CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM5057
Family Name Sodium-dependent dopamine transporter and Sodium-dependent serotonin transporter inhibitor 3-[(E)-3-[4-(2-benzhydryloxyethyl)piperazin-1-yl]prop-1-enyl]phenol family
No. of Seeds 6 No. of Other Members 0
Family Centroid CFAMM00237360 Functional Category Bioactive
Superfamily DNA-dependent protein kinase catalytic subunit Inhibitor 2-morpholin-4-yl-benzo[h]chromene-4-thione Superfamily
Class Class 166

Cousin Family NamesSeedsMembers
Oestrogen receptor Ligand triphenyl ethylene stilbene derivati... 22 420
Serotonin re-uptake Inhibitor Fluoxetine Family 18 682
Opioid receptor ligand opiate Levorphanol Family 18 537
Alpha adrenergic receptor ligand catecholamine Phenylephrine F... 4 39
Muscarinic acetylcholine receptor M3 Ligand Tolterodine Family 8 171
Alpha adrenergic receptor Ligand Phenoxybenzamine Family 4 63
Histamine H1 receptor Ligand Diphenhydramine Family 5 75
Alpha-1B adrenergic receptor ligand Morpholine derivative Phen... 4 152
Noradrenergic re-uptake Inhibitor Reboxetine Family 26 206
Histamine H1 receptor ligand diphenylpiperidine analog Dipheny... 13 224
Mu-type opioid receptor Ligand Alvimopan Family 32 325
5-hydroxytryptamine receptor 2A Ligand Sarpogrelate Family 2 15
Oestrogen receptor Ligand Lasofoxifene Family 19 152
Nicotinic acetylcholine receptor Ligand Benztropine Mesylate F... 10 20
Noradrenergic re-uptake Inhibitor Desvenalfaxine Succinate Family 2 4
Noradrenergic re-uptake and Opioid receptor Ligand Tapentadol ... 21 79
Muscarinic acetylcholine receptor Ligand Umeclidinium Family 7 50
5-hydroxytryptamine receptor 1A Ligand (s)-uh-301 Family 35 20
Squalene synthase Inhibitor (z)-3-[2-(9h-fluoren-2-yloxy)ethyl... 12 92
Choline kinase alpha Inhibitor Hemicholinium-3 Family 4 0
Fibroblast growth factor receptor Ligand SU5403 Family 8 8
Histamine H3 receptor Ligand UCL-2138 Family 23 172
Adenosine receptor A3 and Mu-type opioid receptor Ligand GBR-1... 80 110
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 7 22
Sodium-dependent dopamine transporter and Sodium-dependent nor... 9 16
Potassium voltage-gated channel subfamily A member 5 Ligand 2-... 3 1
Histamine H3 receptor and Sodium-dependent serotonin transport... 25 28
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 5 11
Sodium-dependent noradrenaline transporter Inhibitor WAY-25680... 4 6
Squalene synthase Inhibitor 3-[7'-(methoxy)-napht-2'-yl]-quinu... 53 30
Glutamate receptor ionotropic, NMDA 2B and Glutamate receptor ... 9 7
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 44 3
Sodium-dependent dopamine transporter and Sodium-dependent nor... 5 2
Sodium-dependent dopamine transporter and Sodium-dependent nor... 4 19
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 4 12
Sodium-dependent dopamine transporter and Sodium-dependent ser... 2 0
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 6 5
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 2 11
Sigma non-opioid intracellular receptor 1 ligand 2-[(3R)-1'-(c... 2 0
Muscarinic acetylcholine receptor M1 and Muscarinic acetylchol... 1 2
Mu-type opioid receptor and Sigma non-opioid intracellular rec... 10 20
Glutamate receptor ionotropic, NMDA 1 and Glutamate receptor i... 2 8
Substance-P receptor ligand AGN-PC-02K8FR family 1 3
Sodium-dependent dopamine transporter and Sodium-dependent ser... 1 0
D(2) dopamine receptor and D(1A) dopamine receptor ligand ISOM... 2 5
Sigma non-opioid intracellular receptor 1 and D(2) dopamine re... 11 2
Transporter and Sodium-dependent serotonin transporter inhibit... 1 5
Sodium-dependent dopamine transporter and Transporter inhibito... 2 0
Sodium-dependent serotonin transporter and Alpha-2A adrenergic... 2 2
Kappa-type opioid receptor ligand CHEMBL2367762 family 2 0
Histamine H3 receptor and Sodium-dependent serotonin transport... 3 6
Substance-P receptor ligand SureCN8415737 family 3 4
Sodium-dependent serotonin transporter and Sodium-dependent do... 3 0
Sodium-dependent dopamine transporter and Sodium-dependent ser... 2 6
Sodium-dependent dopamine transporter and Sigma non-opioid int... 2 0
Sodium-dependent dopamine transporter and Sodium-dependent ser... 2 0
Vesicular acetylcholine transporter inhibitor (2R,3R)-5-(3-flu... 2 0
Histamine H1 receptor and 5-hydroxytryptamine receptor 2A liga... 1 0
Cytochrome P450 2D6 and Sodium channel protein type 1 subunit ... 1 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00361029 CHEMBL146547 Bioactive 2-[3-[4-(2-benzhydryloxyethyl)piperazin-1-yl]propyl]phenol

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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