CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM5071
Family Name 5-hydroxytryptamine receptor 4 ligand 6-chloro-N-[[1-(2-methylpropyl)piperidin-4-yl]methyl]-1H-benzimidazole-4-carboxamide family
No. of Seeds 10 No. of Other Members 19
Family Centroid CFAMM00361092 Functional Category Bioactive
Superfamily Dipeptidyl peptidase 4 and 5-hydroxytryptamine receptor 4 Binder Superfamily
Class Class 1060

Cousin Family NamesSeedsMembers
Vasopressin V1a receptor and Vasopressin V2 receptor Ligand be... 4 301
5-hydroxytryptamine receptor Ligand Ramosetron Family 10 219
Tubulin beta chain Inhibitor Mebendazole Family 12 84
Prothrombin Inhibitor Dabigatran Family 7 182
BIBT986 family 7 96
CC-486 family 7 103
Vascular endothelial growth factor receptor 2 Ligand XL999 Family 11 87
Kappa-type opioid receptor Ligand Brl 52974 Family 2 27
Histamine H3 receptor Ligand SCH79687 Family 11 29
Vascular endothelial growth factor receptor 2 Ligand 6-(1h-ben... 2 5
Telomerase reverse transcriptase Inhibitor HOE-33258 Family 10 33
Herpes simplex virus type 1 thymidine kinase Inhibitor N2-(3-t... 1 2
Tyrosine-protein kinase Lck and Tyrosine-protein kinase HCK in... 1 4
Acetylcholinesterase inhibitor SureCN251059 family 2 16
Mu-type opioid receptor and Mu-type opioid receptor ligand Sur... 5 10
Poly [ADP-ribose] polymerase 1 inhibitor 2-(3-chlorophenyl)-1H... 4 38
Tyrosine-protein kinase BTK and Tyrosine-protein kinase Lyn in... 7 7
Platelet-activating factor receptor ligand SureCN9523843 family 4 4
RAC-alpha serine/threonine-protein kinase inhibitor SureCN4728... 11 6
Histamine H4 receptor ligand SureCN602132 family 1 8
Melanin-concentrating hormone receptor 1 ligand AGN-PC-088XRP ... 2 10
Cyclin-A2 and Cyclin-dependent kinase 2 inhibitor AGN-PC-09M45... 8 1
Cell division cycle 7-related protein kinase and Cyclin-depend... 2 9
Cell division cycle 7-related protein kinase inhibitor pyrrolo... 4 10
Poly [ADP-ribose] polymerase 1 inhibitor SureCN6202744 family 4 2
Peroxisome proliferator-activated receptor gamma ligand 1-[(4-... 7 29
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 3 1
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 4 2
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 6 2
cGMP-dependent 3',5'-cyclic phosphodiesterase and cAMP and cAM... 8 13
Gonadotropin-releasing hormone receptor ligand 1-(3-azabicyclo... 9 10
Prothrombin inhibitor AGN-PC-09QLAK family 10 2
Lysosomal Pro-X carboxypeptidase inhibitor N-[(1S)-1-(5,6-dich... 3 21
Adenosine receptor A2a and Adenosine receptor A2b ligand SureC... 2 2
MAP kinase-activated protein kinase 2 inhibitor AGN-PC-0A9QGC ... 14 0
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 10 14
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 5 8
Coagulation factor X and Prothrombin inhibitor 2-carboxyindole... 2 8
Histamine H3 receptor and Potassium voltage-gated channel subf... 7 1
Histamine H3 receptor ligand SureCN2878688 family 8 1
5-hydroxytryptamine receptor 4 ligand AGN-PC-00PM3Y family 4 3
Coagulation factor X inhibitor SureCN8289965 family 4 5
Delta-type opioid receptor ligand ethyl N-[3-[(R)-[4-[ethyl(me... 2 6
