CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM4547
Family Name Prothrombin and Trypsin-1 inhibitor SureCN12636557 family
No. of Seeds 9 No. of Other Members 1
Family Centroid CFAMM00357297 Functional Category Bioactive
Superfamily Prothrombin and Trypsin-1 Binder Superfamily
Class Class 1006

Cousin Family NamesSeedsMembers
Histamine H1 receptor Ligand Triprolidine Family 19 316
Transient receptor potential cation channel subfamily V member... 16 295
Transient receptor potential cation channel subfamily V member... 6 66
Gamma-aminobutyric acid receptor Ligand E-2007 Family 7 118
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 14 234
Aurora kinase B and Aurora kinase A Inhibitor PF-03814735 Family 2 12
Histone deacetylase 6 Inhibitor ACY-1215 Family 10 230
C-C chemokine receptor type 3 Ligand YM-344031 Family 19 106
cGMP-dependent 3',5'-cyclic phosphodiesterase Inhibitor CP-461... 4 34
Beta-secretase 1 Inhibitor N~3~-(3-pyridin-3-ylbenzyl)pyridine... 31 66
Serine/threonine-protein kinase B-raf Inhibitor 2-(benzylamino... 7 117
Epidermal growth factor receptor Ligand PD-158780 Family 98 89
D(2) dopamine receptor and D(3) dopamine receptor Ligand A-706... 4 20
Delta-type opioid receptor Ligand H-poa-ser-gly-phe-leu-thr-oh... 5 12
Transient receptor potential cation channel subfamily V member... 2 26
Metabotropic glutamate receptor 5 Ligand 5-((6-methylpyridin-2... 14 22
Prothrombin inhibitor SureCN5855286 family 15 8
Prothrombin inhibitor SureCN7371121 family 13 3
Prothrombin inhibitor SureCN5854779 family 4 9
Prothrombin inhibitor 2-[6-chloro-3-[(2,2-difluoro-2-pyridin-2... 5 0
Prothrombin inhibitor SureCN5856722 family 3 16
Corticotropin-releasing factor receptor 1 ligand 5-chloro-1-[(... 1 2
5-hydroxytryptamine receptor 1A and D(1A) dopamine receptor li... 2 3
Prothrombin inhibitor (2S)-N-[(6-carbamimidoylpyridin-3-yl)met... 2 14
Cathepsin K and Potassium voltage-gated channel subfamily H me... 5 1
Cathepsin K inhibitor SureCN2155973 family 3 1
Mitogen-activated protein kinase 1 and Cytochrome P450 3A4 inh... 1 0
Platelet-activating factor receptor ligand YM-461 family 1 11
Prothrombin and Trypsin-1 inhibitor 2-[6-methyl-2-oxo-3-(2-pyr... 4 2
Prothrombin inhibitor AGN-PC-09QKE4 family 1 0
Neuropeptide Y receptor type 5 ligand (5E)-5-[(4S,5S)-4-(4-flu... 18 3
Toll-like receptor 7 ligand 4-amino-1-[[6-[(2S)-2-(pyrrolidin-... 4 0
Beta-secretase 1 and Beta-secretase 2 inhibitor 5-[(1R)-3-amin... 8 1
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 8 inhibitor Di... 2 3
Renin inhibitor (E)-but-2-enedioic acid;(3S,5R)-5-[4-(2-chloro... 6 8
Dipeptidyl peptidase 4 and Cytochrome P450 2D6 inhibitor (3R)-... 4 12
Bifunctional epoxide hydrolase 2 and Cytochrome P450 2C9 inhib... 3 0
Histamine H3 receptor ligand [1-[(2-aminopyridin-4-yl)methyl]-... 2 0
C-X-C chemokine receptor type 3 ligand 1-[3-[[(1R,5S)-3-[[7-(t... 3 1
Prothrombin inhibitor 2-[4-methyl-5-[[[2-[6-methyl-2-oxo-3-(2-... 1 0
Prothrombin inhibitor AGN-PC-073GVF family 12 1
Platelet-activating factor receptor ligand SureCN9853140 family 3 3
Neuropeptide Y receptor type 5 ligand SureCN4464548 family 17 2
Beta-secretase 1 and Beta-secretase 2 inhibitor SureCN4964150 ... 3 0
Transient receptor potential cation channel subfamily V member... 3 2
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor AGN-PC-... 4 2
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor SureCN8... 3 0
Glycogen synthase kinase-3 beta inhibitor SureCN13987027 family 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00357293 CHEMBL29657 Bioactive SureCN7719594
CFAMM00357299 CHEMBL142370 Bioactive 2-[6-chloro-3-[(2,2-difluoro-2-pyridin-2-ylethyl)amino]-2-oxopyrazin-1-yl]-N-[(4-methylpyridin-2-yl)methyl]acetamide
CFAMM00357302 CHEMBL142240 Bioactive AGN-PC-00FNEW
CFAMM00357297 CHEMBL30054 Bioactive SureCN12636557
CFAMM00357296 CHEMBL143024 Bioactive 2-[6-cyano-3-[(2,2-difluoro-2-pyridin-2-ylethyl)amino]-2-oxopyrazin-1-yl]-N-[(3-fluoropyridin-2-yl)methyl]acetamide
CFAMM00357295 CHEMBL29019 Bioactive SureCN7369853
CFAMM00357301 CHEMBL422299 Bioactive 2-[6-cyano-3-[(2,2-difluoro-2-pyridin-2-ylethyl)amino]-2-oxopyrazin-1-yl]-N-[(3-fluoro-4-methylpyridin-2-yl)methyl]acetamide
CFAMM00357294 CHEMBL141889 Bioactive 2-(6-CHLORO-3-{[2,2-DIFLUORO-2-(2-PYRIDINYL)ETHYL]AMINO}-2-OXO-1(2H)-PYRAZINYL)-N-[(2-FLUORO-6-PYRIDINYL)METHYL]ACETAMIDE
CFAMM00357300 CHEMBL142776 Bioactive 2-[6-chloro-3-[(2,2-difluoro-2-pyridin-2-ylethyl)amino]-2-oxopyrazin-1-yl]-N-[(3-chloropyridin-2-yl)methyl]acetamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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