CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM4472
Family Name Adenosine kinase inhibitor N-cyclopropyl-2-[[1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-3-phenylpyrazolo[3,4-d]pyrimidin-4-yl]amino]acetamide family
No. of Seeds 4 No. of Other Members 1
Family Centroid CFAMM00356397 Functional Category Bioactive
Superfamily Adenosine receptor A1 and Adenosine receptor A2a Binder Superfamily 4
Class Class 652

Cousin Family NamesSeedsMembers
Pigment epithelium-derived factor Inhibitor Adpedr Family 2 112
Adenosine receptor A3 Ligand CF101 Family 24 560
Adenosine receptor A2a Ligand MRE-0094 Family 10 108
Aurora kinase B and Aurora kinase C Inhibitor GSK1070916 Family 53 580
Cyclin-dependent kinase 1 and Cyclin-dependent kinase 2 Inhibi... 1 2
GP-531 family 1 33
C-Jun N-terminal kinase Inhibitor CC-930 Family 2 9
Corticotropin-releasing factor receptor 1 Ligand R121919 Family 26 84
Equilibrative nucleoside/nucleobase transporter Inhibitor Nitr... 23 98
Poly [ADP-ribose] polymerase 1 Inhibitor EB-47 Family 17 41
Amine oxidase [flavin-containing] A and Amine oxidase [flavin-... 2 7
Adenosine receptor A1 and Adenosine receptor A2a Ligand N6-met... 7 72
Adenosine receptor A1 and Adenosine receptor A2a Ligand GW-328... 26 94
Adenosine receptor A1 and Adenosine receptor A2a Ligand N6-met... 21 57
Adenosine receptor A1 and Adenosine receptor A2a Ligand 2-[(4-... 15 9
Adenosine receptor A1 and Adenosine receptor A2a Ligand 2-(3''... 12 5
Adenosine receptor A1 and Adenosine receptor A2a Ligand 2-(3''... 2 2
Adenosine receptor A1 and Adenosine receptor A2a Ligand 2-(3''... 2 3
Adenosine receptor A2a and Adenosine receptor A3 Ligand 2-(3''... 8 10
Inositol 1,4,5-trisphosphate receptor type 3 Ligand 5'-deoxy-5... 11 8
Adenosine kinase inhibitor GP683 family 12 7
Mitogen-activated protein kinase 8 and Mitogen-activated prote... 2 5
Adenosine receptor A3 and Adenosine receptor A1 ligand (2R,3S,... 1 2
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 4 1
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 14 13
G1/S-specific cyclin-E1 and Cyclin-dependent kinase 2 inhibito... 1 5
Adenosine receptor A3 and Adenosine receptor A2a ligand (1R,2R... 12 17
Receptor-type tyrosine-protein kinase FLT3 and Mast/stem cell ... 2 3
Adenosine receptor A1 ligand N-[(2R,3R,4R,5R)-5-[6-(cyclopenty... 3 2
Adenosine kinase inhibitor (2R,3R,4R)-2-[4-(2,3-dihydro-1,4-be... 5 2
Adenosine kinase inhibitor 2-[[7-[(2R,3R,4S,5R)-3,4-dihydroxy-... 15 0
Adenosine kinase inhibitor SureCN8320660 family 7 2
Adenosine receptor A3 and Adenosine receptor A1 ligand (2S,3S,... 8 10
Tyrosine-protein kinase Mer and Tyrosine-protein kinase recept... 5 3
Activated CDC42 kinase 1 inhibitor N,N-dimethyl-4-[4-[[(2S)-ox... 4 2
Adenosine receptor A3 and Adenosine receptor A1 ligand (2S,3S,... 2 10
Adenosine receptor A1 and Adenosine receptor A3 ligand N-benzy... 4 2
Adenosine receptor A1 ligand 2-[4-[[2-[4-[[9-[(3R,4S,5R)-3,4-d... 14 0
Tyrosine-protein kinase JAK2 inhibitor [4-[[5-(1-ethylpyrazol-... 2 3
Adenosine receptor A1 ligand 3-chloro-N-[(2S,3R,4R,5R)-5-[6-(c... 1 0
Adenosine receptor A1 ligand (2,5-dioxopyrrolidin-1-yl) 2-[4-[... 3 0
Activated CDC42 kinase 1 inhibitor AGN-PC-078WDN family 7 2
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 26 0
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 12 0
Equilibrative nucleoside transporter 1 inhibitor N-[6-[2-[[(2S... 2 0
Adenosine receptor A2a and Adenosine receptor A3 ligand SureCN... 4 3
Adenosine receptor A1 ligand 2-[4-[[2-[4-[[9-[(3R,4S,5R)-3,4-d... 1 0
78 kDa glucose-regulated protein inhibitor 4-[[(2R,3S,4R,5R)-5... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00356397 CHEMBL200457 Bioactive N-cyclopropyl-2-[[1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-3-phenylpyrazolo[3,4-d]pyrimidin-4-yl]amino]acetamide
CFAMM00356396 CHEMBL198566 Bioactive 2-[[1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-3-phenylpyrazolo[3,4-d]pyrimidin-4-yl]amino]-N-phenylacetamide
CFAMM00356395 CHEMBL436096 Bioactive N-cyclopropyl-2-[[1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-methyloxolan-2-yl]-3-phenylpyrazolo[3,4-d]pyrimidin-4-yl]amino]acetamide
CFAMM00356394 CHEMBL141327 Bioactive SureCN8328727

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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