CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM4837
Family Name 5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine receptor 2A ligand 1-[2-[4-[6-fluoro-1-(4-fluorophenyl)indol-3-yl]piperidin-1-yl]ethyl]-3-propan-2-ylimidazolidin-2-one family
No. of Seeds 3 No. of Other Members 8
Family Centroid CFAMM00176103 Functional Category Bioactive
Superfamily Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform and Serine/threonine-protein kinase mTOR Inhibitor BEZ235 Superfamily
Class Class 147

Cousin Family NamesSeedsMembers
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 14 2769
D(2) dopamine receptor and D(1A) dopamine receptor ligand ergo... 12 720
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 4 171
Nicotinic acetylcholine receptor Ligand Nicotine Family 14 686
D(1A) dopamine receptor ligand ergot alkaloid Methylergonovine... 22 170
D(2) dopamine receptor ligand ergot alkaloid Cabergoline Family 5 74
D(2) dopamine receptor Ligand Sertindole Family 3 173
Histamine H1 receptor Ligand Pheniramine Family 10 380
Histamine H1 receptor Ligand Triprolidine Family 19 316
Histamine H1 receptor Ligand Mizolastine Family 14 603
Transient receptor potential cation channel subfamily V member... 15 158
C-X-C chemokine receptor type 4 Ligand AMD-070 Family 12 800
Hepatocyte growth factor receptor Ligand Arq 197 Family 10 400
Transient receptor potential cation channel subfamily V member... 16 295
Glycogen synthase kinase-3 beta and Protein kinase C beta type... 5 53
Transient receptor potential cation channel subfamily V member... 6 66
Calcitonin gene-related peptide type 1 receptor Ligand Telcage... 25 124
Cyclin-dependent kinase 4 Inhibitor PD-332991 Family 13 155
Potassium voltage-gated channel subfamily KQT member 1 Ligand ... 13 242
Growth hormone receptor Ligand EP-51216 Family 34 390
D(1B) dopamine receptor Ligand LE-300 Family 65 452
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 14 234
Aurora kinase B and Aurora kinase C Inhibitor GSK1070916 Family 53 580
Amg 423 family 7 47
Neuropeptide Y receptor type 5 Ligand Npy5ra-972 Family 6 29
C-C chemokine receptor type 3 Ligand YM-344031 Family 19 106
5-hydroxytryptamine receptor 2A Ligand RP-68303 Family 7 44
Lethal factor Inhibitor GM6001 Family 50 435
cGMP-dependent 3',5'-cyclic phosphodiesterase Inhibitor CP-461... 4 34
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 6 17
Somatostatin receptor type 2 Ligand L-054852 Family 13 88
5-hydroxytryptamine receptor 2B Ligand Sb 206553 Family 14 21
Beta-secretase 1 Inhibitor 6-[2-(1h-indol-6-yl)ethyl]pyridin-2... 10 43
Beta-secretase 1 Inhibitor N~3~-(3-pyridin-3-ylbenzyl)pyridine... 31 66
D(2) dopamine receptor and D(3) dopamine receptor Ligand 4-(4-... 6 48
Steroid 17-alpha-hydroxylase/17,20 lyase and Aromatase Inhibit... 18 109
Potassium voltage-gated channel subfamily H member 2 Ligand 5-... 5 14
Cyclin-dependent kinase 4 Inhibitor 1-pyridin-2-yl-3-quinolin-... 2 5
Arachidonate 5-lipoxygenase Inhibitor 2,4,5-triarylimidazole A... 3 16
Methionine aminopeptidase 2 Inhibitor 2-(pyridin-2-yl)-1h-benz... 6 19
Metabotropic glutamate receptor 5 Ligand 3-(4-pyridin-2-yl-imi... 6 5
cGMP-inhibited 3',5'-cyclic phosphodiesterase A and Cytochrome... 9 40
Adenosine receptor A3 Ligand 1-benzyl-1h-1,3,4b,9-tetraaza-flu... 19 165
RAC-gamma serine/threonine-protein kinase and Rho-associated p... 16 46
5-hydroxytryptamine receptor 6 Ligand 4-(1h-indol-1-ylsulfonyl... 7 79
DNA-dependent protein kinase catalytic subunit Inhibitor 2-mor... 2 6
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 3 2
