CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM5082
Family Name 5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine receptor 3B ligand AC1LGS75 family
No. of Seeds 4 No. of Other Members 2
Family Centroid CFAMM00361179 Functional Category Bioactive
Superfamily 5-hydroxytryptamine receptor 3B and 5-hydroxytryptamine receptor 3A Binder Superfamily 5
Class Class 4106

Cousin Family NamesSeedsMembers
Vasopressin V1a receptor and Vasopressin V2 receptor Ligand be... 4 301
Gamma-aminobutyric acid A receptor Ligand imidazopyridine deri... 5 644
Mast/stem cell growth factor receptor Kit and Abelson tyrosine... 6 537
5-hydroxytryptamine receptor Ligand Ramosetron Family 10 219
Tubulin beta chain Inhibitor Mebendazole Family 12 84
Peptide deformylase, mitochondrial inhibitor folic acid analog... 59 98
Histamine H1 receptor Ligand Mizolastine Family 14 603
Prothrombin Inhibitor Dabigatran Family 7 182
C-X-C chemokine receptor type 4 Ligand AMD-070 Family 12 800
Purine nucleoside phosphorylase Inhibitor BCX-34 Family 2 31
Dipeptidyl peptidase 4 Inhibitor Linagliptin Family 10 81
Protein kinase C alpha type and Protein kinase C beta type Inh... 16 86
BIBT986 family 7 96
SB989 family 17 91
PHA848125 family 13 138
CC-486 family 7 103
JAK Inhibitor Momelotinib Family 33 83
Vascular endothelial growth factor receptor 2 Ligand XL999 Family 11 87
XL-888 family 16 85
Platelet activating factor, putative Inhibitor ABT-491 Family 22 62
Vascular endothelial growth factor receptor 2 Ligand 6-(1h-ben... 2 5
Adenosine receptor A3 Ligand 1-benzyl-1h-1,3,4b,9-tetraaza-flu... 19 165
Telomerase reverse transcriptase Inhibitor HOE-33258 Family 10 33
Melanocortin receptor Ligand Ac-his-dnal(2)-arg-trp-nh2 Family 112 67
Adenosine receptor A1 and Adenosine receptor A3 Ligand VUF-850... 28 47
Cyclin-dependent kinase 2 and Cyclin-dependent kinase 9 Inhibi... 2 3
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 24 79
Proto-oncogene tyrosine-protein kinase Src Inhibitor 5,7-diphe... 2 11
Herpes simplex virus type 1 thymidine kinase Inhibitor N2-(3-t... 1 2
Bombesin receptor subtype-3 and Gastrin-releasing peptide rece... 42 7
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 1 2
Prothrombin and Cationic trypsin inhibitor (2S)-N-[(2S)-1-(1H-... 4 15
5-hydroxytryptamine receptor 1F and 5-hydroxytryptamine recept... 8 12
Acetylcholinesterase inhibitor SureCN251059 family 2 16
Adenosine receptor A2a and Adenosine receptor A1 ligand 2-amin... 10 48
Mu-type opioid receptor and Mu-type opioid receptor ligand Sur... 5 10
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 2 12
Poly [ADP-ribose] polymerase 1 inhibitor 2-(3-chlorophenyl)-1H... 4 38
Cyclin-A2 and Cyclin-dependent kinase 2 inhibitor AGN-PC-07ZE3... 6 1
Platelet-activating factor receptor ligand SureCN9523843 family 4 4
Macrophage colony-stimulating factor 1 receptor and Cytochrome... 13 3
Histamine H4 receptor ligand SureCN602132 family 1 8
Transient receptor potential cation channel subfamily V member... 1 4
Serine/threonine-protein kinase D1 and Polycystin-2 inhibitor ... 3 7
Cannabinoid receptor 2 ligand AGN-PC-080WIY family 1 0
Cathepsin K and Potassium voltage-gated channel subfamily H me... 4 7
Carbonic anhydrase 9 and Carbonic anhydrase 2 inhibitor AGN-PC... 2 4
Adenosine receptor A2a ligand AGN-PC-01LVXW family 2 25
Adenosine receptor A2a ligand SureCN14156209 family 3 2
