CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM4696
Family Name Nuclear receptor ROR-gamma and Menin ligand CHEMBL1432265 family
No. of Seeds 1 No. of Other Members 18
Family Centroid CFAMM00358256 Functional Category Bioactive with Natural Product
Superfamily Prelamin-A/C and Menin Binder Superfamily 6
Class Class 2872

Cousin Family NamesSeedsMembers
Beta-1 adrenergic receptor Ligand Acebutolol Family 2 27
Sodium channel protein type 5 subunit alpha Ligand Encainide F... 4 248
Histamine H1 receptor Ligand Tranilast Family 5 125
D(4) dopamine receptor Ligand PD-165167 Family 2 96
Cinitapride family 4 22
5-hydroxytryptamine receptor 1A Ligand (s)-way 100135 Family 94 975
Alpha-2C adrenergic receptor Ligand ARC239 Family 15 23
CGMP-inhibited 3',5'-cyclic phosphodiesterase Inhibitor Cilost... 6 202
Amine oxidase [flavin-containing] A Inhibitor Ethyl 4-(2-oxo-2... 4 117
Leukotriene A-4 hydrolase Inhibitor N5-[4-(phenylmethoxy)pheny... 7 49
Cytochrome P450 1B1 Inhibitor N-(2,4-dimethoxy-phenyl)-3,5-dim... 1 110
Substance-K receptor Ligand MEN-14933 Family 13 154
Alpha-1A adrenergic receptor Ligand Upidosin Family 8 46
Cannabinoid receptor 1 Ligand N-(4-methoxyphenyl)oleamide Family 4 23
Amyloid beta A4 protein Inhibitor 6-iodo-4'-methylaminoflavone... 3 33
Histone deacetylase 2 Inhibitor N-(4-amino-3'-methoxybiphenyl-... 3 49
Leukotriene A-4 hydrolase Inhibitor N5-[4-(4-(3-furyl)phenoxy)... 7 71
Enoyl-[acyl-carrier-protein] reductase [NADH] Inhibitor N-(3,5... 1 2
Proto-oncogene tyrosine-protein kinase receptor Ret Ligand (z)... 1 60
Galanin receptor type 1 and Galanin receptor type 2 Ligand Gal... 55 132
Reverse transcriptase Inhibitor 10-propyl-10h-dibenzo[b,f][1,4... 9 60
Beta-ketoacyl-acyl carrier protein synthase III Inhibitor 2-(4... 2 6
Tyrosinase Inhibitor 1-(4-(benzyloxy)phenyl)-3-hydroxyurea Family 9 23
Metabotropic glutamate receptor 5 Ligand N-(3-(3-cyanobenzamid... 2 13
Gamma-aminobutyric acid receptor Ligand 2-(2-amino-phenyl)-6-m... 4 23
Integrin beta-3 and Integrin alpha-IIb inhibitor AGN-PC-02INEQ... 6 6
D(3) dopamine receptor and D(2) dopamine receptor ligand (E)-N... 2 2
Thyroid hormone receptor beta ligand SureCN8800248 family 3 10
Transient receptor potential cation channel subfamily V member... 1 2
Prostaglandin D2 receptor 2 ligand 2-[4-methoxy-3-[2-[[(1S)-1-... 5 28
Neuronal acetylcholine receptor subunit alpha-7 and Potassium ... 1 2
Cathepsin K and Cathepsin L1 inhibitor 4-ethyl-N-[(2S)-1-[2-(4... 7 10
Sphingosine 1-phosphate receptor 1 ligand 2-methoxy-N-[(4-phen... 2 23
Bifunctional epoxide hydrolase 2 inhibitor 3-[4-[[4-(trifluoro... 5 22
Leukotriene A-4 hydrolase inhibitor SureCN5313952 family 4 1
Capsid scaffolding protein inhibitor AC1MHP20 family 3 3
Trace amine-associated receptor 1 ligand ZINC07609882 family 2 0
Amine oxidase [flavin-containing] B and Adenosine receptor A2b... 2 2
Dihydroorotate dehydrogenase (quinone), mitochondrial inhibito... 2 0
Caspase-3 inhibitor AGN-PC-00ELYM family 3 2
Disintegrin and metalloproteinase domain-containing protein 17... 1 0
Major prion protein and Microtubule-associated protein tau inh... 2 10
Glycogen synthase kinase-3 beta and Glycogen synthase kinase-3... 4 1
Nuclear receptor ROR-gamma and Lethal factor ligand NSC211094 ... 1 3
Glucagon receptor ligand 2-chloro-N-[[3-chloro-4-(4-chlorophen... 1 7
3,5-bis[[2-(4-methoxyphenoxy)acetyl]amino]benzoate NP Agn-pc-0... 1 1


CFAM Mol ID

External ID

Functional Category

Molecule Name


Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

26185 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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