CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM4485
Family Name Thyroid hormone receptor beta and Ferritin light chain ligand CHEMBL1414179 family
No. of Seeds 1 No. of Other Members 35
Family Centroid CFAMM00356476 Functional Category Bioactive
Superfamily Renin and Insulin-like growth factor 1 receptor Binder Superfamily
Class Class 1070

Cousin Family NamesSeedsMembers
Histamine H1 receptor Ligand Astemizole Family 7 240
Histamine H1 receptor Ligand Mepyramine Family 5 65
Serine/threonine-protein kinase PLK1 Inhibitor Bi 6727 Family 15 81
Corticotropin-releasing factor receptor 1 Ligand CRF-1 Antagon... 29 421
Gamma-secretase subunit APH-1B Inhibitor E2012 Family 3 67
Adenosine receptor A2a Ligand KW-6002 Family 18 195
Receptor tyrosine-protein kinase erbB-2 Inhibitor CP-724714 Fa... 4 180
Insulin-like growth factor 1 receptor Ligand AEW-541 Family 12 140
Calcium-activated potassium channel subunit alpha-1 Ligand AVE... 3 284
Corticotropin-releasing factor receptor 1 Ligand GW876008 Family 3 30
DCC-2036 family 2 5
Smoothened homolog Inhibitor LDE225 Family 3 76
SB1518 family 7 103
Hepatocyte growth factor receptor Ligand Amg 208 Family 20 236
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 11 10
RAF proto-oncogene serine/threonine-protein kinase Inhibitor R... 7 148
DNA Binder Bisbenzimide (hoechst 33258) Family 4 159
Peptide deformylase, mitochondrial Inhibitor Epiroprim Family 5 68
Tyrosine kinase Inhibitor PKI166 Family 17 198
5-hydroxytryptamine receptor 1A Ligand P-MPPI Family 33 81
Heat shock protein HSP 90-alpha Inhibitor 8-benzo[1,3]dioxol-,... 5 83
Cyclin-dependent kinase 2 and Cyclin-dependent kinase 9 Inhibi... 10 35
D(2) dopamine receptor and D(3) dopamine receptor Ligand [2-(1... 17 100
Cytochrome P450 2D6 and Cytochrome P450 3A4 Inhibitor 2-[3-(4-... 7 128
Cyclin-dependent kinase 2 and Cyclin-dependent kinase 4 Inhibi... 19 48
Adenosine receptor A1 and Adenosine receptor A3 Ligand 2-(4-me... 3 23
DNA-dependent protein kinase catalytic subunit Inhibitor 8-(1h... 3 85
Glycogen synthase kinase-3 beta and Mitogen-activated protein ... 8 8
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 50 17
C-X-C chemokine receptor type 3 Ligand AMG-487 Family 28 73
Fatty-acid amide hydrolase 1 Inhibitor BMS-1 Family 5 22
5-hydroxytryptamine receptor 2C Ligand N-(6-phenoxypyridin-3-y... 9 69
Adenosine receptor A1 and Adenosine receptor A2a Ligand N-(2-(... 21 108
Nitric oxide synthase, inducible and Nitric oxide synthase, br... 2 3
Gamma-aminobutyric acid receptor subunit alpha-1 Ligand Divapl... 3 47
Reverse transcriptase Inhibitor Atevirdine Family 4 55
Reverse transcriptase Inhibitor UK-129485 Family 23 221
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 17 49
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 10 46
Metabotropic glutamate receptor 5 Ligand 3-methoxy-n-(6-methyl... 3 15
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 18 72
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 13 15
Liver carboxylesterase 1 Inhibitor SM-32504 Family 3 28
cGMP-specific 3',5'-cyclic phosphodiesterase Inhibitor SK&F-96... 5 83
Integrin beta-3 and Integrin alpha-V inhibitor methyl (3S)-3-(... 12 13
Cyclin-dependent kinase 2 and Cyclin-dependent kinase 1 inhibi... 2 22
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 3 4
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 6 35
