CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM4853
Family Name Disintegrin and metalloproteinase domain-containing protein 17 and Interstitial collagenase inhibitor (2R,3S)-N-[(2S)-3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl]-N'-hydroxy-2-(2-methylpropyl)-3-(quinoline-8-carbonylamino)butanediamide family
No. of Seeds 4 No. of Other Members 0
Family Centroid CFAMM00359534 Functional Category Bioactive
Superfamily Interstitial collagenase and Matrilysin Binder Superfamily
Class Class 295

Cousin Family NamesSeedsMembers
Receptor-type tyrosine-protein kinase FLT3 inhibitor indoline ... 4 151
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 14 2769
HIV protease Inhibitor Saquinavir Family 64 428
Reverse transcriptase Inhibitor Nevirapine Family 23 640
Gastrin/cholecystokinin type B receptor ligand peptide Pentaga... 26 1171
5-hydroxytryptamine receptor 3A Ligand Granisetron Family 26 212
Somatostatin receptor type 2 ligand octapeptide Octreotide Family 27 172
Cytochrome P450 11B1, mitochondrial Inhibitor Metyrapone Family 9 243
Sodium channel protein type 5 subunit alpha Ligand Disopyramid... 4 352
Indoleamine 2,3-dioxygenase 1 Inhibitor L-tryptophan Family 8 328
26S proteasome Inhibitor Bortezomib Family 7 65
SUR2-type K(ATP) channel Ligand Nicorandil Family 5 85
Prothrombin Inhibitor Ximelegatran Family 8 157
Hepatocyte growth factor receptor Ligand Arq 197 Family 10 400
Glycogen synthase kinase-3 beta and Protein kinase C beta type... 5 53
Glycogen phosphorylase, muscle form Inhibitor PSN357 Family 3 253
Neuromedin-K receptor Ligand SB222200 Family 17 235
Cholecystokinin receptor type A Ligand Tarazepide Family 6 323
Substance-P receptor Ligand GSK424887 Family 8 184
Poly [ADP-ribose] polymerase 1 Inhibitor AG-14699 Family 13 179
Mitogen-activated protein kinase 14 Inhibitor Losmapimod Family 5 154
Coagulation factor X Inhibitor Otamixaban Family 9 21
Glutamate receptor AMPA subtype Ligand CX-516 Family 9 24
Gamma-aminobutyric acid receptor Ligand E-2007 Family 7 118
Growth hormone receptor Ligand EP-51216 Family 34 390
D(3) dopamine receptor Ligand SB-277011 Family 13 178
Substance-P receptor Ligand TAK-637 Family 18 63
Histone deacetylase 1 Inhibitor Pyroxamide Family 4 13
TGF-beta receptor type-1 Ligand LY2157299 Family 13 56
CP-18770 family 6 27
Gastrin/cholecystokinin type B receptor Ligand PD136450 Family 53 117
C-C chemokine receptor type 3 Ligand YM-344031 Family 19 106
Lethal factor Inhibitor GM6001 Family 50 435
XL-888 family 16 85
cGMP-dependent 3',5'-cyclic phosphodiesterase Inhibitor CP-461... 4 34
Gamma-aminobutyric acid receptor subunit alpha-1 Ligand 1-(9h-... 4 25
Fibroblast growth factor receptor 2 Ligand Interferon Alfa (if... 14 162
Cannabinoid receptor 2 Ligand JWH-167 Family 25 168
Somatostatin receptor type 2 Ligand L-054852 Family 13 88
Carbonic anhydrase 2 Inhibitor N-[2-(1h-indol-5-yl)-butyl]-4-s... 12 70
Substance-K receptor and Substance-P receptor Ligand L-732138 ... 8 147
cGMP-inhibited 3',5'-cyclic phosphodiesterase A and Cytochrome... 9 40
Histone deacetylase 1 and Histone deacetylase 2 Inhibitor N-(4... 4 21