Cyclin-A2 and Cyclin-dependent kinase 2 inhibitor AGN-PC-09M4U... 4 5
Cyclin-A2 and Cyclin-dependent kinase 2 inhibitor AGN-PC-09M45... 8 1
Cell division cycle 7-related protein kinase and Cyclin-depend... 2 9
Cell division cycle 7-related protein kinase inhibitor pyrrolo... 4 10
Adenosine receptor A3 ligand N-(5-methyl-2-phenylpyrazolo[4,3-... 5 8
C-C chemokine receptor type 5 ligand SureCN1573831 family 4 3
Peroxisome proliferator-activated receptor gamma ligand 1-[(4-... 7 29
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 3 1
5-hydroxytryptamine receptor 4 ligand 6-chloro-N-[[1-(2-methyl... 10 19
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 6 2
Cellular tumor antigen p53 and Microtubule-associated protein ... 1 1
Melanocortin receptor 4 ligand AGN-PC-076AML family 3 24
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 2 0
Gonadotropin-releasing hormone receptor ligand 1-(3-azabicyclo... 9 10
Prothrombin inhibitor AGN-PC-09QLAK family 10 2
Adenosine receptor A2a and Adenosine receptor A2b ligand SureC... 2 2
Tyrosine-protein kinase ITK/TSK and Receptor-type tyrosine-pro... 1 0
MAP kinase-activated protein kinase 2 inhibitor AGN-PC-0A9QGC ... 14 0
Glycogen synthase kinase-3 alpha and Glycogen synthase kinase-... 15 7
MAP kinase-activated protein kinase 2 inhibitor CHEMBL1801305 ... 2 0
Mitogen-activated protein kinase 14 inhibitor N-ethyl-5-methyl... 17 3
Mitogen-activated protein kinase 14 and Mitogen-activated prot... 13 3
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 10 14
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 5 8
Renin inhibitor [2-[(3-fluoro-2-methylphenyl)methyl]-6-methyl-... 2 1
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK3 ... 14 2
Histamine H3 receptor and Potassium voltage-gated channel subf... 7 1
Histamine H3 receptor ligand SureCN2878688 family 8 1
Protein-tyrosine kinase 6 and KH domain-containing, RNA-bindin... 21 6
Coagulation factor X and Coagulation factor IX inhibitor 5-ami... 9 4
5-hydroxytryptamine receptor 4 ligand AGN-PC-00PM3Y family 4 3
Histamine H1 receptor and Histamine H4 receptor ligand [4-[2-[... 1 1
MAP kinase-activated protein kinase 2 inhibitor 4-fluoro-N-[4-... 25 1
Coagulation factor X inhibitor SureCN8289965 family 4 5
Ribosomal protein S6 kinase alpha-3 inhibitor N-(3-ethylimidaz... 2 2
3-phosphoinositide-dependent protein kinase 1 and RAC-alpha se... 10 4
Delta-type opioid receptor ligand ethyl N-[3-[(R)-[4-[ethyl(me... 2 6
Melanin-concentrating hormone receptor 1 ligand AGN-PC-075X3N ... 1 7
Dipeptidyl peptidase 4 and Cytochrome P450 3A4 inhibitor 6-[(3... 10 0
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 5 3
Casein kinase II subunit alpha and Serine/threonine-protein ki... 1 5
Insulin-like growth factor 1 receptor and Mitogen-activated pr... 3 4
Aurora kinase B and Aurora kinase A inhibitor 4-amino-N-[3-[[(... 5 3
Heat shock protein HSP 90-beta inhibitor 1-(2-amino-4-methylqu... 1 2
Vascular endothelial growth factor receptor 2 ligand (3Z)-3-[5... 4 11
Vascular endothelial growth factor receptor 2 ligand (3Z)-6-fl... 4 3
Platelet-derived growth factor receptor beta and Vascular endo... 5 12
Dipeptidyl peptidase 4 inhibitor 2-[[2-[(3R)-3-aminopiperidin-... 1 0
Glycogen synthase kinase-3 beta inhibitor 2-(4-fluorophenyl)-N... 4 2
Cyclin-dependent kinase 2 and Serine/threonine-protein kinase ... 2 2
