CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM5
Family Name Melatonin receptor type 1B and Melatonin receptor type 1A ligand N-[2-(2-ethoxy-6H-isoindolo[2,1-a]indol-11-yl)ethyl]butanamide family
No. of Seeds 3 No. of Other Members 16
Family Centroid CFAMM00305769 Functional Category Bioactive
Superfamily Substance-P receptor and Leukotriene B4 receptor 1 Binder Superfamily
Class Class 2449

Cousin Family NamesSeedsMembers
Beta adrenergic receptor ligand monosubstituted indole derivat... 14 475
Cysteinyl leukotriene receptor 1 Ligand Zafirlukast Family 48 78
DNA Binder Primaquine Family 3 245
Melatonin receptor type 1A Ligand Melatonin Family 20 988
Sodium channel protein type 5 subunit alpha Ligand Dibucaine F... 2 136
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor indole... 28 2712
Cyclooxygenase Inhibitor Indomethacin Family 6 271
Phospholipase A2 Inhibitor Quinacrine Family 13 95
ostatin receptor 5 Ligand Pasireotide Diaspartate Family 11 151
DNA Binder Elliptinium Acetate Family 11 116
Phospholipase A2, membrane associated Inhibitor Varespladib Fa... 37 190
Arachidonate 5-lipoxygenase Inhibitor MK-591 Family 9 161
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 12 197
Apricoxib family 8 77
Indeglitazar family 3 39
Nicotinic acetylcholine receptor alpha2 / alpha3 Ligand Ibogai... 3 21
72 kDa type IV collagenase and Matrix metalloproteinase-9 Inhi... 37 265
Protein kinase C theta type Inhibitor 4-(1h-indol-5-yloxy)-5-s... 21 194
5-hydroxytryptamine receptor 3B and 5-hydroxytryptamine recept... 11 41
von Willebrand factor Inhibitor Auryntricarboxylic Acid (ata) ... 12 81
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 13 22
Platelet-derived growth factor receptor alpha and Platelet-der... 2 9
Inosine-5'-monophosphate dehydrogenase 2 Inhibitor 2-benzyl-6-... 9 80
Integrin beta-3 Inhibitor L-756568 Family 8 59
Oestrogen receptor and Estrogen receptor beta Ligand Pipendoxi... 11 48
Alpha-1A adrenergic receptor Ligand RS-17053 Family 9 6
Cannabinoid receptor 2 Ligand JWH-202 Family 9 172
Vascular endothelial growth factor receptor 1 Ligand Lycogarub... 6 292
D(2) dopamine receptor Ligand SLV-314 Family 19 69
DNA-dependent protein kinase catalytic subunit Inhibitor 8-(1h... 3 85
Oestrogen receptor and Estrogen receptor beta Ligand 4-(3-phen... 5 14
Serine/threonine-protein kinase Chk1 Inhibitor A-432411 Family 4 70
Inosine-5'-monophosphate dehydrogenase 2 Inhibitor 3-(furan-3-... 3 44
Platelet-derived growth factor receptor alpha and Platelet-der... 4 54
RAC-gamma serine/threonine-protein kinase Inhibitor A-443654 F... 67 59
Serine/threonine-protein kinase Chk1 and Wee1-like protein kin... 2 101
Neuromedin-K receptor Ligand 3-methoxy-n',2-diphenylquinoline-... 14 33
5-hydroxytryptamine receptor 2C Ligand N-(6-phenoxypyridin-3-y... 9 69
5-hydroxytryptamine receptor 2A and Amine oxidase [flavin-cont... 4 32
Adenosine receptor A1 and Adenosine receptor A2a Ligand SB-298... 53 320
Cyclin-dependent kinase 2 and G1/S-specific cyclin-E1 Inhibito... 5 1
5-hydroxytryptamine receptor 2A and Alpha-2A adrenergic recept... 4 29
Prostaglandin G/H synthase 2 Inhibitor L-761000 Family 8 44
Arachidonate 5-lipoxygenase Inhibitor TZI-41127 Family 7 34
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 18 72
Metabotropic glutamate receptor 5 Ligand 3-methoxy-5-(1,5-naph... 4 20
Cannabinoid receptor 1 Ligand 1-(2-morpholinoethyl)-1h-indol-3... 8 46
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 7 44
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 17 69
Tyrosine-protein kinase SYK and Low affinity immunoglobulin ep... 1 0
Disintegrin and metalloproteinase domain-containing protein 17... 14 9
Glycogen synthase kinase-3 beta and Protein kinase C alpha typ... 2 30
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 7 11
Vasopressin V1a receptor and Vasopressin V2 receptor ligand (3... 4 41
Disintegrin and metalloproteinase domain-containing protein 17... 2 8
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 7 1
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 2 6
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 14 48
Receptor-type tyrosine-protein kinase FLT3 and Mast/stem cell ... 3 5
