CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM4705
Family Name Histamine H4 receptor ligand 2-[[6-iodo-2-(4-methylpiperazin-1-yl)quinazolin-4-yl]amino]-N-phenylethanesulfonamide family
No. of Seeds 4 No. of Other Members 2
Family Centroid CFAMM00358286 Functional Category Bioactive
Superfamily Growth hormone secretagogue receptor type 1 and cAMP Binder Superfamily
Class Class 857

Cousin Family NamesSeedsMembers
Histamine H1 receptor Ligand Mizolastine Family 14 603
C-X-C chemokine receptor type 4 Ligand AMD-070 Family 12 800
Neuropeptide Y receptor type 5 Ligand CGP71683A Family 5 74
Transient receptor potential cation channel subfamily V member... 15 457
Reverse transcriptase Inhibitor Dapivirine Family 5 72
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 14 234
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 35 270
GDC-0349 family 44 77
JAK Inhibitor Momelotinib Family 33 83
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 8 55
Corticotropin-releasing factor receptor 1 Ligand CP-154526 Family 9 29
Corticotropin-releasing factor receptor 1 Ligand CRA1000 Family 4 39
D(4) dopamine receptor Ligand L-745,870 Family 30 205
5-hydroxytryptamine receptor 2B Ligand MT-500 Family 8 39
Epidermal growth factor receptor and Receptor tyrosine-protein... 11 138
Peptide deformylase, mitochondrial Inhibitor 5-phenylsulfanyl-... 5 23
Beta-secretase 1 Inhibitor N~3~-(3-pyridin-3-ylbenzyl)pyridine... 31 66
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 4 32
Peptide deformylase, mitochondrial Inhibitor 5-phenethyl-quina... 5 14
Epidermal growth factor receptor Ligand PD-158780 Family 98 89
Epidermal growth factor receptor Ligand N*4*-(3-bromo-phenyl)-... 7 11
Cyclin-dependent kinase 4 Inhibitor 1-pyridin-2-yl-3-quinolin-... 2 5
Scytalone dehydratase Inhibitor Isoquinolin-1-yl-(3-phenyl-pro... 4 9
Epidermal growth factor receptor Ligand Benzo[g]quinazolin-4-y... 5 3
Epidermal growth factor receptor Ligand (3-bromo-phenyl)-quina... 7 5
Cyclin-dependent kinase 1 Inhibitor CGP-60474 Family 14 103
Histamine H3 receptor Ligand 2-(4-isopropyl-piperazin-1-yl)-qu... 17 29
Epidermal growth factor receptor Ligand N4-(3-chlorophenyl)qui... 7 39
Cyclin-dependent kinase 2 and Mitogen-activated protein kinase... 7 30
Adenosine receptor A3 Ligand 1-(2-(diethylamino)quinazolin-4-y... 2 9
Mitogen-activated protein kinase 14 and Tyrosine-protein kinas... 3 9
Adenosine receptor A1 and Adenosine receptor A2a Ligand N-(2,6... 22 18
Cathepsin K Inhibitor 4-phenyl-6-propylpyrimidine-2-carbonitri... 6 10
Adenosine receptor A1 and Adenosine receptor A2a Ligand 4-amin... 4 11
Macrophage migration inhibitory factor Inhibitor 4-iodo-6-phen... 5 4
Oestrogen receptor Ligand 4-benzyl-2,6-diisobutylamino-pyrimid... 5 37
Histamine H4 receptor Ligand A-943931 Family 14 11
RAF proto-oncogene serine/threonine-protein kinase Inhibitor L... 219 124
Prostaglandin G/H synthase 2 Inhibitor GW-637185X Family 27 48
Urotensin-2 receptor Ligand Palosuran Family 4 4
Sodium-dependent serotonin transporter Inhibitor 6-nitroquipaz... 18 21
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 4 22
Sodium-dependent serotonin transporter Inhibitor 6-chloro-2-pi... 5 35
Sodium channel protein type 1 subunit alpha and Sodium channel... 10 14
Corticotropin-releasing factor receptor 1 Ligand N-mesityl-6-m... 3 2
Amine oxidase [flavin-containing] A Inhibitor 3-benzyl-n-(2-mo... 2 3
Acetylcholinesterase Inhibitor N-benzyl-2-morpholinopyrimidin-... 6 16
Acetylcholinesterase and Cholinesterase Inhibitor Huprine-tacr... 62 27
Dihydrofolate reductase and Bifunctional dihydrofolate reducta... 3 8
Tyrosine-protein kinase JAK2 inhibitor AGN-PC-07ZB89 family 6 13
Inhibitor of nuclear factor kappa-B kinase subunit beta inhibi... 1 7
