CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM467
Family Name Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha and Protein farnesyltransferase subunit beta inhibitor (2S)-2-[[2-(2-methylphenyl)-4-[(E)-2-pyridin-3-ylethenyl]benzoyl]amino]-4-methylsulfanylbutanoic acid family
No. of Seeds 17 No. of Other Members 14
Family Centroid CFAMM00311842 Functional Category Bioactive with Natural Product
Superfamily Protein farnesyltransferase subunit beta and Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha Binder Superfamily
Class Class 137

Cousin Family NamesSeedsMembers
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 14 2769
HIV protease Inhibitor Saquinavir Family 64 428
Cytochrome P450 11B1, mitochondrial Inhibitor Metyrapone Family 9 243
Sodium channel protein type 5 subunit alpha Ligand Disopyramid... 4 352
SUR2-type K(ATP) channel Ligand Nicorandil Family 5 85
Prothrombin Inhibitor Ximelegatran Family 8 157
Farnesyltransferase beta subunit, putative Inhibitor AZD3409 F... 2 2
Neuromedin-K receptor Ligand SB222200 Family 17 235
Mitogen-activated protein kinase 14 Inhibitor Losmapimod Family 5 154
Coagulation factor X Inhibitor Otamixaban Family 9 21
Gamma-aminobutyric acid receptor Ligand E-2007 Family 7 118
Growth hormone receptor Ligand EP-51216 Family 34 390
D(3) dopamine receptor Ligand SB-277011 Family 13 178
Substance-P receptor Ligand TAK-637 Family 18 63
ABC294640 family 5 75
CP-18770 family 6 27
C-C chemokine receptor type 3 Ligand YM-344031 Family 19 106
XL-888 family 16 85
cGMP-dependent 3',5'-cyclic phosphodiesterase Inhibitor CP-461... 4 34
Macrophage metalloelastase Inhibitor PF-00356231 Family 5 79
Carbonic anhydrase 2 Inhibitor N-[2-(1h-indol-5-yl)-butyl]-4-s... 12 70
Integrin beta-3 Inhibitor Elarofiban Family 28 45
cGMP-inhibited 3',5'-cyclic phosphodiesterase A and Cytochrome... 9 40
Cytochrome P450 11B1, mitochondrial and Aromatase Inhibitor 5-... 3 5
Histone deacetylase 1 and Histone deacetylase 2 Inhibitor N-(4... 4 21
Melanocortin receptor 3 and Melanocortin receptor 4 Ligand C[n... 12 10
Cholecystokinin receptor type A Ligand VL-0395 Family 12 117
Transient receptor potential cation channel subfamily V member... 6 23
D(4) dopamine receptor Ligand ABT-670 Family 4 14
Cannabinoid receptor 1 Ligand N-phenyl-5,6-dip-tolylpyrazine-2... 11 26
Melanocortin receptor 3 and Melanocortin receptor 4 Ligand C[c... 20 18
C-C chemokine receptor type 5 Ligand GT-1282 Family 21 14
Bifunctional epoxide hydrolase 2 Inhibitor N-(3,3-diphenyl-pro... 6 14
Hydroxycarboxylic acid receptor 2 Ligand 2-(6-phenylhexyl)pyri... 4 11
Mitogen-activated protein kinase 14 Inhibitor N-(4-fluorobenzy... 19 32
Steroid 17-alpha-hydroxylase/17,20 lyase and Cytochrome P450 1... 2 4
Sodium channel protein type 10 subunit alpha Ligand N-benzyl-5... 11 46
Endothelin B receptor Ligand IRL-2500 Family 34 87
Vasopressin V1a receptor and Vasopressin V1b receptor Ligand D... 10 19
Vasopressin V2 receptor Ligand YM-35278 Family 33 38
RAC-alpha serine/threonine-protein kinase and Cyclin-dependent... 3 7
Rho-associated protein kinase 2 and cAMP-dependent protein kin... 2 7
Glucocorticoid receptor ligand SureCN3283777 family 1 0
Prostaglandin E2 receptor EP3 subtype and Prostaglandin E2 rec... 4 20
Cholecystokinin receptor type A ligand A-65186 family 2 6
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 13 0
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 4 8
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 2 1
Peptide deformylase inhibitor (2R)-N-[(2S)-3,3-dimethyl-1-oxo-... 2 1
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 3 0
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 6 4
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 6 3
Bifunctional epoxide hydrolase 2 inhibitor AGN-PC-04SK7R family 3 3