Tyrosine-protein kinase Lck inhibitor 4-N-(2-chloro-6-methylph... 8 45
Serine/threonine-protein kinase B-raf inhibitor SureCN1015955 ... 17 18
Tyrosine-protein kinase JAK3 and Tyrosine-protein kinase JAK2 ... 2 6
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 2 28
Vascular endothelial growth factor receptor 2 and Angiopoietin... 2 11
Histamine H4 receptor ligand AGN-PC-07ZG9H family 4 4
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 6 11
Adenosine receptor A3 ligand AGN-PC-07N4XZ family 4 11
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 9 3
Sphingosine 1-phosphate receptor 1 and Sphingosine 1-phosphate... 7 16
Mitogen-activated protein kinase 14 inhibitor N-(4-aminobutyl)... 1 28
Serine/threonine-protein kinase PLK1 and Serine/threonine-prot... 14 42
Hepatocyte growth factor receptor and Receptor-type tyrosine-p... 12 26
Adenosine receptor A3 ligand CHEMBL1834696 family 5 18
Beta-1 adrenergic receptor and Beta-2 adrenergic receptor liga... 4 18
Beta-1 adrenergic receptor and Beta-2 adrenergic receptor liga... 6 7
Gonadotropin-releasing hormone receptor ligand 1-[(2,6-difluor... 6 31
Protein farnesyltransferase subunit beta and Protein farnesylt... 3 0
Muscarinic acetylcholine receptor M2 and Muscarinic receptor 3... 4 3
Tyrosine-protein kinase ABL1 inhibitor AGN-PC-04S3QV family 1 2
Lysine--tRNA ligase and Dual specificity protein kinase CLK4 i... 4 27
cGMP-inhibited 3',5'-cyclic phosphodiesterase B and cGMP-inhib... 39 10
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 8 inhibitor Su... 2 16
Cathepsin S and Cathepsin K inhibitor SureCN1629664 family 10 11
Cathepsin S and Cathepsin K inhibitor AGN-PC-07YOWS family 4 6
Adenosine kinase inhibitor 5-[3-(4-methoxyphenyl)propyl]-6-[2-... 2 11
Aurora kinase A inhibitor SureCN761545 family 2 2
Type-1 angiotensin II receptor and Type-2 angiotensin II recep... 10 54
Type-1 angiotensin II receptor and Type-2 angiotensin II recep... 7 0
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 9 19
Angiopoietin-1 receptor and Aurora kinase B ligand SureCN12658... 3 19
Vascular endothelial growth factor receptor 2 ligand AGN-PC-09... 5 11
Glucocorticoid receptor ligand (2R)-1,1,1-trifluoro-4-(2-metho... 2 5
Amine oxidase [flavin-containing] A and Amine oxidase [flavin-... 2 1
Translocator protein inhibitor AGN-PC-080ILF family 9 3
Casein kinase I isoform delta and Mitogen-activated protein ki... 3 18
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor SureCN6... 19 11
Dual specificity protein kinase CLK1 and Dual specificity prot... 2 14
DNA-(apurinic or apyrimidinic site) lyase and Retinal dehydrog... 1 3
Translocator protein inhibitor SureCN6906757 family 3 2
Prelamin-A/C and Nuclear receptor ROR-gamma ligand CHEMBL13704... 1 7
Survival motor neuron protein inhibitor CHEMBL1379159 family 1 10
Melatonin receptor type 1A ligand N-[2-(5-methoxy-2-phenyl-1H-... 1 2
Cellular tumor antigen p53 inhibitor CHEMBL1401545 family 1 25
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 3 14
Cellular tumor antigen p53 and Prelamin-A/C inhibitor CHEMBL14... 2 11
Dual specificity tyrosine-phosphorylation-regulated kinase 1A ... 3 20
D(3) dopamine receptor and D(2) dopamine receptor ligand 2-[4-... 2 3
D(3) dopamine receptor and D(2) dopamine receptor ligand SureC... 5 4
Thyroid hormone receptor beta and Cruzipain ligand CHEMBL14730... 1 12
Adenosine receptor A2a and Adenosine receptor A1 ligand AGN-PC... 2 1
