CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM446
Family Name Serine/threonine-protein kinase B-raf inhibitor AGN-PC-072YMN family
No. of Seeds 7 No. of Other Members 11
Family Centroid CFAMM00311640 Functional Category Bioactive
Superfamily B-lymphocyte antigen CD20 Inhibitor Iodine-131-tositumomab Superfamily
Class Class 795

Cousin Family NamesSeedsMembers
Corticotropin-releasing factor receptor 1 Ligand CRF-1 Antagon... 29 421
Corticotropin-releasing factor receptor 1 Ligand GW876008 Family 3 30
Hepatocyte growth factor receptor Ligand Amg 208 Family 20 236
Peptide deformylase, mitochondrial Inhibitor Epiroprim Family 5 68
Tyrosine kinase Inhibitor PKI166 Family 17 198
Vascular endothelial growth factor receptor 2 Ligand L00002164... 6 23
Cyclin-dependent kinase 2 and Cyclin-dependent kinase 4 Inhibi... 19 48
Glycogen synthase kinase-3 beta and Mitogen-activated protein ... 8 8
AMP-activated protein kinase Inhibitor 4-(3-bromopyrazolo[1,5-... 1 8
Serine/threonine-protein kinase B-raf inhibitor SureCN1015955 ... 17 18
Serine/threonine-protein kinase B-raf inhibitor SureCN1013580 ... 2 0
Serine/threonine-protein kinase B-raf inhibitor 3-[7-[4-[[(3R)... 6 7
Serine/threonine-protein kinase B-raf inhibitor AGN-PC-072YXQ ... 2 1
Proto-oncogene tyrosine-protein kinase Src and Cyclin-dependen... 2 1
Adenosine receptor A3 ligand CHEMBL1834696 family 5 18
Epidermal growth factor receptor and Tyrosine-protein kinase A... 4 3
Serine/threonine-protein kinase Chk2 and Serine/threonine-prot... 3 6
Tyrosine-protein kinase ABL1 and Tyrosine-protein kinase HCK i... 2 2
Tyrosine-protein kinase HCK and Proto-oncogene tyrosine-protei... 5 9
Proto-oncogene tyrosine-protein kinase Src and Tyrosine-protei... 12 8
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor SureCN7... 3 0
Tyrosine-protein kinase JAK2 inhibitor 5-(3-methoxyphenyl)-N-[... 2 11
Proto-oncogene tyrosine-protein kinase Src and Epidermal growt... 9 9
Calmodulin-domain protein kinase 1 and Tyrosine-protein kinase... 5 5
TGF-beta receptor type-1 ligand N-(4-methoxyphenyl)-3-(6-methy... 5 2
Receptor-type tyrosine-protein kinase FLT3 and Mast/stem cell ... 1 6
Tyrosine-protein kinase JAK2 and Focal adhesion kinase 1 inhib... 3 1
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 8 2
Hepatocyte growth factor receptor and Cytochrome P450 3A4 liga... 5 2
Fibroblast growth factor receptor 1 and Vascular endothelial g... 3 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 3 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 2 5
Histamine H3 receptor and Potassium voltage-gated channel subf... 1 0
Histone-arginine methyltransferase CARM1 inhibitor AGN-PC-00HE... 4 4
cGMP-dependent 3',5'-cyclic phosphodiesterase inhibitor SureCN... 4 0
Tyrosine-protein kinase JAK2 inhibitor (2R)-2-[4-[[8-(4-methox... 2 0
Hepatocyte growth factor receptor ligand 6-[(1S)-1-[6-(2,3-dih... 1 5
Cyclin-dependent kinase 1 and Receptor tyrosine-protein kinase... 2 3
Oxytocin receptor and Vasopressin V1a receptor ligand AGN-PC-0... 4 3
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 2 0
Serine/threonine-protein kinase B-raf inhibitor AGN-PC-07CQG5 ... 2 1
Acyl-CoA desaturase 1 and Acyl-CoA desaturase inhibitor AGN-PC... 2 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00311633 CHEMBL570873 Bioactive SureCN4051866
CFAMM00311643 CHEMBL585148 Bioactive SureCN4048706
CFAMM00311636 CHEMBL1080833 Bioactive AGN-PC-072YXR
CFAMM00311642 CHEMBL578391 Bioactive AGN-PC-072YGY
CFAMM00311635 CHEMBL569081 Bioactive AGN-PC-072YGX
CFAMM00311640 CHEMBL571130 Bioactive AGN-PC-072YMN
CFAMM00311638 CHEMBL570431 Bioactive AGN-PC-072YGW

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

21767 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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