Vascular endothelial growth factor receptor 2 ligand indolyl q... 2 1
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand SureC... 8 32
Neuropeptide Y receptor type 1 ligand SureCN7959923 family 1 6
Leukotriene B4 receptor 1 and Leukotriene B4 receptor 2 ligand... 8 21
Leukotriene B4 receptor 1 and Leukotriene B4 receptor 2 ligand... 2 5
Leukotriene B4 receptor 1 and Leukotriene B4 receptor 2 ligand... 4 14
Histamine H3 receptor and Cytochrome P450 2D6 ligand AGN-PC-00... 18 32
Histamine H3 receptor ligand AGN-PC-00BG7Z family 11 49
Histamine H3 receptor ligand (4S)-7-bromo-4-methyl-8-(1-propan... 2 0
D(3) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 10 50
Glutamate receptor ionotropic, NMDA 2D and Glutamate receptor ... 2 21
Melatonin receptor type 1A and Melatonin receptor type 1B liga... 2 5
5-hydroxytryptamine receptor 6 ligand SureCN5502542 family 4 2
Disintegrin and metalloproteinase domain-containing protein 17... 4 1
Melanin-concentrating hormone receptor 1 and Cytochrome P450 3... 8 2
Prelamin-A/C inhibitor 1-[(3,4-dimethoxyphenethyl)amino]-3-(1H... 1 2
Cellular tumor antigen p53 and DNA polymerase beta inhibitor C... 1 15
Disintegrin and metalloproteinase domain-containing protein 17... 2 1
Growth hormone secretagogue receptor type 1 ligand 2-amino-N-[... 3 3
Hypoxia-inducible factor 1-alpha and Lethal factor inhibitor C... 1 1
5-hydroxytryptamine receptor 2C and Cytochrome P450 1A2 ligand... 6 4
Poly [ADP-ribose] polymerase 1 inhibitor SureCN5002485 family 2 11
Prelamin-A/C and Microtubule-associated protein tau inhibitor ... 1 16
D(4) dopamine receptor and D(2) dopamine receptor ligand 1-(2-... 3 3
Neprilysin and Angiotensin-converting enzyme inhibitor (2S)-3-... 8 3
Translocator protein inhibitor N-(4-methoxyphenyl)-N,3-dimethy... 2 2
Coagulation factor X and Anionic trypsin-2 inhibitor AGN-PC-07... 1 1
Cellular tumor antigen p53 and Microtubule-associated protein ... 1 15
Glucagon receptor and Mitogen-activated protein kinase 14 liga... 6 5
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 2 4
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 2 0
D(3) dopamine receptor ligand N-[4-[4-(2,3-dichlorophenyl)pipe... 3 15
Potassium voltage-gated channel subfamily H member 2 and Sodiu... 2 13
Progesterone receptor and Androgen receptor ligand AGN-PC-04QD... 1 0
5-hydroxytryptamine receptor 6 ligand 1-[9-(benzenesulfonyl)-6... 11 2
Cannabinoid receptor 1 ligand 5-cyano-N-(3-hydroxy-2,2-dimethy... 17 4
Melatonin receptor type 1A and Melatonin receptor type 1B liga... 2 0
5-hydroxytryptamine receptor 6 ligand SureCN5498885 family 5 4
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 2 5
Integrin alpha-V and Integrin beta-5 inhibitor SureCN2491273 f... 11 10
Histone deacetylase 3 and Histone deacetylase 9 inhibitor (3S,... 1 16
Prostaglandin D2 receptor and Prostacyclin receptor ligand 2-[... 15 2
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 2 1
Disintegrin and metalloproteinase domain-containing protein 17... 44 12
Histone deacetylase 1 and Potassium voltage-gated channel subf... 1 0
Retinoic acid receptor RXR-alpha ligand (E)-3-[3-(3,5-ditert-b... 5 5
Thyroid hormone receptor alpha and Thyroid hormone receptor be... 2 11
Sodium-dependent serotonin transporter inhibitor SureCN7536104... 6 2
Serine/threonine-protein kinase RIO2 and Serine/threonine-prot... 19 10
Glucagon receptor ligand 3-[[4-[(2S)-2-[5-(trifluoromethoxy)-1... 1 2
Translocator protein inhibitor (4S)-N,N-diethyl-9-(2-fluoranyl... 9 10
Integrase inhibitor (Z)-4-[1-[(4-fluorophenyl)methyl]-5-methox... 1 0
RAC-alpha serine/threonine-protein kinase inhibitor 5-[5-[(2S)... 14 2
Serine/threonine-protein kinase pim-2 and cGMP-dependent prote... 8 1
D(3) dopamine receptor ligand AGN-PC-075Z0O family 2 3
Vascular endothelial growth factor receptor 2 and Vascular end... 2 52
Histone deacetylase 6 and Histone deacetylase 1 inhibitor N-hy... 3 2
Substance-P receptor ligand (3R)-4-[3,5-bis(trifluoromethyl)be... 2 3
Histamine H3 receptor ligand 2-[4-(1-methylpyrrole-2-carbonyl)... 3 4
Substance-P receptor ligand 1-[4-(2-methoxyphenyl)piperazin-1-... 11 12
Disintegrin and metalloproteinase domain-containing protein 17... 16 2
Sodium-dependent serotonin transporter and Alpha-1B adrenergic... 42 20