Substance-K receptor ligand N-[1-[[(2R)-5-[4-(oxan-4-ylmethyl)... 2 0
Cathepsin L1 and Cathepsin S inhibitor N-[(2S)-4-methyl-1-oxo-... 3 3
Mast/stem cell growth factor receptor Kit and Mitogen-activate... 4 2
cAMP-specific 3',5'-cyclic phosphodiesterase 4B and cAMP-speci... 5 5
Mitogen-activated protein kinase 14 and Mitogen-activated prot... 1 1
Prostaglandin D2 receptor 2 ligand 2-[1-(4-benzamidobenzoyl)is... 4 9
Prostaglandin D2 receptor 2 ligand 2-[1-[4-[[(E)-3-(3,4-dichlo... 6 1
cAMP-specific 3',5'-cyclic phosphodiesterase 4B and cAMP-speci... 5 2
Pol polyprotein inhibitor AC1LAHQ9 family 8 15
cAMP-specific 3',5'-cyclic phosphodiesterase 4B and cAMP-speci... 2 3
Cannabinoid receptor 1 ligand N-(cyclobutylmethyl)-3-[[4-(meth... 1 1
Cannabinoid receptor 1 and Cytochrome P450 3A4 ligand N-(oxan-... 2 0
Integrin alpha-V and Integrin beta-6 inhibitor 3-[[2-[4-[(4-me... 4 3
Stromelysin-1 and 72 kDa type IV collagenase inhibitor (2S,4R)... 2 2
Platelet-activating factor receptor ligand (1-ethylindol-3-yl)... 17 13
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-2-[(1-benz... 2 1
Neprilysin and Angiotensin-converting enzyme inhibitor (2S)-2-... 2 3
Integrin beta-1 and Integrin alpha-5 inhibitor 2-[(2,6-dimethy... 9 1
Integrin beta-1 and Integrin alpha-5 inhibitor (2S)-3-[4-[4-[[... 2 0
Thromboxane-A synthase inhibitor SureCN9825871 family 6 3
Integrin beta-3 and Integrin alpha-V inhibitor (2S)-3-[4-[3-[[... 1 0
Integrin alpha-V inhibitor (2R)-3-(pyridine-3-carbonylamino)-2... 1 0
Integrin beta-1 and Integrin alpha-5 inhibitor (2S)-3-[4-[5-[[... 1 0
Neuromedin-K receptor ligand SureCN6447482 family 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00311861 CHEMBL421253 Bioactive (2S)-2-[[4-[[benzenesulfonyl(pyridin-3-yl)amino]methyl]-2-(2-methylphenyl)benzoyl]amino]-4-methylsulfanylbutanoic acid
CFAMM00311853 CHEMBL124229 Bioactive SureCN6772568
CFAMM00311866 CHEMBL164408 Bioactive (2S)-2-[[4-[(E)-1-cyano-2-pyridin-3-ylethenyl]-2-(2-methylphenyl)benzoyl]amino]-4-methylsulfanylbutanoic acid
CFAMM00311846 CHEMBL159324 Bioactive (2S)-2-[[4-[(Z)-1-cyano-2-pyridin-3-ylethenyl]-2-(2-methylphenyl)benzoyl]amino]-4-methylsulfanylbutanoic acid
CFAMM00311859 CHEMBL433519 Bioactive (2S)-2-[[4-[(E)-2-(4-chloropyridin-3-yl)ethenyl]-2-(2-methylphenyl)benzoyl]amino]-4-methylsulfanylbutanoic acid
CFAMM00311858 CHEMBL135544 Bioactive SureCN6774483
CFAMM00311845 CHEMBL330822 Bioactive SureCN6897267
CFAMM00311871 CHEMBL333575 Bioactive (2S)-2-[[4-[[benzyl-(5-fluoropyridin-3-yl)amino]methyl]-2-(2-methylphenyl)benzoyl]amino]-4-methylsulfanylbutanoic acid
CFAMM00311851 CHEMBL436440 Bioactive (2S)-2-[[4-[(E)-2-[4-(adamantane-1-carbonyl)pyridin-3-yl]ethenyl]-2-(2-methylphenyl)benzoyl]amino]-4-methylsulfanylbutanoic acid
CFAMM00311857 CHEMBL423459 Bioactive (2S)-2-[[2-(2-methylphenyl)-4-(2-pyridin-3-ylethyl)benzoyl]amino]-4-methylsulfanylbutanoic acid
CFAMM00311863 CHEMBL348838 Bioactive (2S)-2-[[4-[(E)-2-(5-benzylpyridin-3-yl)ethenyl]-2-(2-methylphenyl)benzoyl]amino]-4-methylsulfanylbutanoic acid
CFAMM00311869 CHEMBL123019 Bioactive SureCN7606397
CFAMM00311849 CHEMBL350566 Bioactive SureCN6771835
CFAMM00311842 CHEMBL349051 Bioactive (2S)-2-[[2-(2-methylphenyl)-4-[(E)-2-pyridin-3-ylethenyl]benzoyl]amino]-4-methylsulfanylbutanoic acid
CFAMM00311855 CHEMBL164259 Bioactive (2S)-2-[[4-[(E)-2-(4-benzoylpyridin-3-yl)ethenyl]-2-(2-methylphenyl)benzoyl]amino]-4-methylsulfanylbutanoic acid
CFAMM00311868 CHEMBL164366 Bioactive (2S)-2-[[4-[(E)-2-isoquinolin-4-ylethenyl]-2-(2-methylphenyl)benzoyl]amino]-4-methylsulfanylbutanoic acid
CFAMM00311848 CHEMBL108161 Bioactive SureCN6778059

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27514 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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