CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM4952
Family Name Integrin beta-3 and Integrin alpha-V inhibitor (3S)-3-[[2-[6-methyl-2-oxo-3-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-ylmethylamino)pyrazin-1-yl]acetyl]amino]-3-pyridin-3-ylpropanoic acid family
No. of Seeds 13 No. of Other Members 12
Family Centroid CFAMM00360239 Functional Category Bioactive
Superfamily Integrin beta-3 and Integrin alpha-V Binder Superfamily 12
Class Class 639

Cousin Family NamesSeedsMembers
Reverse transcriptase Inhibitor Nevirapine Family 23 640
Peptide deformylase, mitochondrial inhibitor folic acid analog... 59 98
Thromboxane A2 receptor Ligand Bibv 308 Family 14 40
Mast/stem cell growth factor receptor Kit and Vascular endothe... 4 47
XL-888 family 16 85
Integrin beta-3 Inhibitor Elarofiban Family 28 45
Integrin alpha-V and Integrin beta-3 Inhibitor SB-223245 Family 27 36
D(2) dopamine receptor and D(3) dopamine receptor Ligand Azape... 7 102
Nitric oxide synthase, inducible and Nitric oxide synthase, br... 4 6
Integrin beta-3 and Integrin alpha-V inhibitor AGN-PC-03RR5Q f... 3 2
Integrin beta-3 and Integrin alpha-V inhibitor methyl (3S)-3-(... 12 13
Integrin beta-3 and Integrin alpha-V inhibitor SureCN547914 fa... 8 32
Integrin alpha-V and Integrin beta-5 inhibitor SureCN6563167 f... 2 10
Integrin beta-3 and Integrin alpha-V inhibitor (3S)-3-(4-ethox... 4 5
Integrin beta-3 and Integrin alpha-V inhibitor SureCN3888804 f... 11 13
Integrin beta-3 and Integrin alpha-V inhibitor (3R)-3-quinolin... 6 8
Prothrombin and Cationic trypsin inhibitor tert-butyl N-[(2R)-... 4 3
Integrin beta-3 and Integrin alpha-V inhibitor (2S)-3-[[4-[2-(... 3 3
Serine/threonine-protein kinase Chk1 inhibitor SureCN3070314 f... 16 32
Carboxypeptidase B2 and Carboxypeptidase B inhibitor 3-(6-amin... 5 10
Integrin beta-3 and Integrin alpha-V inhibitor SureCN6359092 f... 9 5
Integrin beta-3 and Integrin alpha-IIb inhibitor 3-[[1-(3-pipe... 3 0
Prostaglandin D2 receptor 2 ligand SureCN2215286 family 7 5
C-C chemokine receptor type 2 and Potassium voltage-gated chan... 3 1
Renin inhibitor (3R)-4-[[(2S,5S)-1-cyclohexyl-3-hydroxy-6-meth... 3 4
Integrin beta-3 and Integrin alpha-V inhibitor (3S,7S)-7-hydro... 5 1
Integrin beta-3 and Integrin alpha-V inhibitor (2S)-2-[[(1R,4S... 3 0
B1 bradykinin receptor ligand AGN-PC-005XAO family 3 17
Integrin beta-3 and Integrin alpha-V inhibitor (2S)-2-(benzene... 3 2
Integrin beta-3 and Integrin alpha-V inhibitor (2S)-3-[5-methy... 4 5
Integrin beta-3 and Integrin alpha-V inhibitor SureCN2924568 f... 1 0
Integrin beta-3 and Integrin alpha-V inhibitor SureCN8335217 f... 2 1
Integrin beta-3 and Integrin alpha-V inhibitor AGN-PC-00BBPN f... 2 3
Integrin beta-3 and Integrin alpha-V inhibitor SureCN2833591 f... 4 6
Integrin beta-1 and Integrin alpha-5 inhibitor (2S)-2-[(2,6-di... 6 5
B1 bradykinin receptor ligand methyl 2-fluoro-6-[3-fluoro-4-[[... 22 11
Integrin beta-3 and Integrin alpha-V inhibitor SureCN6220269 f... 1 0
Aurora kinase A and Cyclin-dependent kinase 4 inhibitor 2-[3-[... 1 0
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor AGN-P... 7 6
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor SureC... 6 0