Histone deacetylase 6 Inhibitor N-(quinolin-3-yl)-6-(sulfamoyl... 4 8
Acetylcholinesterase and Cholinesterase Inhibitor Lipocrine Fa... 18 36
Poly [ADP-ribose] polymerase 1 Inhibitor 1,7,8,9-tetrahydro-1,... 19 64
Melanocortin receptor 3 and Melanocortin receptor 4 Ligand C[n... 12 10
Melanocortin receptor Ligand Ac-his-dnal(2)-arg-trp-nh2 Family 112 67
Cholecystokinin receptor type A Ligand VL-0395 Family 12 117
Inosine-5'-monophosphate dehydrogenase 2 Inhibitor 1-methyl-1h... 24 50
Adenosine receptor A1 and Adenosine receptor A3 Ligand VUF-850... 28 47
Transient receptor potential cation channel subfamily V member... 6 23
Cannabinoid receptor 1 and Cannabinoid receptor 2 Ligand JWH-3... 37 1
Cannabinoid receptor 1 and Cannabinoid receptor 2 Ligand JWH-2... 8 1
D(4) dopamine receptor Ligand ABT-670 Family 4 14
Microsomal triglyceride transfer protein large subunit Inhibit... 5 9
Delta-type opioid receptor Ligand H-poa-ser-gly-phe-leu-thr-oh... 5 12
Cannabinoid receptor 1 Ligand N-phenyl-5,6-dip-tolylpyrazine-2... 11 26
Melanocortin receptor 3 and Melanocortin receptor 4 Ligand C[c... 20 18
C-C chemokine receptor type 5 Ligand GT-1282 Family 21 14
Nitric oxide synthase, inducible and Nitric oxide synthase, br... 4 6
14-alpha sterol demethylase Inhibitor CP-320626 Family 13 76
Poly [ADP-ribose] polymerase 1 Inhibitor 3-ethenylquinoline-8-... 8 4
5-hydroxytryptamine receptor 2C Ligand Cyclo[(6-bromotryptopha... 3 17
Cytochrome P450 11B1, mitochondrial and Aromatase Inhibitor 5-... 4 10
Bifunctional epoxide hydrolase 2 Inhibitor N-(3,3-diphenyl-pro... 6 14
Angiotensin-converting enzyme and Endothelin-converting enzyme... 2 10
Kappa-type opioid receptor and Mu-type opioid receptor Ligand ... 19 108
Mitogen-activated protein kinase 14 Inhibitor N-(4-fluorobenzy... 19 32
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 3 29
Glutamate receptor 1 Ligand Piriqualone Family 8 67
3-oxo-5-alpha-steroid 4-dehydrogenase 1 and 3-oxo-5-alpha-ster... 3 27
Endothelin B receptor Ligand IRL-2500 Family 34 87
Vasopressin V1a receptor and Vasopressin V1b receptor Ligand D... 10 19
Amine oxidase [flavin-containing] A Inhibitor N-benzyl-1h-pyrr... 12 46
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 12 72
Metabotropic glutamate receptor 1 Ligand N-(2-phenylpropyl)qui... 3 1
Vasopressin V2 receptor Ligand YM-35278 Family 33 38
Acetylcholinesterase and Cholinesterase Inhibitor 3-(2-diethyl... 12 160
Histone deacetylase Inhibitor ST-5732 Family 8 6
Bombesin receptor subtype-3 and Gastrin-releasing peptide rece... 42 7
Acetylcholinesterase and Cholinesterase Inhibitor Huprine-tacr... 62 27
Dipeptidyl peptidase 4 inhibitor (1S,3S,5S)-2-[(2S)-2-amino-2-... 3 5
Huntingtin and Glycogen synthase kinase-3 beta inhibitor SB 21... 2 4
Rho-associated protein kinase 2 and cAMP-dependent protein kin... 2 7
Dipeptidyl peptidase 1 inhibitor (2S)-2-amino-N-[(1S)-1-cyano-... 2 14
Histone deacetylase 3 and Histone deacetylase 6 inhibitor Tria... 20 37
Mitogen-activated protein kinase 14 and Mast/stem cell growth ... 4 4
Cholecystokinin receptor type A ligand A-65186 family 2 6
