CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM493
Family Name Neuromedin-K receptor and Substance-P receptor ligand AGN-PC-07ZFZM family
No. of Seeds 18 No. of Other Members 0
Family Centroid CFAMM00312178 Functional Category Bioactive
Superfamily Substance-P receptor and Neuromedin-K receptor Binder Superfamily
Class Class 1006

Cousin Family NamesSeedsMembers
Calcitonin gene-related peptide type 1 receptor Ligand Telcage... 25 124
Class II cytokine receptor Ligand IL-10 Family 7 45
Calcitonin gene-related peptide type 1 receptor Ligand Isomer ... 30 31
Mitogen-activated protein kinase 14 Inhibitor N-(4-fluorobenzy... 19 32
Mitogen-activated protein kinase 1 and Cytochrome P450 3A4 inh... 1 0
Substance-P receptor and Neuromedin-K receptor ligand 2-[3,5-b... 7 0
Mast/stem cell growth factor receptor Kit and Mitogen-activate... 4 2
Substance-P receptor ligand 2-[3,5-bis(trifluoromethyl)phenyl]... 3 1
Substance-P receptor and Neuromedin-K receptor ligand 2-[3,5-b... 6 0
Substance-P receptor ligand Netupitant family 5 2
Melanin-concentrating hormone receptor 1 ligand 6-(4-chlorophe... 8 1
Succinate receptor 1 ligand N-[[4-(3-methylphenyl)phenyl]methy... 2 14
Transient receptor potential cation channel subfamily V member... 57 4
Substance-P receptor and Neuromedin-K receptor ligand 2-[3,5-b... 4 0
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor SureC... 6 0
Orexin receptor type 2 and Orexin receptor type 1 ligand SureC... 2 0
Transient receptor potential cation channel subfamily V member... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00312168 CHEMBL1084435 Bioactive 2-[3,5-bis(trifluoromethyl)phenyl]-N-[4-(2-chlorophenyl)-6-[(2R)-2-(hydroxymethyl)piperidin-1-yl]pyridin-3-yl]-N,2-dimethylpropanamide
CFAMM00312161 CHEMBL1084438 Bioactive 2-[3,5-bis(trifluoromethyl)phenyl]-N-[4-(2-chlorophenyl)-6-[(2S,4R)-4-methoxy-2-(methoxymethyl)pyrrolidin-1-yl]pyridin-3-yl]-N,2-dimethylpropanamide
CFAMM00312174 CHEMBL1083051 Bioactive AGN-PC-07ZFZN
CFAMM00312167 CHEMBL1084434 Bioactive 2-[3,5-bis(trifluoromethyl)phenyl]-N-[4-(2-chlorophenyl)-6-[(2S)-2-(hydroxymethyl)piperidin-1-yl]pyridin-3-yl]-N,2-dimethylpropanamide
CFAMM00312173 CHEMBL1082735 Bioactive AGN-PC-009P31
CFAMM00312166 CHEMBL1084437 Bioactive 2-[3,5-bis(trifluoromethyl)phenyl]-N-[4-(2-chlorophenyl)-6-[(2S,4R)-4-hydroxy-2-(hydroxymethyl)pyrrolidin-1-yl]pyridin-3-yl]-N,2-dimethylpropanamide
CFAMM00312172 CHEMBL1082737 Bioactive AGN-PC-072RQP
CFAMM00312165 CHEMBL1084436 Bioactive 2-[3,5-bis(trifluoromethyl)phenyl]-N-[4-(2-chlorophenyl)-6-[(2S,4S)-4-hydroxy-2-(hydroxymethyl)pyrrolidin-1-yl]pyridin-3-yl]-N,2-dimethylpropanamide
CFAMM00312178 CHEMBL1084165 Bioactive AGN-PC-07ZFZM
CFAMM00312171 CHEMBL1084523 Bioactive 2-[3,5-bis(trifluoromethyl)phenyl]-N-[4-(2-chlorophenyl)-6-[(2S)-2-(hydroxymethyl)pyrrolidin-1-yl]pyridin-3-yl]-N,2-dimethylpropanamide
CFAMM00312164 CHEMBL1084771 Bioactive 2-[3,5-bis(trifluoromethyl)phenyl]-N-[4-(2-chlorophenyl)-6-[(3R)-3-hydroxypyrrolidin-1-yl]pyridin-3-yl]-N,2-dimethylpropanamide
CFAMM00312177 CHEMBL1082415 Bioactive AGN-PC-00685A
CFAMM00312170 CHEMBL1084522 Bioactive 2-[3,5-bis(trifluoromethyl)phenyl]-N-[4-(2-chlorophenyl)-6-[(3S)-3-hydroxypyrrolidin-1-yl]pyridin-3-yl]-N,2-dimethylpropanamide
CFAMM00312163 CHEMBL1086003 Bioactive 2-[3,5-bis(trifluoromethyl)phenyl]-N-[4-(2-chlorophenyl)-6-(2-hydroxyethylamino)pyridin-3-yl]-N,2-dimethylpropanamide
CFAMM00312176 CHEMBL1086004 Bioactive AGN-PC-07ZFU5
CFAMM00312169 CHEMBL1084525 Bioactive AGN-PC-007ET9
CFAMM00312162 CHEMBL1084439 Bioactive 2-[3,5-bis(trifluoromethyl)phenyl]-N-[4-(2-chlorophenyl)-6-[(2R,3S)-3-hydroxy-2-(hydroxymethyl)pyrrolidin-1-yl]pyridin-3-yl]-N,2-dimethylpropanamide
CFAMM00312175 CHEMBL1083052 Bioactive 2-[3,5-bis(trifluoromethyl)phenyl]-N-[4-(2-chlorophenyl)-6-[(2R)-2-(hydroxymethyl)pyrrolidin-1-yl]pyridin-3-yl]-N,2-dimethylpropanamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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