CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM47068
Family Name Glutamate receptor ionotropic, kainate 1 and Glutamate receptor 1 ligand (2S)-2-amino-3-(2,4-dioxoquinazolin-1-yl)propanoic acid family
No. of Seeds 1 No. of Other Members 12
Family Centroid CFAMM00529219 Functional Category Bioactive with Natural Product
Superfamily Arachidonate 5-lipoxygenase Inhibitor Isaindigotone Superfamily
Class Class 252

Cousin Family NamesSeedsMembers
Mu-type opioid receptor Ligand Fentanyl Family 9 647
5-hydroxytryptamine 2 receptor Ligand Ketanserin Family 10 253
Integrin alpha-4 Inhibitor R1295 Family 18 59
K-604 family 4 71
Integrin alpha-4 Inhibitor BIO-1211 Family 16 83
Integrin beta-3 Inhibitor SB-208651 Family 9 28
Cholecystokinin receptor type A Ligand VL-1499 Family 12 133
Voltage-dependent T-type calcium channel subunit alpha-1I Liga... 7 35
Arachidonate 5-lipoxygenase Inhibitor Isaindigotone Family 1 0
cGMP-inhibited 3',5'-cyclic phosphodiesterase A Inhibitor Benz... 3 12
cAMP-specific 3',5'-cyclic phosphodiesterase 4B Inhibitor 3-(2... 2 2
Phospholipase D1 Inhibitor Halopemide Family 17 111
D(2) dopamine receptor Ligand PD-168077 Family 6 5
Cellular tumor antigen p53 and Beta-lactamase inhibitor CHEMBL... 1 53
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 2 2
Histone deacetylase and Histone deacetylase 3 inhibitor (3S,6S... 2 4
C-C chemokine receptor type 2 ligand N-[2-[[(2S,3S)-1-[(2,4-di... 13 8
Muscarinic acetylcholine receptor M2 and Muscarinic acetylchol... 5 19
Glycogen phosphorylase, liver form inhibitor SureCN5195475 family 9 5
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 2 3
Beta-lactamase inhibitor (1R,5S)-4-[(4-carbamoylphenyl)carbamo... 3 2
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 1 0
Aldose reductase inhibitor (4R)-6-fluoro-3-methylspiro[1H-quin... 4 16


External ID

Functional Category

Molecule Name

CFAMM00529219 CHEMBL508818 Bioactive (2S)-2-amino-3-(2,4-dioxoquinazolin-1-yl)propanoic acid

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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