitor (3S)-3-[[(2S)-4-[2-(1,2-dimethylindol-3-yl... 3 4
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 11 20
Sodium-dependent serotonin transporter inhibitor SureCN6087392... 1 1
Melanin-concentrating hormone receptor 1 ligand AGN-PC-072CVE ... 4 4
Melanin-concentrating hormone receptor 1 ligand AGN-PC-09M6QF ... 3 0
Translocator protein inhibitor (2E)-N-(4-chlorophenyl)-N-methy... 2 13
D(4) dopamine receptor and D(1A) dopamine receptor ligand 2-[[... 5 4
D(2) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 5 8
Neuropeptide Y receptor type 5 ligand 2-(6-chloroindol-1-yl)-N... 4 23
cGMP-specific 3',5'-cyclic phosphodiesterase and Dual 3',5'-cy... 4 129
Ceramide glucosyltransferase inhibitor AGN-PC-07YS0C family 4 3
Dipeptidyl peptidase 4 inhibitor AGN-PC-09QKOM family 5 8
Sodium-dependent serotonin transporter and Sodium-dependent no... 5 3
Melanin-concentrating hormone receptor 2 ligand N-[(1R)-1'-(9H... 4 1
Melanin-concentrating hormone receptor 2 and Sodium-dependent ... 2 1
Translocator protein inhibitor N,N-diethyl-11-(2-fluoroethyl)-... 14 9
Acetylcholinesterase and Cholinesterase inhibitor AGN-PC-009GH... 8 10
Neuropeptide Y receptor type 5 ligand 2-indol-1-yl-N-[4-[(prop... 7 6
Histone deacetylase 6 and Histone deacetylase 1 inhibitor 4-[(... 2 9
Substance-P receptor ligand SureCN7796965 family 9 1
Melanin-concentrating hormone receptor 1 ligand SureCN4261878 ... 4 7
Cathepsin K inhibitor (1R,2R)-2-(6-chloro-1,3,4,5-tetrahydropy... 2 0
Cathepsin K and Cathepsin B inhibitor (1R,2R)-N-(1-cyanocyclop... 10 7
5-hydroxytryptamine receptor 6 ligand 9-(2-bromophenyl)sulfony... 2 0
Prostaglandin D2 receptor 2 ligand 2-[3-[(3-chlorophenyl)-meth... 1 0
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand AGN-P... 8 6
Gonadotropin-releasing hormone receptor ligand 1-adamantyl-[2-... 3 1
Somatostatin receptor type 1 and Somatostatin receptor type 2 ... 3 5
C-C chemokine receptor type 2 ligand (E)-3-(3,4-dichlorophenyl... 3 2
Melatonin receptor type 1A and Melatonin receptor type 1C liga... 1 0
Poly [ADP-ribose] polymerase 1 inhibitor SureCN4998361 family 1 1
Translocator protein inhibitor N,N-dibutyl-2-(7-chloro-2-pheny... 3 1
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 2 1
Translocator protein inhibitor 2-(7-Chloro-5-methyl-4-oxo-3-ph... 1 0
5-hydroxytryptamine receptor 7 ligand AGN-PC-00PFK0 family 1 0
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 1 1
Metabotropic glutamate receptor 5 ligand [2-[6-(3-chlorophenyl... 1 2
Integrin beta-2 and Intercellular adhesion molecule 1 inhibito... 2 2
Potassium voltage-gated channel subfamily A member 5 and Volta... 2 4


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00356133 CHEMBL141146 Bioactive N-[(6-chloro-9-methyl-1,2,3,4-tetrahydrocarbazol-4-yl)methyl]acetamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27523 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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