Dihydrofolate reductase inhibitor AC1LA5HU family 8 4
Bifunctional dihydrofolate reductase-thymidylate synthase and ... 6 13
Cellular tumor antigen p53 and Lysosomal alpha-glucosidase inh... 1 6
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 5 2
Inositol monophosphatase 1 inhibitor CHEMBL1588383 family 1 6
Melanocortin receptor 4 ligand AGN-PC-076AML family 3 24
D(4) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 3 6
Tyrosine-protein kinase JAK2 inhibitor AGN-PC-09QJGR family 3 13
Neuropeptide Y receptor type 5 ligand 3-[2-[6-[2-[(2-methylpro... 1 0
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor SureCN6... 2 4
Prostaglandin D2 receptor ligand 2-[3-[2-methoxy-6-[2-(4-metho... 4 12
Prostaglandin D2 receptor ligand 2-methoxy-N-[2-(4-methoxyphen... 2 5
Prostaglandin D2 receptor ligand 1-[3-[2-methoxy-6-[2-(4-metho... 6 16
Prostaglandin D2 receptor ligand 2-methoxy-N-[2-(4-methoxyphen... 2 2
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand AGN-P... 2 2
Metabotropic glutamate receptor 5 ligand AGN-PC-09QLD2 family 1 2
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 1 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 2 2
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-2-[[2-(die... 4 40
Integrin beta-1 and Integrin alpha-4 inhibitor SureCN2059024 f... 6 3
Insulin-like growth factor 1 receptor ligand 3qqu family 2 12
Platelet-activating factor receptor ligand SureCN7497229 family 4 2
Cannabinoid receptor 1 ligand AGN-PC-03I5TW family 3 12
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 5 4
Melanin-concentrating hormone receptor 1 ligand SureCN3334861 ... 1 3
Cholecystokinin receptor type A ligand AGN-PC-0A9ULH family 8 8
Serine/threonine-protein kinase PLK1 inhibitor AGN-PC-0A9RFQ f... 2 1
MAP kinase-activated protein kinase 2 inhibitor AGN-PC-09ODY0 ... 2 5
MAP kinase-activated protein kinase 2 inhibitor AGN-PC-0A9RSG ... 6 5
Calmodulin-domain protein kinase 1 and Tyrosine-protein kinase... 5 5
Integrin alpha-V and Integrin beta-5 inhibitor SureCN2491273 f... 11 10
Melatonin receptor type 1B ligand CHEMBL1802020 family 2 7
Cyclin-dependent kinase 4 and G1/S-specific cyclin-D1 inhibito... 9 10
Insulin receptor and Insulin-like growth factor 1 receptor lig... 17 7
Insulin-like growth factor 1 receptor and Potassium voltage-ga... 2 2
Tyrosine-protein kinase JAK2 inhibitor (2S)-1-[4-[4-[[7-(2-met... 11 27
Hepatocyte growth factor receptor ligand 4-[(6-phenyl-[1,2,4]t... 3 6
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 3 7
Acyl-CoA desaturase 1 and Acyl-CoA desaturase inhibitor 2-[4-[... 2 6
Corticotropin-releasing factor receptor 1 ligand N-(dicyclopro... 5 1
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 7 2
Mitogen-activated protein kinase 14 inhibitor 3-fluoro-N-[4-me... 2 5
Corticotropin-releasing factor receptor 1 ligand AGN-PC-009TSL... 3 3
Histamine H1 receptor and Histamine H4 receptor ligand 1H-benz... 2 7
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 6 0
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 8 1
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 5 0
cGMP-specific 3',5'-cyclic phosphodiesterase and Rod cGMP-spec... 24 5
Tyrosine-protein kinase BTK and Tyrosine-protein kinase Lyn in... 5 7
Tyrosine-protein kinase BTK and Tyrosine-protein kinase Lyn in... 3 0
Receptor tyrosine-protein kinase erbB-2 ligand N-[3-chloro-4-(... 4 3