Sphingosine 1-phosphate receptor 1 and Sphingosine 1-phosphate... 4 14
Dihydrofolate reductase and Bifunctional dihydrofolate reducta... 3 9
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK1 ... 2 0
5-hydroxytryptamine receptor 6 ligand AGN-PC-03P3TZ family 6 88
Neuronal acetylcholine receptor subunit alpha-7 ligand 2-(4-cy... 1 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 4 27
Carbonic anhydrase 9 and Carbonic anhydrase 2 inhibitor AGN-PC... 1 0
Beta-3 adrenergic receptor and Beta-2 adrenergic receptor liga... 4 1
Growth hormone secretagogue receptor type 1 and Dihydrofolate ... 3 6
Survival motor neuron protein inhibitor CHEMBL1581561 family 1 3
Glutamate receptor ionotropic, NMDA 2D and Glutamate receptor ... 3 3
Histamine H4 receptor ligand 4-[(3R)-3-(methylamino)pyrrolidin... 7 6
ALK tyrosine kinase receptor and Insulin receptor ligand N-[(1... 3 6
Neuropeptide Y receptor type 5 ligand SureCN8898853 family 2 3
Tyrosine-protein kinase JAK2 inhibitor N-tert-butyl-3-[2-[3-fl... 4 14
Mu-type opioid receptor and Kappa-type opioid receptor ligand ... 3 0
Vascular endothelial growth factor receptor 2 ligand urea deri... 3 9
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A ... 1 1
Vascular endothelial growth factor receptor 2 ligand urea deri... 2 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 1 8
Aurora kinase A and Aurora kinase B inhibitor 2-[[5-chloro-2-[... 3 7
Carbonic anhydrase 9 and Carbonic anhydrase 2 inhibitor AGN-PC... 1 0
D(3) dopamine receptor and D(2) dopamine receptor ligand SureC... 3 0
Growth hormone secretagogue receptor type 1 ligand AGN-PC-0760... 4 0
Growth hormone secretagogue receptor type 1 ligand SureCN63605... 5 7
cAMP-specific 3',5'-cyclic phosphodiesterase 4B inhibitor 2-[4... 5 5
Translocator protein inhibitor N-butan-2-yl-4-(2-chlorophenyl)... 14 12
Serine/threonine-protein kinase SMG1 and Serine/threonine-prot... 10 0
Serine/threonine-protein kinase SMG1 and Cyclin-dependent kina... 3 1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 1 0
Histamine H4 receptor and Histamine H3 receptor ligand 7-cyclo... 2 0
Mitogen-activated protein kinase 8 and Mitogen-activated prote... 4 5
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 8 inhibitor AG... 3 1
Cathepsin K and Cathepsin S inhibitor SureCN4138353 family 3 0
C-X-C chemokine receptor type 3 ligand 1-[3-[[(1R,5S)-3-[[7-(t... 3 1
Prostaglandin G/H synthase 2 inhibitor 4-N,4-N-diethyl-2-(4-me... 5 1
Dihydrofolate reductase inhibitor WR 158122 family 1 0
Prostaglandin G/H synthase 2 inhibitor 6-ethoxy-2-(4-methylsul... 5 1
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 3 1
Histamine H4 receptor and Histamine H1 receptor ligand 6-chlor... 1 0
Neuropeptide Y receptor type 5 ligand 1-methylsulfonyl-N-(2-ph... 4 0
Dihydrofolate reductase and Bifunctional dihydrofolate reducta... 1 0
Prostaglandin G/H synthase 2 and Prostaglandin G/H synthase 1 ... 3 0
Histamine H4 receptor ligand 2-[[6-chloro-2-(4-methylpiperazin... 7 2
D(4) dopamine receptor and D(2) dopamine receptor ligand SureC... 1 2
P2Y purinoceptor 14 inhibitor AGN-PC-0A9S8H family 3 2
Corticotropin-releasing factor receptor 1 ligand 5-N,5-N-bis(c... 2 0
Coagulation factor X and Prothrombin inhibitor SureCN6578740 f... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00358286 CHEMBL592434 Bioactive 2-[[6-iodo-2-(4-methylpiperazin-1-yl)quinazolin-4-yl]amino]-N-phenylethanesulfonamide
CFAMM00358284 CHEMBL591496 Bioactive 2-[[2-(4-methylpiperazin-1-yl)-5-(trifluoromethyl)quinazolin-4-yl]amino]-N-phenylethanesulfonamide
CFAMM00358288 CHEMBL1433148 Bioactive T5344218

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27513 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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