Integrin beta-3 and Integrin alpha-V inhibitor AGN-PC-00IW9E f... 3 0
Integrin alpha-V and Integrin beta-6 inhibitor 3-[[2-[4-[(4-me... 4 3
Integrin alpha-V and Integrin beta-6 inhibitor SureCN12259087 ... 3 4
Integrin beta-3 and Integrin alpha-V inhibitor (3S)-3-(3-fluor... 10 0
Integrin beta-3 and Integrin alpha-V inhibitor AGN-PC-074ASN f... 2 0
Integrin beta-3 and Integrin alpha-IIb inhibitor (3S)-3-[[3-(2... 4 2
Integrin beta-3 and Integrin alpha-V inhibitor AGN-PC-074ASZ f... 5 0
Integrin beta-3 and Integrin alpha-V inhibitor (3S)-3-[[2-[4-(... 3 0
Integrin beta-3 and Integrin alpha-IIb inhibitor (3S)-3-[[2-[(... 3 1
Integrin beta-1 and Integrin alpha-5 inhibitor 2-[(2,6-dimethy... 9 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00360258 CHEMBL298706 Bioactive SureCN7445494
CFAMM00360237 CHEMBL416669 Bioactive (3S)-3-[[2-[2-oxo-3-[2-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)ethyl]piperidin-1-yl]acetyl]amino]-3-pyridin-3-ylpropanoic acid
CFAMM00360250 CHEMBL53822 Bioactive (3S)-3-pyridin-3-yl-3-[[2-[4-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)butanoylamino]acetyl]amino]propanoic acid
CFAMM00360243 CHEMBL300008 Bioactive (3S)-3-[[2-[(3S)-2-oxo-3-[2-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)ethyl]pyrrolidin-1-yl]acetyl]amino]-3-pyridin-3-ylpropanoic acid
CFAMM00360236 CHEMBL329081 Bioactive (3S)-3-[[2-[(3R)-2-oxo-3-[2-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)ethyl]pyrrolidin-1-yl]acetyl]amino]-3-pyridin-3-ylpropanoic acid
CFAMM00360249 CHEMBL51152 Bioactive (3S)-3-[[2-[6-cyclopropyl-2-oxo-3-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-ylmethylamino)pyrazin-1-yl]acetyl]amino]-3-pyridin-3-ylpropanoic acid
CFAMM00360256 CHEMBL51490 Bioactive (3S)-3-[[2-[2-oxo-6-propyl-3-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-ylmethylamino)pyridin-1-yl]acetyl]amino]-3-pyridin-3-ylpropanoic acid
CFAMM00360248 CHEMBL300494 Bioactive (3S)-3-[[2-[2-oxo-3-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-ylmethylamino)pyridin-1-yl]acetyl]amino]-3-pyridin-3-ylpropanoic acid
CFAMM00360255 CHEMBL145095 Bioactive SureCN6435408
CFAMM00360234 CHEMBL54122 Bioactive (3S)-3-[[2-[6-cyclopropyl-2-oxo-3-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-ylmethylamino)pyridin-1-yl]acetyl]amino]-3-pyridin-3-ylpropanoic acid
CFAMM00360233 CHEMBL54148 Bioactive (3S)-3-[[2-[3-chloro-2-cyclopropyl-6-oxo-5-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-ylmethylamino)pyrazin-1-yl]acetyl]amino]-3-pyridin-3-ylpropanoic acid
CFAMM00360239 CHEMBL301392 Bioactive (3S)-3-[[2-[6-methyl-2-oxo-3-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-ylmethylamino)pyrazin-1-yl]acetyl]amino]-3-pyridin-3-ylpropanoic acid
CFAMM00360245 CHEMBL351105 Bioactive SureCN13936149

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27278 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


All rights reserved.

   
 
 
Computer-aided Drug Design
about BIDD |  databases |  software |  teaching |  research |  links

 

Department of Computational Science | National University of Singapore | Blk S17, 3 Science Drive 2, Singapore 117543