CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM4562
Family Name Gamma-aminobutyric acid receptor subunit pi and GABA theta subunit ligand BRN 4768157 family
No. of Seeds 4 No. of Other Members 4
Family Centroid CFAMM00131844 Functional Category Bioactive
Superfamily Corticotropin-releasing factor receptor 1 Ligand BMS-561388 Superfamily
Class Class 2074

Cousin Family NamesSeedsMembers
Histamine H1 receptor Ligand Astemizole Family 7 240
Corticotropin-releasing factor receptor 1 Ligand CRF-1 Antagon... 29 421
Insulin-like growth factor 1 receptor Ligand AEW-541 Family 12 140
Corticotropin-releasing factor receptor 1 Ligand GSK561679 Family 5 6
Corticotropin-releasing factor receptor 1 Ligand GW876008 Family 3 30
Hepatocyte growth factor receptor Ligand Amg 208 Family 20 236
Ibrutinib family 2 27
Peptide deformylase, mitochondrial Inhibitor Epiroprim Family 5 68
Tyrosine kinase Inhibitor PKI166 Family 17 198
Vascular endothelial growth factor receptor 2 Ligand L00002164... 6 23
Cyclin-dependent kinase 2 and Cyclin-dependent kinase 4 Inhibi... 19 48
Adenosine receptor A1 and Adenosine receptor A3 Ligand 2-(4-me... 3 23
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 12 37
Corticotropin-releasing factor receptor 1 Ligand BMS-561388 Fa... 10 16
Sodium channel protein type 5 subunit alpha Ligand Enecadin Fa... 1 11
cGMP-specific 3',5'-cyclic phosphodiesterase Inhibitor SK&F-96... 5 83
Serine/threonine-protein kinase B-raf inhibitor SureCN1015955 ... 17 18
Adenosine receptor A3 and Adenosine receptor A2a ligand AGN-PC... 3 4
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 6 11
Adenosine receptor A3 ligand AGN-PC-07N4XZ family 4 11
Adenosine receptor A3 ligand CHEMBL1834696 family 5 18
Corticotropin-releasing factor receptor 1 ligand AGN-PC-068CC4... 20 7
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 31 11
Proto-oncogene tyrosine-protein kinase Src and Phosphatidylino... 4 20
Tyrosine-protein kinase ABL1 and Tyrosine-protein kinase HCK i... 2 2
Translocator protein inhibitor AGN-PC-080ILF family 9 3
Hormone-sensitive lipase inhibitor N-methyl-5-methylsulfanyl-N... 3 8
DNA-(apurinic or apyrimidinic site) lyase and Ras-related prot... 1 5
Survival motor neuron protein and Huntingtin inhibitor 3,6-bis... 1 23
Cellular tumor antigen p53 inhibitor CHEMBL1401545 family 1 25
Cellular tumor antigen p53 and Microtubule-associated protein ... 1 6
Tyrosine-protein kinase JAK2 inhibitor 5-(3-methoxyphenyl)-N-[... 2 11
Prostaglandin D2 receptor ligand 2-methoxy-N-[2-(4-methoxyphen... 2 5
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 7 6
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 5 1
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor AGN-P... 8 17
Neuropeptide Y receptor type 1 ligand CP-671906 family 10 0
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 3 0
Calmodulin-domain protein kinase 1 and Tyrosine-protein kinase... 5 5
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 6 0
Corticotropin-releasing factor receptor 1 ligand AGN-PC-005GB4... 6 3
Corticotropin-releasing factor receptor 1 ligand CHEMBL1819076... 2 0
Hepatocyte growth factor receptor ligand 4-[(6-phenyl-[1,2,4]t... 3 6
Corticotropin-releasing factor receptor 1 ligand CHEMBL1830528... 1 0
Serine/threonine-protein kinase pim-1 and Serine/threonine-pro... 4 9
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 8 17
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 6 0
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 4 4
cGMP-dependent 3',5'-cyclic phosphodiesterase and cAMP and cAM... 3 0
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 25 2
Corticotropin-releasing factor receptor 1 and Corticotropin-re... 4 0
Vasopressin V1a receptor and Vasopressin V2 receptor ligand 1-... 8 6
Estrogen receptor and Estrogen receptor beta ligand 4-[3-[4-(2... 1 0
Histamine H3 receptor and Potassium voltage-gated channel subf... 1 0
cGMP-dependent 3',5'-cyclic phosphodiesterase inhibitor SureCN... 4 0
Tyrosine-protein kinase JAK2 inhibitor (2R)-2-[4-[[8-(4-methox... 2 0
Cathepsin K and Cathepsin S inhibitor SureCN4135077 family 2 0
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor SureC... 2 0
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor 4-[4-... 1 0
Bifunctional dihydrofolate reductase-thymidylate synthase inhi... 2 6
Type-1 angiotensin II receptor ligand 2-ethyl-6-methoxy-N-[[4-... 2 0
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 2 2
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 5 0
Activated CDC42 kinase 1 and Tyrosine-protein kinase Lck inhib... 4 0
Oxytocin receptor and Vasopressin V1a receptor ligand AGN-PC-0... 4 3
Adenosine receptor A2a ligand AGN-PC-077RYH family 16 5
Corticotropin-releasing factor receptor 1 ligand AGN-PC-068CCL... 3 0
Cathepsin S and Cathepsin K inhibitor AGN-PC-078ZDC family 4 2
Corticotropin-releasing factor receptor 1 ligand AGN-PC-068CCI... 3 0
Hepatocyte growth factor receptor ligand AGN-PC-077K0V family 3 0
Hepatocyte growth factor receptor ligand 4-[(6-thiophen-2-yl-[... 4 0
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 2 0
Aurora kinase A and Glycogen synthase kinase-3 beta inhibitor ... 1 2
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 2 0
Acyl-CoA desaturase 1 inhibitor Pyridazine, 3-[4-(2-ethylpheno... 4 2
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 2 0
Type-1 angiotensin II receptor ligand SureCN9402384 family 3 0
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 2 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00357434 CHEMBL14645 Bioactive BRN 6445482
CFAMM00357441 CHEMBL14202 Bioactive BRN 6437837
CFAMM00357440 CHEMBL269449 Bioactive BRN 6438104

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

48716 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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