CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM4857
Family Name Disintegrin and metalloproteinase domain-containing protein 17 and Interstitial collagenase inhibitor (2R,3S)-3-[benzenesulfonyl(methyl)amino]-N-[(2S)-3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl]-N'-hydroxy-2-(2-methylpropyl)butanediamide family
No. of Seeds 6 No. of Other Members 5
Family Centroid CFAMM00359552 Functional Category Bioactive
Superfamily Disintegrin and metalloproteinase domain-containing protein 17 Binder Superfamily 8
Class Class 4157

Cousin Family NamesSeedsMembers
Cathepsin K Inhibitor Odanacatib Family 33 84
72 kDa type IV collagenase Inhibitor Batimastat Family 6 52
72 kDa type IV collagenase and Matrix metalloproteinase-9 Inhi... 40 87
Neuromedin-K receptor Ligand PD-157672 Family 9 37
Carbonic anhydrase 1 and Carbonic anhydrase 2 Inhibitor 2-valp... 8 5
Cathepsin B and Cathepsin S Inhibitor Ac-hphe-leu-ala-leuvsme ... 17 51
Disintegrin and metalloproteinase domain-containing protein 17... 7 39
Carbonic anhydrase 1 and Carbonic anhydrase 2 Inhibitor 4-(2-p... 6 19
Calpain Inhibitor SJA-6017 Family 2 12
72 kDa type IV collagenase and Matrix metalloproteinase-9 inhi... 2 6
Cathepsin L1 and Cathepsin B inhibitor (2S)-3-methyl-N-[(2S)-4... 7 24
Pol polyprotein inhibitor Lysine Sulfonamide 11c family 3 73
Neutrophil collagenase and Stromelysin-1 inhibitor AGN-PC-044L... 6 7
Matrix metalloproteinase-9 and 72 kDa type IV collagenase inhi... 6 1
Disintegrin and metalloproteinase domain-containing protein 17... 2 0
Disintegrin and metalloproteinase domain-containing protein 17... 2 0
Matrix metalloproteinase-9 and Stromelysin-1 inhibitor N-[(2S)... 1 0
Carbonic anhydrase 12 and Carbonic anhydrase 2 inhibitor AGN-P... 5 0
Collagenase 3 and 72 kDa type IV collagenase inhibitor (2R)-N-... 10 1
Bifunctional epoxide hydrolase 2 inhibitor N-cycloheptyl-1-(2,... 7 8
Bifunctional epoxide hydrolase 2 inhibitor N-cycloheptyl-1-(2,... 1 0
Neutrophil collagenase and Collagenase 3 inhibitor (2R)-2-[2-a... 1 0
72 kDa type IV collagenase and Stromelysin-1 inhibitor (2R)-N-... 7 1
Neutrophil elastase inhibitor 1-[(2S)-3-methyl-2-(naphthalen-2... 3 1
Disintegrin and metalloproteinase domain-containing protein 17... 2 0
72 kDa type IV collagenase and Stromelysin-1 inhibitor (3R)-3-... 3 2
Growth hormone secretagogue receptor type 1 ligand [(3S)-3-ami... 2 6
Neutrophil collagenase and Interstitial collagenase inhibitor ... 1 0
Endothelin-converting enzyme 1 and Angiotensin-converting enzy... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00359549 CHEMBL277658 Bioactive (2S,11S,12R)-11-N-hydroxy-2-N-methyl-12-(2-methylpropyl)-13-oxo-7-(2,4,6-trimethylphenyl)sulfonyl-1,7-diazacyclotridecane-2,11-dicarboxamide
CFAMM00359548 CHEMBL145069 Bioactive (2R,3S)-N-[(2S)-3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl]-N'-hydroxy-2-(2-methylpropyl)-3-(naphthalen-1-ylsulfonylamino)butanediamide
CFAMM00359552 CHEMBL344060 Bioactive (2R,3S)-3-[benzenesulfonyl(methyl)amino]-N-[(2S)-3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl]-N'-hydroxy-2-(2-methylpropyl)butanediamide
CFAMM00359558 CHEMBL356259 Bioactive (2R,3S)-3-(benzenesulfonamido)-N-[(2S)-3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl]-N'-hydroxy-2-(2-methylpropyl)butanediamide
CFAMM00359551 CHEMBL144283 Bioactive (2R,3S)-N-[(2S)-3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl]-N'-hydroxy-2-(2-methylpropyl)-3-(naphthalen-2-ylsulfonylamino)butanediamide
CFAMM00359557 CHEMBL24761 Bioactive (2S,11S,12R)-7-(benzenesulfonyl)-11-N-hydroxy-2-N-methyl-12-(2-methylpropyl)-13-oxo-1,7-diazacyclotridecane-2,11-dicarboxamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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