CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM45205
Family Name Beta-secretase 1 and Cathepsin D inhibitor 2-[2-(1-adamantyl)-5-phenylpyrrol-1-yl]-N-[N'-(2-hydroxyethyl)carbamimidoyl]acetamide family
No. of Seeds 11 No. of Other Members 0
Family Centroid CFAMM00525569 Functional Category Bioactive
Superfamily Cathepsin D and Beta-secretase 1 Binder Superfamily 13
Class Class 147

Cousin Family NamesSeedsMembers
Kappa-type opioid receptor and Mu-type opioid receptor Ligand ... 19 108
Dipeptidyl peptidase 4 inhibitor AGN-PC-09QKOM family 5 8


External ID

Functional Category

Molecule Name

CFAMM00525569 CHEMBL258355 Bioactive 2-[2-(1-adamantyl)-5-phenylpyrrol-1-yl]-N-[N'-(2-hydroxyethyl)carbamimidoyl]acetamide
CFAMM00525562 CHEMBL403819 Bioactive Acylguanidine, 10b
CFAMM00525568 CHEMBL404897 Bioactive 2-[2-(1-adamantyl)-5-phenylpyrrol-1-yl]-N-[N'-(4-hydroxybutyl)carbamimidoyl]acetamide
CFAMM00525561 CHEMBL256063 Bioactive 2-[2-(1-adamantyl)-5-phenylpyrrol-1-yl]-N-[N'-[(2R)-2-hydroxypropyl]carbamimidoyl]acetamide
CFAMM00525567 CHEMBL258356 Bioactive 2-[2-(1-adamantyl)-5-phenylpyrrol-1-yl]-N-[N'-(2-cyanoethyl)carbamimidoyl]acetamide
CFAMM00525560 CHEMBL402330 Bioactive Acylguanidine, 7b
CFAMM00525566 CHEMBL257099 Bioactive 2-[2-(1-adamantyl)-5-phenylpyrrol-1-yl]-N-[N'-[(3-aminophenyl)methyl]carbamimidoyl]acetamide
CFAMM00525559 CHEMBL401832 Bioactive 2-[2-(1-adamantyl)-5-phenylpyrrol-1-yl]-N-[N'-(2,3-dihydroxypropyl)carbamimidoyl]acetamide
CFAMM00525565 CHEMBL402576 Bioactive 2-[2-(1-adamantyl)-5-phenylpyrrol-1-yl]-N-[N'-(4-hydroxycyclohexyl)carbamimidoyl]acetamide
CFAMM00525564 CHEMBL438355 Bioactive 2-[2-(1-adamantyl)-5-phenylpyrrol-1-yl]-N-[N'-(3-cyanopropyl)carbamimidoyl]acetamide
CFAMM00525563 CHEMBL258315 Bioactive 2-[2-(1-adamantyl)-5-phenylpyrrol-1-yl]-N-[N'-[(2S)-2-hydroxypropyl]carbamimidoyl]acetamide

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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Computer-aided Drug Design
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