CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM45092
Family Name Cytochrome P450 3A4 inhibitor N-[2-fluoro-4-(4-fluorophenyl)phenyl]-N-(pyridin-3-ylmethyl)methanesulfonamide family
No. of Seeds 2 No. of Other Members 1
Family Centroid CFAMM00525349 Functional Category Bioactive
Superfamily Cytochrome P450 2C9 and Cytochrome P450 3A4 Binder Superfamily 5
Class Class 433

Cousin Family NamesSeedsMembers
5-hydroxytryptamine receptor 1B ligand triptan Almotriptan Family 8 438
Nicotinic acetylcholine receptor Ligand Nicotine Family 14 686
Histamine H1 receptor ligand tricyclic antidepressant Deslorat... 6 136
Prostaglandin G/H synthase 2 Inhibitor Etoricoxib Family 2 99
Solute carrier family 12 member 1 Inhibitor Torasemide Family 13 75
Histamine H1 receptor Ligand Pheniramine Family 10 380
Histamine H1 receptor Ligand Triprolidine Family 19 316
Enoyl-[acyl-carrier-protein] reductase [NADH] Inhibitor Ethion... 5 68
5-hydroxytryptamine receptor 6 Ligand SB-742457 Family 9 66
Cytochrome P450 11B1, mitochondrial and Aromatase Inhibitor 3-... 2 11
Cytochrome P450 11B1, mitochondrial and Aromatase Inhibitor 3-... 14 22
5-hydroxytryptamine receptor 6 Ligand 4-(1h-indol-1-ylsulfonyl... 7 79
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 3 2
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 13 26
Inosine-5'-monophosphate dehydrogenase 2 Inhibitor 1-methyl-1h... 6 24
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 14 19
NF-kappa-B Inhibitor 2-nitro-n-(quinolin-8-yl)benzenesulfonami... 2 3
Carbonic anhydrase 2 and Carbonic anhydrase 9 Inhibitor Quinol... 4 13
5-hydroxytryptamine receptor 6 Ligand 6-tosyl-1,2,3,4,5,6-hexa... 4 22
Acetylcholinesterase and Cholinesterase Inhibitor 1,9-bis(pyri... 8 38
Prostaglandin G/H synthase 1 Inhibitor 1-(4-aminosulfonylpheny... 3 18
Steroid 17-alpha-hydroxylase/17,20 lyase and Cytochrome P450 1... 2 4
Ribosyldihydronicotinamide dehydrogenase [quinone] Inhibitor N... 6 10
Cytochrome P450 11B1, mitochondrial Inhibitor 2-methyl-1,2-di-... 8 15
Metabotropic glutamate receptor 5 Ligand 3-m-tolyl-1,5-naphthy... 6 10
Metabotropic glutamate receptor 5 Ligand 5-((6-methylpyridin-2... 14 22
Choline kinase alpha Inhibitor Bisquinolinium Derivative Family 10 7
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor (2R)-... 5 10
Prelamin-A/C and Survival motor neuron protein inhibitor CHEMB... 1 0
Carbonic anhydrase 9 and Carbonic anhydrase 2 inhibitor 4-[2-(... 2 6
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor 1,1,1... 12 3
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor [1-[4... 2 0
Kinesin-like protein KIF11 inhibitor AGN-PC-077SFB family 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00525351 CHEMBL320151 Bioactive AGN-PC-044KFP
CFAMM00525349 CHEMBL2448741 Bioactive N-[2-fluoro-4-(4-fluorophenyl)phenyl]-N-(pyridin-3-ylmethyl)methanesulfonamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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