Serine/threonine-protein kinase RIO2 and Serine/threonine-prot... 12 13
cGMP-dependent 3',5'-cyclic phosphodiesterase and cAMP and cAM... 3 10
Tyrosine-protein kinase JAK2 and Focal adhesion kinase 1 inhib... 3 1
MAP kinase-activated protein kinase 2 inhibitor N-[4-(4-oxospi... 3 0
Cathepsin S and Cathepsin L1 inhibitor arylaminoethyl amide, 1... 1 0
Corticotropin-releasing factor receptor 1 and Corticotropin-re... 2 1
Hepatocyte growth factor receptor and Cytochrome P450 3A4 liga... 5 2
Interleukin-1 receptor-associated kinase 4 and Interleukin-1 r... 4 0
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 4 4
Macrophage colony-stimulating factor 1 receptor and Ephrin typ... 1 0
Mitogen-activated protein kinase 14 inhibitor AGN-PC-075YQ1 fa... 4 0
Rho-associated protein kinase 1 and cAMP-dependent protein kin... 1 11
Serine/threonine-protein kinase B-raf and RAF proto-oncogene s... 1 0
Histamine H3 receptor ligand AGN-PC-075YXY family 1 4
Serine/threonine-protein kinase TBK1 and Inhibitor of nuclear ... 8 6
Serine/threonine-protein kinase TBK1 and Inhibitor of nuclear ... 2 8
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 3 6
Glycogen synthase kinase-3 beta inhibitor 2-(4-fluorophenyl)-N... 7 3
Smoothened homolog and Mitogen-activated protein kinase 14 inh... 3 0
Smoothened homolog and Mitogen-activated protein kinase 14 inh... 7 11
Epidermal growth factor receptor ligand SureCN4454332 family 18 5
Lysine--tRNA ligase inhibitor 4-[[[2-(2-piperazin-1-ylpyridin-... 2 1
cGMP-dependent 3',5'-cyclic phosphodiesterase and cAMP and cAM... 3 0
Platelet-derived growth factor receptor alpha and Vascular end... 3 1
Activated CDC42 kinase 1 inhibitor 5-(2-fluorophenyl)-N-[[(2S)... 5 0
D(4) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 2 2
Vasopressin V1a receptor and Vasopressin V2 receptor ligand 1-... 8 6
Substance-P receptor ligand (3S)-3-[2-methoxy-5-[5-(trifluorom... 4 5
Growth hormone secretagogue receptor type 1 ligand SureCN36800... 14 42
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 1 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 2 2
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 4 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 4 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 3 0
Rho-associated protein kinase 1 inhibitor SureCN4007647 family 8 4
Eukaryotic translation initiation factor 2-alpha kinase 3 inhi... 1 1
ALK tyrosine kinase receptor ligand 4-fluoro-N-[1-[4-(propan-2... 1 0
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 2 0
Cathepsin K and Cathepsin S inhibitor 2-Cyano-pyrimidine, 17i ... 3 6
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 2 1
Angiopoietin-1 receptor and Vascular endothelial growth factor... 4 8
Nitric oxide synthase, inducible inhibitor SureCN5194847 family 24 48
Nitric oxide synthase, inducible inhibitor 2-[1-(2-imidazol-1-... 4 3
Fatty-acid amide hydrolase 1 inhibitor 4-[[3-(4-chlorophenoxy)... 4 2
Glycogen synthase kinase-3 beta and Casein kinase I isoform ga... 3 0
Angiopoietin-1 receptor and Vascular endothelial growth factor... 4 6
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 3 2
Nitric oxide synthase, inducible inhibitor N-(1,3-benzodioxol-... 11 1
Tyrosine-protein kinase Lck inhibitor 3-[[2-(benzimidazol-1-yl... 2 0
Vascular endothelial growth factor receptor 2 and Serine/threo... 6 13
CGMP-dependent protein kinase inhibitor 1-[2-(4-fluorophenyl)-... 1 4
