CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM45898
Family Name Dihydrofolate reductase inhibitor 5-[[4-(dimethylamino)phenyl]methyl]-4,5-dihydropyrimidine-2,6-diamine family
No. of Seeds 1 No. of Other Members 0
Family Centroid CFAMM00527001 Functional Category Bioactive
Superfamily Histamine H1 receptor Ligand Antazoline Superfamily
Class Class 655

Cousin Family NamesSeedsMembers
5-hydroxytryptamine receptor 5A Ligand N,4-dimethyl-3,4-dihydr... 8 51
Glutamate receptor ionotropic, NMDA 2A and Glutamate receptor ... 14 78
5-hydroxytryptamine receptor 3A Ligand 1-(biphenyl-4-yl)-3-(4-... 20 67
ATP-binding cassette sub-family C member 9 and ATP-sensitive i... 1 2
Cytochrome P450 2C9 and Cytochrome P450 2D6 inhibitor N'-(4-he... 1 0


External ID

Functional Category

Molecule Name

CFAMM00527001 CHEMBL333022 Bioactive 5-[[4-(dimethylamino)phenyl]methyl]-4,5-dihydropyrimidine-2,6-diamine

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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