Inosine-5'-monophosphate dehydrogenase 2 Inhibitor 1-methyl-1h... 6 24
Inosine-5'-monophosphate dehydrogenase 2 Inhibitor 1-(3-cyano-... 2 4
D(2) dopamine receptor and D(3) dopamine receptor Ligand 1-(4-... 10 48
Trypsin Inhibitor 1-benzyl-1h-indole-5-carboxamidine Family 4 3
Cholinesterase Inhibitor 9-[9-(beta-carboline-9-yl)nonyl]-beta... 7 7
Melanocortin receptor 3 and Melanocortin receptor 4 Ligand C[c... 20 18
RAF proto-oncogene serine/threonine-protein kinase Inhibitor L... 219 124
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 4 33
Protein kinase C theta type Inhibitor 4-(3h-indol-4-ylamino)-5... 2 2
Urotensin-2 receptor Ligand Palosuran Family 4 4
Steroid 17-alpha-hydroxylase/17,20 lyase and Cytochrome P450 1... 2 4
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 5 9
Sodium-dependent serotonin transporter Inhibitor 3-(3-aminocyc... 94 23
Ribosyldihydronicotinamide dehydrogenase [quinone] Inhibitor N... 6 10
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 3 29
Metabotropic glutamate receptor 5 Ligand 3-m-tolyl-1,5-naphthy... 6 10
Vasopressin V2 receptor Ligand YM-35278 Family 33 38
Acetylcholinesterase Inhibitor Infractopicrin Family 1 1
Metabotropic glutamate receptor 5 Ligand 5-((6-methylpyridin-2... 14 22
Histone deacetylase Inhibitor ST-5732 Family 8 6
Acetylcholinesterase and Cholinesterase Inhibitor Huprine-tacr... 62 27
Choline kinase alpha Inhibitor Bisquinolinium Derivative Family 10 7
Prothrombin inhibitor SureCN5855286 family 15 8
Prothrombin inhibitor SureCN5854779 family 4 9
Prothrombin inhibitor SureCN5856722 family 3 16
Transient receptor potential cation channel subfamily V member... 3 1
Tyrosine-protein kinase JAK3 and Tyrosine-protein kinase JAK2 ... 2 3
Bifunctional epoxide hydrolase 2 and Cytochrome P450 3A4 inhib... 1 13
Neuronal acetylcholine receptor subunit alpha-7 and Potassium ... 7 3
Bifunctional epoxide hydrolase 2 and Cytochrome P450 2C9 inhib... 1 1
Histamine H3 receptor and Potassium voltage-gated channel subf... 2 2
Gastrin/cholecystokinin type B receptor and Cholecystokinin re... 14 8
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 2 1
Histamine H3 receptor ligand 1-[1-[1-[(2-aminopyridin-4-yl)met... 16 9
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 1 0
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 7 10
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 11 20
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 10 1
D(2) dopamine receptor and 5-hydroxytryptamine receptor 2C lig... 2 3
Neuropeptide Y receptor type 5 and Potassium voltage-gated cha... 6 0
Cellular tumor antigen p53 and Microtubule-associated protein ... 1 8
Survival motor neuron protein and Menin inhibitor CHEMBL132797... 1 1
C-C chemokine receptor type 5 ligand SureCN1573831 family 4 3
5-hydroxytryptamine receptor 1A ligand 2-[4-(quinolin-2-ylmeth... 2 91
Prelamin-A/C and Survival motor neuron protein inhibitor CHEMB... 1 0
Inositol monophosphatase 1 and 15-hydroxyprostaglandin dehydro... 1 0
Prothrombin and Trypsin-1 inhibitor 2-[6-methyl-2-oxo-3-(2-pyr... 4 2
C-C chemokine receptor type 5 and Potassium voltage-gated chan... 21 32
Prostaglandin E synthase inhibitor AGN-PC-09QHBK family 3 1
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 6 2
Sigma non-opioid intracellular receptor 1 ligand SureCN7434677... 1 0
C-C chemokine receptor type 5 ligand methyl N-cyano-4-[2-[(1R,... 8 8
Renin and Potassium voltage-gated channel subfamily H member 2... 9 2
C-X-C chemokine receptor type 3 ligand (6aR,9R)-N-phenyl-4-(2-... 5 0
Smoothened homolog inhibitor (8aS)-N-[2-(3-cyanophenyl)pyridin... 3 4
