CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

Family Name Mitogen-activated protein kinase 14 inhibitor 6-[3-amino-5-(2-fluorophenyl)-1H-pyrazol-4-yl]-N-propan-2-yl-1,3-benzothiazol-2-amine family
No. of Seeds 4 No. of Other Members 9
Family Centroid CFAMM00311971 Functional Category Bioactive
Superfamily Cytochrome P450 26A1 Inhibitor Rambazole Superfamily
Class Class 1124

Cousin Family NamesSeedsMembers
Tyrosine-protein kinase Lck and Aurora kinase B Inhibitor VX-6... 28 56
Cytochrome P450 26A1 Inhibitor Rambazole Family 7 77
PF-3758309 family 1 8
C-C chemokine receptor type 4 Ligand N-(4-tert-butylthiazol-2-... 3 9
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 6 55
RAC-alpha serine/threonine-protein kinase and Cyclin-dependent... 4 15
RAC-alpha serine/threonine-protein kinase and Cyclin-dependent... 2 7
Neuropeptide Y receptor type 5 ligand N-[[(1S,5R)-3-(1-phenyle... 5 1
Mitogen-activated protein kinase 14 inhibitor AGN-PC-07ZXHN fa... 2 4
Mitogen-activated protein kinase 14 and LIM domain kinase 1 in... 4 19
Glycogen synthase kinase-3 beta and Dual specificity protein k... 4 5
Mitogen-activated protein kinase 10 and Mitogen-activated prot... 2 18
Metabotropic glutamate receptor 4 and Potassium voltage-gated ... 2 15
3-phosphoinositide-dependent protein kinase 1 and MAP kinase-a... 1 5
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 2 3
D(3) dopamine receptor and D(2) dopamine receptor ligand 6-N-[... 3 0
Glucocorticoid receptor ligand 3-(1H-indol-5-yl)-2,2-dimethyl-... 2 7
Serine/threonine-protein kinase pim-1 and Serine/threonine-pro... 3 6
Inhibitor of nuclear factor kappa-B kinase subunit beta and In... 2 1
Epidermal growth factor receptor and Vascular endothelial grow... 7 0
Epidermal growth factor receptor and Vascular endothelial grow... 3 1
Transient receptor potential cation channel subfamily V member... 1 0
D(2) dopamine receptor ligand 7-[(1-methylpyrazol-4-yl)methyl]... 1 1
Mitogen-activated protein kinase 14 inhibitor 6-[2-(3-chloroph... 1 1


External ID

Functional Category

Molecule Name

CFAMM00311971 CHEMBL255470 Bioactive 6-[3-amino-5-(2-fluorophenyl)-1H-pyrazol-4-yl]-N-propan-2-yl-1,3-benzothiazol-2-amine
CFAMM00311979 CHEMBL1081829 Bioactive (2S)-1-N-[5-(1H-indazol-5-yl)-1,3-thiazol-2-yl]-3-[4-(trifluoromethyl)phenyl]propane-1,2-diamine
CFAMM00311970 CHEMBL257585 Bioactive 6-[3-amino-5-(2-fluorophenyl)-1H-pyrazol-4-yl]-N-[(2S)-butan-2-yl]-1,3-benzothiazol-2-amine
CFAMM00311969 CHEMBL404115 Bioactive 6-[3-amino-5-(2-fluorophenyl)-1H-pyrazol-4-yl]-N-[(2R)-butan-2-yl]-1,3-benzothiazol-2-amine

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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