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand N-(1-... 3 2
Translocator protein inhibitor N-methyl-2-(2-oxo-5-pyridin-4-y... 8 15
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 4 5
Cathepsin K inhibitor (1R,2R)-N-(1-cyanocyclopropyl)-2-(6-meth... 3 0
5-hydroxytryptamine receptor 4 and 5-hydroxytryptamine recepto... 5 14
5-hydroxytryptamine receptor 4 and 5-hydroxytryptamine recepto... 4 4
Acetylcholinesterase and Cholinesterase inhibitor N-[5-[(6-chl... 4 2
Transient receptor potential cation channel subfamily V member... 1 5
Translocator protein inhibitor AGN-PC-07BUUF family 11 2
5-hydroxytryptamine receptor 6 ligand 2-methyl-5-(2-nitropheno... 1 6
Seprase and Prolyl endopeptidase inhibitor N-[2-[(2S)-2-cyanop... 1 3
Estrogen receptor and Estrogen receptor beta ligand N-[(2R)-4-... 7 11
Proto-oncogene tyrosine-protein kinase receptor Ret and Vascul... 5 14
Serine/threonine-protein kinase PLK4 inhibitor (3E)-5-methoxy-... 4 0
Dipeptidyl peptidase 4 and Cytochrome P450 3A4 inhibitor 6-[(3... 1 0
Orexin receptor type 2 and Orexin receptor type 1 ligand 9-(4,... 2 5
D(2) dopamine receptor and D(4) dopamine receptor ligand AGN-P... 1 0
Disintegrin and metalloproteinase domain-containing protein 17... 8 0
Alpha-1D adrenergic receptor and Alpha-1A adrenergic receptor ... 1 1
Disintegrin and metalloproteinase domain-containing protein 17... 1 0
Histone deacetylase 3 and Histone deacetylase 9 inhibitor AGN-... 4 20
Mu-type opioid receptor ligand MITRAGYNINE family 2 8
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 4 0
Cathepsin K inhibitor N-[(2S)-4-methyl-1-[2-[4-(2-methylpropox... 4 0
Sigma non-opioid intracellular receptor 1 ligand 1'-[4-[1-(4-f... 2 0
Cyclin-dependent kinase 4 and G1/S-specific cyclin-D1 inhibito... 6 8
Matrix metalloproteinase-9 and Neutrophil collagenase inhibito... 3 7
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 3 2
Interstitial collagenase and Matrilysin inhibitor (3S,6R,7S)-N... 2 4
Melatonin receptor type 1A and Melatonin receptor type 1B liga... 1 0
5-hydroxytryptamine receptor 6 ligand 1-[9-(2,5-dimethoxypheny... 2 0
Gonadotropin-releasing hormone receptor ligand 2-[2-(4-methoxy... 1 1
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 3 9
D(3) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 2 0
Substance-P receptor ligand AGN-PC-00FIT5 family 3 11
Substance-P receptor ligand AGN-PC-0D60L0 family 2 7
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor CHEMBL4... 6 2
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 23 5
Disintegrin and metalloproteinase domain-containing protein 17... 3 0
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 5 0
Disintegrin and metalloproteinase domain-containing protein 17... 9 0
Melanin-concentrating hormone receptor 1 and Potassium voltage... 2 0
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 6 0
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 2 0
Melatonin receptor type 1A and Melatonin receptor type 1B liga... 2 3
Disintegrin and metalloproteinase domain-containing protein 17... 1 0
Growth factor receptor-bound protein 2 ligand [4-[(2S)-2-aceta... 2 1
Signal transducer and activator of transcription 1-alpha/beta ... 1 36
Amine oxidase [flavin-containing] A and Acetylcholinesterase i... 1 2
Dipeptidyl peptidase 4 inhibitor 2-[3-(aminomethyl)-4-(4-fluor... 3 0
Coagulation factor VII and Tissue factor inhibitor 5-azaindole... 4 3
5-hydroxytryptamine receptor 7 and 5-hydroxytryptamine recepto... 1 1
Acetylcholinesterase and Cholinesterase inhibitor P10358 family 2 0
Glycogen synthase kinase-3 beta and G2/mitotic-specific cyclin... 4 13
Glycogen synthase kinase-3 beta and G2/mitotic-specific cyclin... 3 0
Phospholipase A2, membrane associated inhibitor 2-(1-benzyl-2-... 2 1
Telomerase reverse transcriptase inhibitor N-[9-(4-methoxyanil... 2 0
Peroxisome proliferator-activated receptor gamma and Peroxisom... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00305769 CHEMBL9590 Bioactive N-[2-(2-ethoxy-6H-isoindolo[2,1-a]indol-11-yl)ethyl]butanamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27270 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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