Gonadotropin-releasing hormone receptor ligand 1-(3-azabicyclo... 6 2
Gonadotropin-releasing hormone receptor ligand 5-[2-[[(2S)-2-[... 7 58
Cholecystokinin receptor type A and Gastrin/cholecystokinin ty... 17 28
Gastrin/cholecystokinin type B receptor and Cholecystokinin re... 14 8
Growth hormone secretagogue receptor type 1 ligand 2-amino-N-[... 1 0
Survival motor neuron protein and Beta-lactamase inhibitor CHE... 1 0
Substance-P receptor ligand N-[(1S,2R)-2-[[(1R)-1-[methyl-(2-p... 2 0
Sodium-dependent serotonin transporter and Sodium-dependent do... 10 2
MAP kinase-activated protein kinase 2 inhibitor CHEMBL1233942 ... 6 0
Prothrombin inhibitor (2S)-N-[(6-carbamimidoylpyridin-3-yl)met... 2 14
MAP kinase-activated protein kinase 2 and Mitogen-activated pr... 5 2
Histamine H3 receptor ligand AGN-PC-04YWRD family 5 13
Renin inhibitor [(2S,4S,5S,7R)-4-amino-8-(butylamino)-5-hydrox... 3 1
Cellular tumor antigen p53 inhibitor CHEMBL1418224 family 1 62
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 4 0
3-oxo-5-alpha-steroid 4-dehydrogenase 1 and 3-oxo-5-alpha-ster... 1 1
Calpain-1 catalytic subunit and Cathepsin B inhibitor AGN-PC-0... 5 2
Cellular tumor antigen p53 and Beta-lactamase inhibitor CHEMBL... 1 36
Survival motor neuron protein and Nonstructural protein 1 inhi... 1 18
Prelamin-A/C and Tyrosyl-DNA phosphodiesterase 1 inhibitor nif... 1 0
Thyroid hormone receptor beta and Microtubule-associated prote... 1 8
Disintegrin and metalloproteinase domain-containing protein 17... 5 9
Disintegrin and metalloproteinase domain-containing protein 17... 2 0
Cellular tumor antigen p53 and Microtubule-associated protein ... 1 3
Disintegrin and metalloproteinase domain-containing protein 17... 3 3
Survival motor neuron protein and Menin inhibitor CHEMBL151109... 1 11
Peptide deformylase inhibitor (2R)-N-[(2S)-3,3-dimethyl-1-oxo-... 2 1
Cannabinoid receptor 2 ligand [(4R,4aS,8aR)-4-hydroxy-4-phenyl... 2 41
Prothrombin and Trypsin-1 inhibitor 2-[6-methyl-2-oxo-3-(2-pyr... 4 2
Dipeptidyl peptidase 4 inhibitor (2S)-1-[2-[5-(aminomethyl)-2-... 4 4
Glycogen synthase kinase-3 beta and Tyrosine-protein kinase JA... 1 0
Acetylcholinesterase inhibitor CHEMBL1651131 family 6 9
Translocator protein inhibitor AGN-PC-08WI0V family 1 0
Bifunctional epoxide hydrolase 2 inhibitor AGN-PC-04SK7R family 3 3
Substance-K receptor ligand N-[1-[[(2S)-1-[[1-(oxan-4-ylmethyl... 3 0
Substance-K receptor ligand N-[1-[[(2R)-5-[4-(oxan-4-ylmethyl)... 2 0
Interstitial collagenase and Matrilysin inhibitor (2S,3R)-N,2-... 3 1
Substance-P receptor ligand N-[(2S)-5-[3,5-bis(trifluoromethyl... 4 6
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 3 2
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 18 3
Substance-P receptor and Neuromedin-K receptor ligand SureCN88... 4 14
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 1 0
Histamine H3 receptor ligand SureCN1857507 family 1 4
Histone deacetylase and Histone deacetylase 3 inhibitor (3S,6R... 2 2
Renin and Potassium voltage-gated channel subfamily H member 2... 9 2
Renin inhibitor [2-[(3-fluoro-2-methylphenyl)methyl]-6-methyl-... 2 1
