CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

Family Name Prothrombin and Tissue-type plasminogen activator inhibitor CHEMBL96376 family
No. of Seeds 10 No. of Other Members 5
Family Centroid CFAMM00311993 Functional Category Bioactive with Natural Product
Superfamily Growth hormone secretagogue receptor type 1 Ligand TZP-101 Superfamily
Class Class 412

Cousin Family NamesSeedsMembers
Serine/threonine-protein kinase PLK1 Inhibitor On Fa... 16 138
Growth hormone secretagogue receptor type 1 Ligand TZP-101 Family 28 263
Extracellular calcium-sensing receptor Ligand Nps 568 Family 5 54
Kappa-type opioid receptor Ligand ICI-204448 Family 7 26
Neutrophil elastase inhibitor phenyl N-[(2S)-1-[(2S)-2-[[(3S)-... 10 4
Prothrombin and Tissue-type plasminogen activator inhibitor CH... 11 4
Prothrombin inhibitor AGN-PC-09QMX5 family 2 3
Dipeptidyl peptidase 4 and Seprase inhibitor (2R)-2-[4-[[[(2S)... 17 19
Prostaglandin D2 receptor 2 ligand AGN-PC-00DI7H family 6 8
Prostaglandin D2 receptor 2 ligand SureCN1713638 family 2 1
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 11 6
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand N-[(2... 10 12
Corticosteroid 11-beta-dehydrogenase isozyme 1 and Corticoster... 6 22
Baculoviral IAP repeat-containing protein 3 and E3 ubiquitin-p... 7 1
Motilin receptor ligand SureCN74051 family 1 0
C-C chemokine receptor type 1 ligand 2-[(2S)-3-(5-chlorospiro[... 2 3
Melanin-concentrating hormone receptor 1 and Potassium voltage... 1 0
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 1 0
Prothrombin and Trypsin-1 inhibitor AGN-PC-073O5X family 3 1
Stromelysin-1 and Interstitial collagenase inhibitor (2R)-2-[4... 4 1
Kappa-type opioid receptor ligand AGN-PC-03TFVP family 1 10
Cathepsin K and Cathepsin L1 inhibitor dipeptidyl nitrile, 16c... 1 0
Scytalone dehydratase inhibitor 2-cyano-N-[(1S,2R)-1-(2-cyanop... 5 0
Growth hormone secretagogue receptor type 1 ligand N-benzyl-2-... 5 19


External ID

Functional Category

Molecule Name

CFAMM00311999 CHEMBL96893 Bioactive [2-[[[(2S)-1-[(2S)-2-amino-2-cyclohexylacetyl]pyrrolidine-2-carbonyl]amino]methyl]-4-chlorophenyl] N-ethylcarbamate
CFAMM00311991 CHEMBL108202 Bioactive (2S)-1-[(2R)-2-amino-2-cyclohexylacetyl]-N-[[5-chloro-2-[2-(cyclopropylamino)-2-oxoethoxy]phenyl]methyl]pyrrolidine-2-carboxamide
CFAMM00312005 CHEMBL93315 Bioactive SureCN5844892
CFAMM00311990 CHEMBL327115 Bioactive ethyl 2-[2-[[[(2S)-1-[(2R)-2-amino-2-cyclohexylacetyl]pyrrolidine-2-carbonyl]amino]methyl]-4-chlorophenoxy]acetate
CFAMM00311995 CHEMBL94622 Bioactive CHEMBL94622
CFAMM00312002 CHEMBL2204325 Bioactive CHEMBL2204325
CFAMM00312001 CHEMBL1236167 Bioactive T76
CFAMM00311993 CHEMBL96376 Bioactive CHEMBL96376
CFAMM00311992 CHEMBL108717 Bioactive (2S)-1-[(2R)-2-amino-2-cyclohexylacetyl]-N-[[2-(2-amino-2-oxoethoxy)-5-chlorophenyl]methyl]pyrrolidine-2-carboxamide

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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