Corticotropin-releasing factor receptor 1 and Corticotropin-re... 3 14
Receptor tyrosine-protein kinase erbB-2 ligand SureCN4461871 f... 2 2
Vascular endothelial growth factor receptor 2 ligand 2-aminobe... 3 5
Receptor tyrosine-protein kinase erbB-2 ligand SureCN4463897 f... 3 2
Neuropeptide Y receptor type 5 ligand 6-ethylsulfonyl-2-(4-phe... 4 4
Mast/stem cell growth factor receptor Kit and Epithelial disco... 3 0
Adenosine receptor A2a and Cytochrome P450 3A4 ligand N-[6-(3,... 5 2
G-protein coupled bile acid receptor 1 ligand 2-ethyl-6-[3-[4-... 4 6
Aromatase inhibitor 2-(imidazol-1-ylmethyl)-6-methoxy-1-phenyl... 2 8
Motilin receptor ligand SureCN2765637 family 1 1
Tyrosine-protein kinase ABL1 and Breakpoint cluster region pro... 8 5
Histone-arginine methyltransferase CARM1 inhibitor AGN-PC-00HE... 4 4
cGMP-dependent 3',5'-cyclic phosphodiesterase inhibitor SureCN... 4 0
Renin and Cytochrome P450 3A4 inhibitor AGN-PC-046RG9 family 8 28
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-2-[[2-(die... 12 2
Diacylglycerol O-acyltransferase 1 inhibitor 4-[5-[5-(1H-benzi... 7 1
Tyrosine-protein kinase JAK2 inhibitor (2R)-2-[4-[[8-(4-methox... 2 0
Orexin receptor type 2 and Orexin receptor type 1 ligand 9-(4,... 2 5
Vascular endothelial growth factor receptor 2 and Angiopoietin... 3 3
Histamine H3 receptor and Sodium-dependent serotonin transport... 2 0
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor 8-[(6,7... 6 8
Angiopoietin-1 receptor and Vascular endothelial growth factor... 5 0
Adenosine receptor A2a ligand 8-(3-fluorophenyl)-3-[2-[4-[4-(2... 5 0
Collagenase 3 inhibitor 1-[6-[4-(1H-benzimidazol-2-yl)phenoxy]... 3 0
Cathepsin K and Cathepsin S inhibitor SureCN4135077 family 2 0
Melanin-concentrating hormone receptor 1 ligand (1S,3S)-3-N-(7... 2 2
Corticotropin-releasing factor receptor 1 and Corticotropin-re... 6 2
Hepatocyte growth factor receptor ligand AGN-PC-00AG7Q family 1 10
C-X-C chemokine receptor type 3 ligand N-[(1R)-1-[1-(4-ethoxyp... 5 9
Tyrosine-protein kinase Lck and Proto-oncogene tyrosine-protei... 4 3
Mitogen-activated protein kinase 14 inhibitor SureCN4913214 fa... 1 2
Leukotriene A-4 hydrolase inhibitor AGN-PC-00EW8S family 1 2
Histamine H1 receptor ligand N-[6-[2-[(4-methoxyphenyl)methyl-... 2 1
Dihydrofolate reductase inhibitor AC1LAPW3 family 3 0
Dihydrofolate reductase inhibitor AGN-PC-001U7R family 3 0
Substance-P receptor ligand N-[(2R)-1-[acetyl-[(2-chlorophenyl... 2 2
Gonadotropin-releasing hormone receptor ligand 2-tert-butyl-8-... 6 23
Vascular endothelial growth factor receptor 2 and Vascular end... 1 1
Insulin-like growth factor 1 receptor ligand 3-[8-amino-1-(4-e... 9 0
Tyrosine-protein kinase Lck and Vascular endothelial growth fa... 1 0
Vasopressin V1a receptor and Vasopressin V2 receptor ligand AG... 2 2
cGMP-inhibited 3',5'-cyclic phosphodiesterase B and cGMP-inhib... 16 0
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 6 0
D(3) dopamine receptor and D(2) dopamine receptor ligand SureC... 4 1
Glucagon receptor ligand SureCN2647807 family 3 7
Cyclin-dependent kinase 1 inhibitor AGN-PC-075VQQ family 2 0
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 3 1
Transient receptor potential cation channel subfamily V member... 18 1
Calcitonin gene-related peptide type 1 receptor ligand SureCN1... 1 3
Adenosine receptor A3 and Adenosine receptor A1 ligand N-[2-(4... 3 2
Cannabinoid receptor 2 ligand AGN-PC-03LKW5 family 24 5
