CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM4819
Family Name 5-hydroxytryptamine receptor 2A and D(2) dopamine receptor ligand AGN-PC-074OLD family
No. of Seeds 2 No. of Other Members 4
Family Centroid CFAMM00256674 Functional Category Bioactive with Natural Product
Superfamily Aldose reductase and Arachidonate 15-lipoxygenase Binder Superfamily
Class Class 1997

Cousin Family NamesSeedsMembers
5-hydroxytryptamine receptor 1B ligand triptan Almotriptan Family 8 438
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 4 171
D(1B) dopamine receptor Ligand LE-300 Family 65 452
Histone deacetylase 1 Inhibitor Panobinostat Family 5 93
D(2) dopamine receptor and D(3) dopamine receptor Ligand 4-(4-... 6 48
Platelet-derived growth factor receptor alpha and Platelet-der... 5 48
Steroid 17-alpha-hydroxylase/17,20 lyase and Cytochrome P450 1... 7 16
Mitogen-activated protein kinase 14 Inhibitor 4-(2-ethyl-4-m-t... 14 41
Indoleamine 2,3-dioxygenase 1 Inhibitor N-[2-(indol-3-yl)ethyl... 2 2
Inosine-5'-monophosphate dehydrogenase 2 Inhibitor 3-(thiophen... 9 66
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 14 19
Histamine H3 receptor Ligand ST-1025 Family 2 22
Sodium-dependent serotonin transporter Inhibitor 3-(3-aminocyc... 94 23
5-hydroxytryptamine receptor 2A and Amine oxidase [flavin-cont... 10 18
Arachidonate 15-lipoxygenase Inhibitor PD-146176 Family 1 3
Prostaglandin G/H synthase 2 Inhibitor 2-(4-(methylsulfonyl)ph... 7 33
Acetylcholinesterase and Cholinesterase Inhibitor Huprine-tacr... 62 27
Dipeptidyl peptidase 1 inhibitor (2S)-2-amino-N-[(1S)-1-cyano-... 2 14
Histamine H3 receptor and Potassium voltage-gated channel subf... 6 20
Neuropeptide S receptor and Prelamin-A/C ligand CHEMBL1367658 ... 1 7
Histamine H3 receptor and Potassium voltage-gated channel subf... 6 14
Histamine H1 receptor and Cytochrome P450 2D6 ligand 2-[3-[(1R... 1 10
5-hydroxytryptamine receptor 6 ligand CHEMBL1950756 family 8 8
Prostaglandin G/H synthase 2 and Prostaglandin G/H synthase 1 ... 4 0
Nuclear receptor ROR-gamma and Niemann-Pick C1 protein ligand ... 1 12
5-hydroxytryptamine receptor 7 and 5-hydroxytryptamine recepto... 3 7
Serine/threonine-protein kinase D3 and Protein kinase C delta ... 3 10
Substance-K receptor and Cytochrome P450 2D6 ligand 158848-32-... 4 4
Histamine H1 receptor and Cytochrome P450 2D6 ligand N-methyl-... 1 0
Sodium-dependent serotonin transporter inhibitor SureCN9171444... 2 0
Neuromedin-K receptor ligand 3-methylsulfinyl-N-[(1S)-1-phenyl... 3 5
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 2 0
5-hydroxytryptamine receptor 6 ligand SureCN3147604 family 7 6
Sigma non-opioid intracellular receptor 1 ligand SureCN7434677... 1 0
Sodium-dependent serotonin transporter inhibitor 3-[[(3S)-1-az... 1 1
5-hydroxytryptamine receptor 6 ligand 1-(5-bromothiophen-2-yl)... 4 0
Histone deacetylase 1 inhibitor 5-[5-[[(2-chlorophenyl)methyla... 4 1
5-hydroxytryptamine receptor 6 ligand 2-methyl-5-methylsulfany... 1 1
Metabotropic glutamate receptor 5 ligand 3-methyl-1-(2-thiophe... 2 1
Epidermal growth factor receptor and Vascular endothelial grow... 14 19
Epidermal growth factor receptor and Vascular endothelial grow... 7 0
Glutamate receptor ionotropic, NMDA 1 and Glutamate receptor i... 3 4
5-hydroxytryptamine receptor 6 ligand 3,4-dichloro-N-[3-[[(2R)... 5 0
Protein kinase C theta type and Protein kinase C delta type in... 4 5
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 1 0
Prostaglandin G/H synthase 2 inhibitor SureCN6345015 family 6 1
5-hydroxytryptamine receptor 6 and Cytochrome P450 3A4 ligand ... 1 0
Vascular endothelial growth factor receptor 2 and Vascular end... 1 1
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor CHEMBL3... 1 9


CFAM Mol ID

External ID

Functional Category

Molecule Name


Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27525 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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