Lysine--tRNA ligase inhibitor N-[2-(2-piperazin-1-ylpyridin-4-... 5 0
Glutamate receptor ionotropic, NMDA 1 and Glutamate receptor i... 4 1
ALK tyrosine kinase receptor ligand N-[6-[[4-(2-hydroxypropan-... 2 0
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 3 1
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 5 6
Serine/threonine-protein kinase Chk1 inhibitor SureCN5547496 f... 2 1
Serine/threonine-protein kinase TBK1 inhibitor N-[3-[[5-cyclop... 5 0
P2X purinoceptor 7 inhibitor SureCN109432 family 10 28
cGMP-dependent 3',5'-cyclic phosphodiesterase and cAMP and cAM... 3 0
Melanocortin receptor 4 ligand AGN-PC-076AMO family 17 8
Melanocortin receptor 4 ligand AGN-PC-076AMT family 2 9
Dipeptidyl peptidase 4 inhibitor 2-[(3R)-3-aminopiperidin-1-yl... 3 4
5-hydroxytryptamine receptor 4 and 5-hydroxytryptamine recepto... 10 1
Serine/threonine-protein kinase mTOR inhibitor 1-ethyl-3-[4-[6... 4 1
Orexin receptor type 2 and Orexin receptor type 1 ligand 9-(4,... 2 8
cAMP-specific 3',5'-cyclic phosphodiesterase 4B inhibitor 4-[4... 1 1
Histone deacetylase 1 inhibitor 1-methyl-N-[(1S)-7-oxo-1-(5-qu... 2 3
Phospholipase D1 and Phospholipase D2 inhibitor SureCN10311349... 2 14
Disintegrin and metalloproteinase domain-containing protein 17... 10 4
Metabotropic glutamate receptor 2 ligand 8-(2,5-difluorophenyl... 6 2
Alpha-1A adrenergic receptor and Alpha-1B adrenergic receptor ... 3 0
Matrilysin and Stromelysin-1 inhibitor (2R)-N-[(1S)-1-(1H-benz... 3 0
Dihydrofolate reductase and Bifunctional dihydrofolate reducta... 3 2
Substance-K receptor ligand SureCN9035669 family 10 5
Thromboxane-A synthase inhibitor 6-chloro-3-(4-imidazol-1-ylbu... 12 21
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 2 0
5-hydroxytryptamine receptor 1A and Alpha-1B adrenergic recept... 2 0
Coagulation factor X inhibitor AGN-PC-078Y0T family 11 0
Serine/threonine-protein kinase Chk1 inhibitor CHIR-124 family 1 0
Cell division cycle 7-related protein kinase inhibitor Pyrrolo... 2 6
Epidermal growth factor receptor ligand (E)-5-[4-(3-bromoanili... 11 0
Cyclin-dependent kinase 2 and Potassium voltage-gated channel ... 12 7
Tyrosine-protein kinase ITK/TSK inhibitor AGN-PC-077RDJ family 15 1
Cyclin-dependent kinase 2 inhibitor SureCN3549598 family 3 1
Tyrosine-protein kinase ITK/TSK and Insulin receptor ligand AG... 5 1
Melanin-concentrating hormone receptor 1 ligand SureCN3832854 ... 3 2
Platelet-derived growth factor receptor beta and Fibroblast gr... 10 0
Melanin-concentrating hormone receptor 1 ligand SureCN3834858 ... 2 1
Dipeptidyl peptidase 4 inhibitor SureCN5776796 family 1 0
Egl nine homolog 1 inhibitor 2-[(1,6-diphenylimidazo[4,5-c]pyr... 1 5
Platelet-derived growth factor receptor beta and Fibroblast gr... 2 1
Poly [ADP-ribose] polymerase 1 inhibitor 2-[4-(5-sulfanylidene... 1 1
LIM domain kinase 2 inhibitor 3-[[(cyanoamino)-[(2S)-2-methyl-... 6 0
Poly [ADP-ribose] polymerase 1 and Poly [ADP-ribose] polymeras... 4 0
Sonic hedgehog protein and Cytochrome P450 2C9 inhibitor AGN-P... 1 0
Neuropeptide Y receptor type 5 ligand SureCN8149543 family 1 0
Cannabinoid receptor 2 ligand [(4S,4aR,8aS)-4-hydroxy-4-phenyl... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00361179 CHEMBL147549 Bioactive AC1LGS75

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

46076 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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