Melanin-concentrating hormone receptor 1 ligand AGN-PC-075X3N ... 1 7
Casein kinase II subunit alpha and Serine/threonine-protein ki... 1 5
Cytochrome P450 3A4 and Insulin-like growth factor 1 receptor ... 24 57
Histamine H3 receptor ligand 1-[4-(1H-imidazol-5-ylmethyl)pipe... 1 2
Vascular endothelial growth factor receptor 2 ligand (3Z)-3-[5... 4 11
Vascular endothelial growth factor receptor 2 ligand (3Z)-6-fl... 4 3
Platelet-derived growth factor receptor beta and Vascular endo... 5 12
Glycogen synthase kinase-3 beta inhibitor 2-(4-fluorophenyl)-N... 4 2
Urokinase plasminogen activator surface receptor ligand ethyl ... 1 0
Coagulation factor X inhibitor 3-chloro-N-[(1S,2S)-2-[[4-(2-ox... 22 3
Melanocortin receptor 4 ligand AGN-PC-076AMO family 17 8
Transient receptor potential cation channel subfamily V member... 1 1
5-hydroxytryptamine receptor 4 and 5-hydroxytryptamine recepto... 10 1
Coagulation factor X and Prothrombin inhibitor SureCN6593603 f... 3 0
Disintegrin and metalloproteinase domain-containing protein 17... 10 4
RAF proto-oncogene serine/threonine-protein kinase and Serine/... 4 3
Alpha-1A adrenergic receptor and Alpha-1B adrenergic receptor ... 3 0
Matrilysin and Stromelysin-1 inhibitor (2R)-N-[(1S)-1-(1H-benz... 3 0
Substance-K receptor ligand SureCN9035669 family 10 5
Thromboxane-A synthase inhibitor 6-chloro-3-(4-imidazol-1-ylbu... 12 21
Coagulation factor X inhibitor SureCN1652469 family 2 1
Coagulation factor X inhibitor AGN-PC-078Y0T family 11 0
Serine/threonine-protein kinase Chk1 inhibitor CHIR-124 family 1 0
Coagulation factor X inhibitor SureCN8290907 family 2 2
Corticotropin-releasing factor receptor 1 and Corticotropin-re... 2 1
Cyclin-dependent kinase 2 and Potassium voltage-gated channel ... 12 7
Tyrosine-protein kinase ITK/TSK and Insulin receptor ligand AG... 5 1
Platelet-derived growth factor receptor beta and Fibroblast gr... 10 0
Melanin-concentrating hormone receptor 1 ligand SureCN3834858 ... 2 1
Dipeptidyl peptidase 4 inhibitor SureCN5776796 family 1 0
Platelet-derived growth factor receptor beta and Fibroblast gr... 2 1
Poly [ADP-ribose] polymerase 1 inhibitor 2-[4-(5-sulfanylidene... 1 1
Poly [ADP-ribose] polymerase 1 and Poly [ADP-ribose] polymeras... 4 0
Sonic hedgehog protein and Cytochrome P450 2C9 inhibitor AGN-P... 1 0
Tyrosine-protein kinase Lck and Tyrosine-protein kinase Lyn in... 1 0
Cannabinoid receptor 2 ligand [(4S,4aR,8aS)-4-hydroxy-4-phenyl... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00361103 CHEMBL97594 Bioactive AC1NT4W2
CFAMM00361093 CHEMBL460261 Bioactive AGN-PC-04XLBL
CFAMM00361109 CHEMBL329487 Bioactive 6-chloro-N-[[1-[2-(methanesulfonamido)ethyl]piperidin-4-yl]methyl]-1H-benzimidazole-4-carboxamide
CFAMM00361092 CHEMBL262950 Bioactive 6-chloro-N-[[1-(2-methylpropyl)piperidin-4-yl]methyl]-1H-benzimidazole-4-carboxamide
CFAMM00361091 CHEMBL149558 Bioactive AC1LO8ZU
CFAMM00361107 CHEMBL94880 Bioactive N-[(1-butylpiperidin-4-yl)methyl]-6-chloro-1H-benzimidazole-4-carboxamide
CFAMM00361096 CHEMBL97955 Bioactive AGN-PC-074QMX

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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