RAF proto-oncogene serine/threonine-protein kinase inhibitor a... 8 6
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-3-[4-(2,6-... 3 1
Insulin-like growth factor 1 receptor ligand SureCN311483 family 3 0
Coagulation factor X inhibitor SureCN5641901 family 5 0
Cholecystokinin receptor type A ligand AGN-PC-077L8J family 22 2
Rho-associated protein kinase 2 inhibitor SureCN1519463 family 5 1
Hepatocyte growth factor receptor ligand 4-pyridone analogue, ... 8 0
Rho-associated protein kinase 2 inhibitor AGN-PC-078WHL family 3 1
Peroxisome proliferator-activated receptor gamma ligand (2S)-2... 8 0
Adenosine receptor A2a and Adenosine receptor A1 ligand AGN-PC... 7 5
Insulin-like growth factor 1 receptor ligand AGN-PC-050GPS family 7 0
Cathepsin S and Cathepsin K inhibitor 2-cyano-pyrropyrimidine,... 4 1
Oxytocin receptor and Vasopressin V1a receptor ligand AGN-PC-0... 4 3
Adenosine receptor A2a ligand AGN-PC-077RYH family 16 5
Translocator protein inhibitor AGN-PC-04X3HY family 10 1
5-hydroxytryptamine receptor 2B ligand SureCN1299002 family 2 8
Cholecystokinin receptor type A ligand SureCN3132309 family 11 0
Adenosine receptor A3 and Adenosine receptor A1 ligand CHEMBL4... 2 3
Tyrosine-protein kinase SYK and Tyrosine-protein kinase ZAP-70... 3 8
Nociceptin receptor and Delta-type opioid receptor ligand 2-[3... 2 1
Cathepsin S and Cathepsin K inhibitor AGN-PC-078ZDC family 4 2
Tyrosine-protein kinase ITK/TSK inhibitor AGN-PC-077RCV family 2 1
Adenosine receptor A2a and Adenosine receptor A1 ligand SureCN... 3 5
P2X purinoceptor 7 inhibitor N-[2,2-dichloro-1-[(Z)-[(cyanoami... 1 2
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor AGN-PC-... 3 1
Hepatocyte growth factor receptor and Cytochrome P450 3A4 liga... 5 0
Hepatocyte growth factor receptor ligand AGN-PC-077PZW family 1 0
Epidermal growth factor receptor ligand Pyrido[3,4-d]pyrimidin... 3 1
Acyl-CoA desaturase inhibitor SureCN1182546 family 2 5
Acyl-CoA desaturase inhibitor SureCN1182719 family 1 0
D(2) dopamine receptor ligand AGN-PC-07C1V6 family 2 3
Insulin-like growth factor 1 receptor ligand AGN-PC-07C5TC family 2 4
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor AGN-PC-... 7 6
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 2 0
Delta-type opioid receptor and Kappa-type opioid receptor liga... 3 1
LIM domain kinase 2 and LIM domain kinase 1 inhibitor SureCN36... 1 1
Histone-arginine methyltransferase CARM1 inhibitor AGN-PC-07CR... 4 0
Tyrosine-protein kinase Lck inhibitor AGN-PC-07R5ZB family 4 3
Matrilysin and 72 kDa type IV collagenase inhibitor (3S,6R,7S)... 2 2
Macrophage colony-stimulating factor 1 receptor ligand SureCN1... 1 0
Mitogen-activated protein kinase 14 inhibitor AGN-PC-09M5I2 fa... 1 3
Cyclin-dependent kinase 2 and Cyclin-dependent kinase 4 inhibi... 3 7
Sphingosine 1-phosphate receptor 1 ligand (2S)-2-[[2-(1H-imida... 4 7
Bifunctional epoxide hydrolase 2 and Arachidonate 5-lipoxygena... 3 0
Metabotropic glutamate receptor 5 ligand 2-[4-(4-fluoro-3-meth... 1 0
Protein kinase C theta type inhibitor SureCN3953579 family 2 1
Beta-2 adrenergic receptor and Beta-3 adrenergic receptor liga... 4 6
Tryptophan 5-hydroxylase 1 inhibitor (2S)-2-amino-3-[4-[5-[(3,... 1 3


CFAM Mol ID

External ID

Functional Category

Molecule Name


Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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