CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM4607
Family Name Dihydroorotate dehydrogenase (quinone), mitochondrial inhibitor 1-(4-chlorophenyl)-5-N-(4-piperidin-1-ylphenyl)-3-N-(pyridin-3-ylmethyl)pyrazole-3,5-dicarboxamide family
No. of Seeds 2 No. of Other Members 21
Family Centroid CFAMM00357708 Functional Category Bioactive
Superfamily Histidine decarboxylase Inhibitor Bf-derm1 Superfamily
Class Class 849

Cousin Family NamesSeedsMembers
5-hydroxytryptamine receptor 3A Ligand Granisetron Family 26 212
Cannabinoid receptor 1 Ligand Rimonabant Family 20 260
Histidine decarboxylase Inhibitor Bf-derm1 Family 12 95
Glycogen phosphorylase, muscle form Inhibitor PSN357 Family 3 253
Reverse transcriptase Inhibitor IDX899 Family 2 118
Poly [ADP-ribose] polymerase 1 Inhibitor MK-4827 Family 8 43
Cannabinoid receptor 1 Ligand TM38837 Family 20 15
TGF-beta receptor type-1 Ligand LY2157299 Family 13 56
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 4 93
Adenosine receptor A3 Ligand 2-benzyl-2h-pyrazolo[3,4-c]quinol... 3 11
14-alpha sterol demethylase Inhibitor CP-320626 Family 13 76
Sodium channel protein type 10 subunit alpha Ligand N-benzyl-5... 11 46
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 5 22
Vasopressin V2 receptor Ligand YM-35278 Family 33 38
RAC-alpha serine/threonine-protein kinase and Cyclin-dependent... 3 7
Dihydroorotate dehydrogenase (quinone), mitochondrial inhibito... 3 59
Vasopressin V1b receptor ligand 2-[3-(3-chlorophenyl)-1-oxo-7-... 2 12
Mitogen-activated protein kinase 14 inhibitor AGN-PC-09M8RE fa... 6 1
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand AGN-P... 8 16
Bifunctional epoxide hydrolase 2 inhibitor AGN-PC-09M6D1 family 2 5
Acetylcholinesterase inhibitor CHEMBL1651131 family 6 9
Ceramide glucosyltransferase inhibitor AGN-PC-07YS0C family 4 3
Glucocorticoid receptor ligand N-ethyl-2-fluoro-N-[3,3,3-trifl... 16 7
Inhibitor of nuclear factor kappa-B kinase subunit beta inhibi... 34 4
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 8 inhibitor 2-... 18 2
Substance-P receptor and Neuromedin-K receptor ligand SureCN88... 4 14
Cyclin-A2 and Cyclin-dependent kinase 2 inhibitor dihydro-benz... 3 5
Cannabinoid receptor 1 ligand N-[1-[[(1R)-1-[4-(3-chloroindazo... 10 0
Cannabinoid receptor 1 ligand 5-(4-chlorophenyl)-1-(2,4-dichlo... 2 19
Histone deacetylase 1 inhibitor (E)-N-hydroxy-3-[4-[[2-(2-meth... 7 9
Coagulation factor X and Prothrombin inhibitor 2-carboxyindole... 2 8
Coagulation factor X inhibitor AGN-PC-0749BY family 5 9
Dipeptidyl peptidase 9 and Dipeptidyl peptidase 8 inhibitor 3-... 3 6
Ribosomal protein S6 kinase alpha-3 inhibitor 1-oxo-N-[1-(pyri... 5 11
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 5 4
Lysosomal Pro-X carboxypeptidase inhibitor [(3S,4R)-1-tert-but... 20 13
Coagulation factor X inhibitor 2-(6-chloronaphthalen-2-yl)-5-m... 2 0
Coagulation factor X inhibitor SureCN8169809 family 12 18
Coagulation factor X inhibitor SureCN8165148 family 4 0
Coagulation factor X inhibitor AGN-PC-0749DA family 3 2
Coagulation factor X inhibitor AGN-PC-02WFR7 family 7 13
Mitogen-activated protein kinase 1 inhibitor Pyrrole Carboxami... 3 12
Coagulation factor X and Prothrombin inhibitor SureCN5819494 f... 5 8
Dual specificity protein kinase CLK4 and Mitogen-activated pro... 1 1
Coagulation factor X inhibitor 3-chloro-N-[(1S,2S)-2-[[4-(2-ox... 22 3
Metabotropic glutamate receptor 5 ligand 5-(4-fluorophenyl)-1,... 7 1
Metabotropic glutamate receptor 5 ligand 5-(4-chlorophenyl)-1,... 3 1
Coagulation factor X inhibitor ethyl (3R,4S)-3-[(3-chloro-1H-i... 5 0
Serine/threonine-protein kinase PLK4 inhibitor (3E)-3-[[3-[(E)... 5 2
Acetyl-CoA carboxylase 2 and Acetyl-CoA carboxylase 1 inhibito... 4 1
Acetyl-CoA carboxylase 2 and Acetyl-CoA carboxylase 1 inhibito... 3 0
Cannabinoid receptor 1 ligand AGN-PC-07R6QU family 4 2
Neuromedin-B receptor and Gastrin-releasing peptide receptor l... 2 0
D(4) dopamine receptor and D(1A) dopamine receptor ligand 3-[[... 1 0
Cannabinoid receptor 1 ligand AGN-PC-07NHJ5 family 9 1
Vasopressin V2 receptor and Vasopressin V1a receptor ligand (2... 1 0
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 2 1
Cannabinoid receptor 1 ligand AGN-PC-07R5TU family 11 0
Cannabinoid receptor 1 ligand AGN-PC-07NHI2 family 4 1
Poly [ADP-ribose] polymerase 1 inhibitor SureCN3553433 family 22 0
Cannabinoid receptor 1 ligand AGN-PC-07R6O8 family 5 2
Cannabinoid receptor 1 ligand AGN-PC-07RA6C family 21 2
Cannabinoid receptor 1 ligand AGN-PC-07RA3R family 15 0
Cannabinoid receptor 1 ligand AGN-PC-07R6QS family 5 0
Poly [ADP-ribose] polymerase 1 inhibitor AGN-PC-07R9GP family 5 0
Mitogen-activated protein kinase 10 and Mitogen-activated prot... 4 0
Cyclin-dependent kinase 2 inhibitor N-[(4-chlorophenyl)carbamo... 7 2


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00357708 CHEMBL142444 Bioactive 1-(4-chlorophenyl)-5-N-(4-piperidin-1-ylphenyl)-3-N-(pyridin-3-ylmethyl)pyrazole-3,5-dicarboxamide
CFAMM00357700 CHEMBL341925 Bioactive 1-(4-chlorophenyl)-5-N-phenyl-3-N-(pyridin-3-ylmethyl)pyrazole-3,5-dicarboxamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

45057 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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