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 2 1
Poly [ADP-ribose] polymerase 1 inhibitor CHEMBL186461 family 2 4
Collagenase 3 and 72 kDa type IV collagenase inhibitor (2R)-N-... 3 2
Ribosomal protein S6 kinase alpha-3 inhibitor 1-oxo-N-[1-(pyri... 5 11
MAP kinase-activated protein kinase 2 inhibitor 4-fluoro-N-[4-... 25 1
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 5 4
Delta-type opioid receptor and Potassium voltage-gated channel... 2 0
Cannabinoid receptor 1 ligand (2-cyclopentyl-5-prop-2-enyl-3,4... 3 8
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand AGN-P... 14 1
Melanin-concentrating hormone receptor 1 and Melanin-concentra... 3 1
Neuropeptide Y receptor type 5 ligand 2-indol-1-yl-N-[4-[(prop... 7 6
Histone deacetylase 6 and Histone deacetylase 1 inhibitor 4-[(... 3 5
Substance-P receptor ligand [3,5-bis(trifluoromethyl)phenyl]-[... 17 1
Cannabinoid receptor 1 ligand N-[2-(cyclopropylamino)-2-oxoeth... 5 5
Hematopoietic prostaglandin D synthase inhibitor 4-(3-methylis... 1 7
High affinity nerve growth factor receptor and BDNF/NT-3 growt... 4 3
Oxytocin receptor ligand (3R,6R)-3-(2,3-dihydro-1H-inden-2-yl)... 20 2
Egl nine homolog 1 inhibitor 1'-[(3-methylpyridin-2-yl)methyl]... 6 4
Dipeptidyl peptidase 4 inhibitor [(2S,4S)-4-(4-quinolin-4-ylpi... 5 8
Cathepsin K and Cathepsin S inhibitor (2S)-N-(cyanomethyl)-4-m... 1 0
cAMP-specific 3',5'-cyclic phosphodiesterase 4B and cAMP-speci... 2 3
Melanin-concentrating hormone receptor 1 ligand N-[(3S)-1-[[(3... 2 0
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 8 inhibitor Di... 2 3
Probable G-protein coupled receptor 142 ligand (2S)-N-(2-oxo-5... 2 1
Glutamate receptor ionotropic, NMDA 2B ligand N-[3-[2-(4-benzy... 2 0
Dual specificity protein kinase CLK4 and Mitogen-activated pro... 1 1
RAC-beta serine/threonine-protein kinase and 3-phosphoinositid... 11 4
Cannabinoid receptor 1 ligand N-(cyclobutylmethyl)-3-[[4-(meth... 1 1
Cannabinoid receptor 1 and Cytochrome P450 3A4 ligand N-(oxan-... 2 0
Coagulation factor X inhibitor 3-chloro-N-[(1S,2S)-2-[[4-(2-ox... 22 3
Gonadotropin-releasing hormone receptor ligand 1-adamantyl-[2-... 3 1
Fatty-acid amide hydrolase 1 inhibitor 1-[3-[4-(6-phenylhexyl)... 1 0
Seprase and Prolyl endopeptidase inhibitor [(2R)-1-[(2R)-2-[(2... 4 2
Neutrophil elastase inhibitor N-[(2S)-3-methyl-1-oxo-1-[(2S)-2... 4 4
Leucine-rich repeat serine/threonine-protein kinase 2 inhibito... 2 3
Disintegrin and metalloproteinase domain-containing protein 17... 7 9
Disintegrin and metalloproteinase domain-containing protein 17... 13 3
Dipeptidyl peptidase 4 inhibitor 2-[(3R)-3-aminopiperidin-1-yl... 3 4
Motilin receptor ligand SureCN2768052 family 3 0
Tankyrase-1 inhibitor N-[4-[(4S)-5,5-dimethyl-2-oxo-4-phenyl-1... 3 2
Seprase and Prolyl endopeptidase inhibitor 7-chloro-N-[2-[(2S)... 3 3
Gonadotropin-releasing hormone receptor ligand SureCN7899418 f... 12 4
Acetyl-CoA carboxylase 2 and Acetyl-CoA carboxylase 1 inhibito... 3 0
Nicotinamide phosphoribosyltransferase inhibitor N-[[4-(3-fluo... 6 4
Metabotropic glutamate receptor 5 ligand AGN-PC-09SALK family 2 15
