CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM4878
Family Name Sigma non-opioid intracellular receptor 1 ligand 2-(2-nitrophenyl)-1-[4-(3-phenylpropyl)piperazin-1-yl]ethanone family
No. of Seeds 2 No. of Other Members 5
Family Centroid CFAMM00359697 Functional Category Bioactive
Superfamily Prelamin-A/C and D(4) dopamine receptor Binder Superfamily
Class Class 1597

Cousin Family NamesSeedsMembers
D(2) dopamine receptor and D(3) dopamine receptor ligand indol... 4 123
Mu-type opioid receptor Ligand Fentanyl Family 9 647
Sodium channel protein type 5 subunit alpha Ligand Procainamid... 7 291
Nitric oxide synthase, brain Inhibitor NXN-188 Family 1 7
Motilin receptor Ligand GSK962040 Family 30 457
Serine/threonine-protein kinase mTOR Inhibitor CC-223 Family 12 135
Pan-DAC Inhibitor AR-42 Family 21 153
Dual specificity mitogen-activated protein kinase kinase Inhib... 7 69
Potassium voltage-gated channel subfamily A member 5 Ligand S-... 34 206
Vasopressin-neurophysin 2-copeptin Inhibitor Niravoline Family 7 45
Vasopressin V1a receptor and Vasopressin V2 receptor Ligand OP... 12 94
Beta-secretase 1 Inhibitor N-(1-benzylpiperidin-4-yl)-4-sulfan... 7 62
5-hydroxytryptamine receptor 1A and Alpha-1A adrenergic recept... 19 88
Alpha-2A adrenergic receptor and Alpha-2B adrenergic receptor ... 19 32
3-oxo-5-alpha-steroid 4-dehydrogenase 1 Inhibitor 1-methyl-5-(... 6 17
Aromatase Inhibitor 3-(4-amino-phenyl)-1-methyl-pyrrolidine-2,... 4 8
Cannabinoid receptor 1 Ligand 1,3,5-triphenylimidazolidine-2,4... 2 17
Voltage-dependent T-type calcium channel subunit alpha-1H Liga... 3 26
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 14 110
Histamine H3 receptor Ligand (r)-1-(4-nitrophenethyl)-2-methyl... 16 38
Leukotriene A-4 hydrolase Inhibitor N5-[4-benzylphenyl]-l-glut... 2 1
Cannabinoid receptor 2 Ligand N1-(4-bromophenyl)-n2,n2-dipenty... 4 21
5-hydroxytryptamine receptor 7 Ligand UCM-5600 Family 15 46
Enoyl-[acyl-carrier-protein] reductase [NADH] Inhibitor N-(4-(... 2 17
Mitogen-activated protein kinase 14 Inhibitor Dihydro-quinolin... 3 14
Sodium-dependent dopamine transporter and Sodium-dependent nor... 2 7
Bifunctional epoxide hydrolase 2 Inhibitor 1-phenyl-3-(1-propi... 22 183
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 15 129
5-hydroxytryptamine receptor 2A Ligand N-(1-(4-nitrobenzyl)pip... 4 6
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 53 289
D(4) dopamine receptor ligand AGN-PC-074VC9 family 2 3
D(4) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 2 1
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 7 5
Acetylcholinesterase inhibitor 2-[2-(1-benzylpiperidin-4-yl)et... 2 9
Thyroid hormone receptor beta and DNA-(apurinic or apyrimidini... 1 0
C-C chemokine receptor type 5 ligand N-[1-[(3R)-4-[benzenesulf... 3 2
5-hydroxytryptamine receptor 1A ligand SureCN4244417 family 10 1
Baculoviral IAP repeat-containing protein 2 and E3 ubiquitin-p... 2 1
D(2) dopamine receptor and Potassium voltage-gated channel sub... 1 1
Nociceptin receptor and Mu-type opioid receptor ligand N,N-dim... 5 4
Sigma non-opioid intracellular receptor 1 ligand 1-[(3-nitroph... 4 2
Mu-type opioid receptor ligand CHEMBL2310836 family 4 4
Cannabinoid receptor 2 ligand 1-adamantyl-(5-fluoro-2,3-dihydr... 4 7
Nociceptin receptor and Mu-type opioid receptor ligand AGN-PC-... 4 6
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 5 1
Somatostatin receptor type 1 and Somatostatin receptor type 2 ... 2 11
5-hydroxytryptamine receptor 7 ligand 3-ethyl-3-[4-[4-(4-fluor... 3 1
5-hydroxytryptamine receptor 7 ligand 2-[4-[4-(2-oxo-1,3,4,5-t... 1 0
Kappa-type opioid receptor ligand 1-[4-acetyl-2-[[(3S)-3-hydro... 1 0
Chitin synthase 1 inhibitor AC1O53V7 family 9 0
Vascular endothelial growth factor receptor 2 ligand SureCN578... 1 2
Kappa-type opioid receptor ligand N-[(2S)-1-(2,5-dihydropyrrol... 1 1
Kappa-type opioid receptor ligand 2-[2-[bis(methylsulfonyl)ami... 2 0
Kappa-type opioid receptor and Delta-type opioid receptor liga... 3 1
Histone deacetylase 1 inhibitor AGN-PC-07ZGOT family 2 1
Substance-P receptor ligand 3-[bis(4-fluorophenyl)methyl]-1-[(... 1 0
Interstitial collagenase and Matrix metalloproteinase-9 inhibi... 2 2
Transcriptional activator protein LuxR and Transcriptional act... 4 4


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00359701 CHEMBL311622 Bioactive AGN-PC-00G9A8
CFAMM00359697 CHEMBL144469 Bioactive 2-(2-nitrophenyl)-1-[4-(3-phenylpropyl)piperazin-1-yl]ethanone

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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