CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM455
Family Name Dipeptidyl peptidase 1 inhibitor (2S)-2-amino-N-[(1S)-1-cyano-2-(1H-indol-3-yl)ethyl]-3-thiophen-2-ylpropanamide family
No. of Seeds 2 No. of Other Members 14
Family Centroid CFAMM00311704 Functional Category Bioactive with Natural Product
Superfamily Dipeptidyl peptidase 1 and Tyrosine-protein kinase JAK3 Binder Superfamily
Class Class 2305

Cousin Family NamesSeedsMembers
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 14 2769
D(1A) dopamine receptor ligand ergot alkaloid Methylergonovine... 22 170
Gastrin/cholecystokinin type B receptor ligand peptide Pentaga... 26 1171
Somatostatin receptor type 2 ligand octapeptide Octreotide Family 27 172
Indoleamine 2,3-dioxygenase 1 Inhibitor L-tryptophan Family 8 328
Hepatocyte growth factor receptor Ligand Arq 197 Family 10 400
Substance-P receptor Ligand GSK424887 Family 8 184
Growth hormone receptor Ligand EP-51216 Family 34 390
Lethal factor Inhibitor GM6001 Family 50 435
Somatostatin receptor type 2 Ligand L-054852 Family 13 88
Carbonic anhydrase 2 Inhibitor N-[2-(1h-indol-5-yl)-butyl]-4-s... 12 70
Poly [ADP-ribose] polymerase 1 Inhibitor 1,7,8,9-tetrahydro-1,... 19 64
Melanocortin receptor 3 and Melanocortin receptor 4 Ligand C[n... 12 10
Inosine-5'-monophosphate dehydrogenase 2 Inhibitor 3-(thiophen... 9 66
Melanocortin receptor 3 and Melanocortin receptor 4 Ligand C[c... 20 18
5-hydroxytryptamine receptor 2C Ligand Cyclo[(6-bromotryptopha... 3 17
Cytochrome P450 11B1, mitochondrial and Aromatase Inhibitor 5-... 4 10
Sodium-dependent serotonin transporter Inhibitor 3-(3-aminocyc... 94 23
Endothelin B receptor Ligand IRL-2500 Family 34 87
Vasopressin V1a receptor and Vasopressin V1b receptor Ligand D... 10 19
Histone deacetylase Inhibitor ST-5732 Family 8 6
Bombesin receptor subtype-3 and Gastrin-releasing peptide rece... 42 7
Dipeptidyl peptidase 4 inhibitor (1S,3S,5S)-2-[(2S)-2-amino-2-... 3 5
Endothelin-converting enzyme 1 inhibitor 2-[[1-[[(2S)-4-methyl... 2 8
Deoxycytidine kinase inhibitor N-[(1S,3S)-3-(4-amino-5-fluoro-... 2 5
Neuropeptide S receptor and Prelamin-A/C ligand CHEMBL1367658 ... 1 7
Histone deacetylase 3 and Histone deacetylase 6 inhibitor Tria... 20 37
Growth hormone secretagogue receptor type 1 ligand 2-amino-N-[... 1 0
Nuclear receptor ROR-gamma and Niemann-Pick C1 protein ligand ... 1 12
5-hydroxytryptamine receptor 2A and D(2) dopamine receptor lig... 2 4
Disintegrin and metalloproteinase domain-containing protein 17... 4 0
Survival motor neuron protein and Menin inhibitor CHEMBL151109... 1 11
Coagulation factor X and Prothrombin inhibitor (2S)-2-(benzyls... 4 4
Serine/threonine-protein kinase D3 and Protein kinase C delta ... 3 10
Metabotropic glutamate receptor 1 ligand GTPL6334 family 6 4
Neuromedin-K receptor ligand 3-methylsulfinyl-N-[(1S)-1-phenyl... 3 5
Substance-P receptor ligand N-[(2S)-5-[3,5-bis(trifluoromethyl... 4 6
72 kDa type IV collagenase and Matrix metalloproteinase-9 inhi... 5 1
Neuropeptide Y receptor type 5 ligand 2-indol-1-yl-N-[4-[(prop... 7 6
Dipeptidyl peptidase 4 inhibitor [(2S,4S)-4-(4-quinolin-4-ylpi... 5 8
Cathepsin K and Cathepsin S inhibitor (2S)-N-(cyanomethyl)-4-m... 1 0
Histone deacetylase 1 inhibitor 5-[5-[[(2-chlorophenyl)methyla... 4 1
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 9 inhibitor (2... 5 5
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 8 inhibitor (2... 2 0
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 8 inhibitor (2... 2 2
Metabotropic glutamate receptor 1 ligand 4-[1-(2-fluoropyridin... 1 0
Platelet-activating factor receptor ligand (1-ethylindol-3-yl)... 17 13
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 2 2
Neutrophil collagenase and Interstitial collagenase inhibitor ... 1 0
Epidermal growth factor receptor and Vascular endothelial grow... 14 19
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand SureC... 2 0
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor CHEMBL3... 1 9


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00311704 CHEMBL1081150 Bioactive (2S)-2-amino-N-[(1S)-1-cyano-2-(1H-indol-3-yl)ethyl]-3-thiophen-2-ylpropanamide
CFAMM00311717 CHEMBL2418639 Bioactive (2S)-1-[(2S)-2-amino-3-[4-[1-(thiophen-2-ylmethyl)triazol-4-yl]phenyl]propanoyl]pyrrolidine-2-carbonitrile;hydrochloride

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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