3-oxo-5-alpha-steroid 4-dehydrogenase 2 and 3-oxo-5-alpha-ster... 2 1
Phospholipase D1 and Phospholipase D2 inhibitor SureCN10311349... 2 14
Histone deacetylase 1 inhibitor (2S)-N'-hydroxy-2-(pyridine-2-... 3 0
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 8 inhibitor (2... 2 2
Stromelysin-1 and 72 kDa type IV collagenase inhibitor (2S,4R)... 2 2
Cholinesterase and Acetylcholinesterase inhibitor [2,2-dimethy... 2 0
Substance-P receptor ligand AGN-PC-004REJ family 3 0
Substance-P receptor ligand (4R)-N-[(2R)-1-[benzyl(methyl)amin... 8 5
Bombesin receptor subtype-3 ligand SureCN13887096 family 3 1
Platelet-activating factor receptor ligand (1-ethylindol-3-yl)... 17 13
Platelet-activating factor receptor ligand N,N-diethyl-3-[(4R)... 11 0
Integrin beta-3 and Integrin alpha-V inhibitor 2-[(2S)-4-methy... 2 0
Platelet-activating factor receptor ligand (4R)-N-(3-benzoylph... 2 1
Endothelin-1 receptor and Endothelin B receptor ligand 2-[[(2R... 5 3
Stromelysin-3 and Neutrophil collagenase inhibitor AGN-PC-074N... 3 1
Substance-P receptor and Substance-K receptor ligand N-methyl-... 2 2
Histone deacetylase 1 inhibitor AGN-PC-0456JP family 1 0
Somatostatin receptor type 2 ligand tert-butyl (2S)-6-amino-2-... 3 1
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-2-[(1-benz... 2 1
Growth factor receptor-bound protein 2 ligand [4-[(2S)-2-aceta... 5 2
KiSS-1 receptor ligand SureCN5132924 family 2 4
72 kDa type IV collagenase and Interstitial collagenase inhibi... 1 1
Sodium-dependent serotonin transporter and D(2) dopamine recep... 1 0
5-hydroxytryptamine receptor 3E and 5-hydroxytryptamine recept... 1 1
Dipeptidyl peptidase 4 inhibitor SureCN5777667 family 1 4
P2Y purinoceptor 12 inhibitor (4S)-4-[[4-[4-[3-(dimethylamino)... 106 49
5-hydroxytryptamine receptor 7 ligand AGN-PC-00PFK0 family 1 0
Interstitial collagenase and Stromelysin-1 inhibitor CHEMBL887... 1 0
Metabotropic glutamate receptor 5 ligand 3-methyl-1-[2-[3-(tri... 3 1
Interstitial collagenase and Matrix metalloproteinase-9 inhibi... 1 5
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 2 0
Protein-glutamine gamma-glutamyltransferase 2 inhibitor SureCN... 2 2
Tyrosine-protein kinase JAK3 inhibitor (3Z)-5-pyridin-3-yl-3-(... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00359532 CHEMBL144267 Bioactive (2R,3S)-N-[(2S)-3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl]-N'-hydroxy-2-(2-methylpropyl)-3-(quinoline-6-carbonylamino)butanediamide
CFAMM00359531 CHEMBL147051 Bioactive (2S,3S)-N-[(2S)-3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl]-N'-hydroxy-2-(2-methylpropyl)-3-(quinolin-8-ylmethylsulfanyl)butanediamide
CFAMM00359534 CHEMBL144568 Bioactive (2R,3S)-N-[(2S)-3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl]-N'-hydroxy-2-(2-methylpropyl)-3-(quinoline-8-carbonylamino)butanediamide
CFAMM00359533 CHEMBL359217 Bioactive (2R,3S)-N-[(2S)-3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl]-N'-hydroxy-2-(2-methylpropyl)-3-(quinolin-2-ylmethylamino)butanediamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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