CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM5045
Family Name Alpha-1A adrenergic receptor ligand 6,7-dimethoxy-2-[4-[(5-oxido-4-phenyl-1,2,5-oxadiazol-5-ium-3-yl)sulfonyl]piperazin-1-yl]quinazolin-4-amine family
No. of Seeds 3 No. of Other Members 1
Family Centroid CFAMM00360918 Functional Category Bioactive
Superfamily Nuclear receptor ROR-gamma and Alpha-1A adrenergic receptor Binder Superfamily
Class Class 938

Cousin Family NamesSeedsMembers
Alpha-1D adrenergic receptor Ligand Terazosin Family 28 638
Peptide deformylase, mitochondrial Inhibitor Trimetrexate Family 4 311
Epidermal growth factor receptor Ligand Gefitinib Family 26 600
Vascular endothelial growth factor receptor 2 Ligand Cediranib... 8 38
Tyrosine kinase Inhibitor PKI166 Family 17 198
Angiopoietin-1 receptor and Tyrosine-protein kinase Lck Inhibi... 3 64
Epidermal growth factor receptor Ligand 4-(5-bromoindole-3-yl)... 6 15
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 17 49
Sodium channel protein type 5 subunit alpha Ligand Enecadin Fa... 1 11
Angiopoietin-1 receptor and Aurora kinase B ligand SureCN97387... 4 1
3-phosphoinositide-dependent protein kinase 1 and Ribosomal pr... 10 4
Tyrosine-protein kinase Lck inhibitor AGN-PC-073GX8 family 12 1
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor SureCN6... 8 12
DNA-(apurinic or apyrimidinic site) lyase and Retinal dehydrog... 1 3
Dihydrofolate reductase and Bifunctional dihydrofolate reducta... 3 10
Alpha-1D adrenergic receptor and Alpha-1B adrenergic receptor ... 6 9
Cellular tumor antigen p53 and Lysosomal alpha-glucosidase inh... 1 6
Serine/threonine-protein kinase Chk2 and Serine/threonine-prot... 1 0
Adenosine receptor A1 and Adenosine receptor A3 ligand AGN-PC-... 6 8
Alpha-1D adrenergic receptor and Alpha-1B adrenergic receptor ... 1 0
Tyrosine-protein kinase BTK and Tyrosine-protein kinase Lyn in... 5 7
Macrophage colony-stimulating factor 1 receptor and Ephrin typ... 1 0
Vascular endothelial growth factor receptor 2 ligand AGN-PC-00... 8 1
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 2 0
Histone-lysine N-methyltransferase EHMT2 inhibitor N-(1-cyclop... 1 2
Vascular endothelial growth factor receptor 2 ligand 2-aminobe... 1 0
D(2) dopamine receptor ligand AGN-PC-07C1V6 family 2 3
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 6 1
cGMP-inhibited 3',5'-cyclic phosphodiesterase B and cGMP-inhib... 1 1
Multidrug resistance-associated protein 1 inhibitor SureCN6823... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00360920 CHEMBL147624 Bioactive 2-[4-[[4-(cyclooctatetraenyl)-5-oxido-1,2,5-oxadiazol-5-ium-3-yl]sulfonyl]piperazin-1-yl]-6,7-dimethoxyquinazolin-4-amine
CFAMM00360919 CHEMBL147984 Bioactive 6,7-dimethoxy-2-[4-[(4-phenyl-1,2,5-oxadiazol-3-yl)sulfonyl]piperazin-1-yl]quinazolin-4-amine
CFAMM00360918 CHEMBL145838 Bioactive 6,7-dimethoxy-2-[4-[(5-oxido-4-phenyl-1,2,5-oxadiazol-5-ium-3-yl)sulfonyl]piperazin-1-yl]quinazolin-4-amine

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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