Toll-like receptor 7 ligand 4-amino-1-[[6-[(2S)-2-(pyrrolidin-... 4 0
Tyrosine-protein kinase JAK1 inhibitor CHEMBL2206623 family 10 11
Neuronal acetylcholine receptor subunit alpha-7 ligand 1-(4-me... 1 0
Serine/threonine-protein kinase mTOR inhibitor 5-(2-amino-3H-b... 3 1
C-C chemokine receptor type 3 ligand 1-[(1R,2S)-2-[[3-[(4-fluo... 3 2
Mast/stem cell growth factor receptor Kit and Receptor-type ty... 8 3
Macrophage colony-stimulating factor 1 receptor and Vascular e... 2 3
Melanin-concentrating hormone receptor 1 and Melanin-concentra... 3 1
Melanin-concentrating hormone receptor 1 and 5-hydroxytryptami... 2 0
Dipeptidyl peptidase 4 inhibitor [(2S,4S)-4-(4-quinolin-4-ylpi... 5 8
Somatostatin receptor type 3 ligand tert-butyl 4-[(3R)-3-(5-ph... 2 2
D(4) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 2 1
Tyrosine-protein kinase JAK1 inhibitor CHEMBL2152412 family 8 0
Cholesteryl ester transfer protein inhibitor 1-[(1S)-1-(5-chlo... 1 4
Probable G-protein coupled receptor 142 ligand (2S)-N-(2-oxo-5... 2 1
Renin inhibitor (E)-but-2-enedioic acid;(3S,5R)-5-[4-(2-chloro... 6 8
C-C chemokine receptor type 2 and Potassium voltage-gated chan... 2 2
Fatty-acid amide hydrolase 1 inhibitor 1-[3-[4-(6-phenylhexyl)... 1 0
CGMP-dependent protein kinase inhibitor SureCN14561191 family 4 0
Serine/threonine-protein kinase mTOR inhibitor 1-ethyl-3-[4-[6... 4 1
Glucocorticoid receptor ligand 3,3,3-trifluoro-N-[(3S)-3-[1-(4... 10 4
Calcitonin gene-related peptide type 1 receptor ligand N-[2-(7... 16 0
Eukaryotic translation initiation factor 2-alpha kinase 3 and ... 4 0
Phospholipase D1 and Phospholipase D2 inhibitor SureCN10311349... 2 14
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 8 inhibitor (2... 2 2
C-C chemokine receptor type 3 and Cytochrome P450 2D6 ligand 1... 5 0
CGMP-dependent protein kinase inhibitor 1-[4-acetyl-3-[[4-[5-(... 2 0
D(2) dopamine receptor and 5-hydroxytryptamine receptor 2C lig... 1 0
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 2 2
Platelet-activating factor receptor ligand SureCN9853140 family 3 3
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 3 0
5-hydroxytryptamine receptor 1D ligand AGN-PC-01NTBS family 1 1
5-hydroxytryptamine receptor 3E and 5-hydroxytryptamine recept... 1 1
Gonadotropin-releasing hormone receptor ligand 1-[2-(3,5-dimet... 2 0
Cyclin-dependent kinase 2 and Potassium voltage-gated channel ... 12 7
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 3 4
Neuropeptide Y receptor type 5 ligand 1-methylsulfonyl-N-(4-py... 9 0
5-hydroxytryptamine receptor 3A ligand AGN-PC-077D8K family 3 1
CGMP-dependent protein kinase inhibitor AGN-PC-078XQ0 family 1 1
Melanin-concentrating hormone receptor 1 ligand SureCN4917950 ... 3 5
Melanin-concentrating hormone receptor 1 and Potassium voltage... 1 1
Melanin-concentrating hormone receptor 1 and Potassium voltage... 1 0
Tyrosine-protein kinase Lck inhibitor (3S)-3-[(1S)-1-[[4-(benz... 14 0
Neuropeptide Y receptor type 5 ligand AGN-PC-01NS1A family 7 0
Sterol O-acyltransferase 1 inhibitor SureCN7073167 family 4 2
D(2) dopamine receptor and 5-hydroxytryptamine receptor 2C lig... 1 0
N-formyl peptide receptor 2 ligand 1-(1-methyl-3-oxo-5-propan-... 3 1
Acyl-CoA:cholesterol acyltransferase inhibitor AGN-PC-00GCQW f... 2 1
Melanin-concentrating hormone receptor 1 and Potassium voltage... 4 2


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00359461 CHEMBL550068 Bioactive AGN-PC-07C5RX

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27518 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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