CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM509
Family Name Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform and Serine/threonine-protein kinase mTOR inhibitor N-[2-(dimethylamino)ethyl]-4-[[(2E)-2-[[5-methoxy-2-(1,3,5-trimethylpyrazol-4-yl)-1H-indol-3-yl]methylidene]-3-oxo-1-benzofuran-5-yl]carbamoylamino]-N-methylbenzamide family
No. of Seeds 9 No. of Other Members 0
Family Centroid CFAMM00312486 Functional Category Bioactive
Superfamily Receptor-type tyrosine-protein kinase FLT3 and Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform Binder Superfamily
Class Class 3172

Cousin Family NamesSeedsMembers
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor indole... 28 2712
72 kDa type IV collagenase and Matrix metalloproteinase-9 Inhi... 37 265
Adenosine receptor A1 and Adenosine receptor A2a Ligand SB-298... 53 320
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 7 44
Disintegrin and metalloproteinase domain-containing protein 17... 14 9
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 1 14
Disintegrin and metalloproteinase domain-containing protein 17... 2 8
Histamine H3 receptor ligand AGN-PC-00BG7Z family 11 49
D(3) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 10 50
Proto-oncogene tyrosine-protein kinase receptor Ret and Vascul... 5 14
Disintegrin and metalloproteinase domain-containing protein 17... 5 4
Alpha-1D adrenergic receptor and Alpha-1A adrenergic receptor ... 1 1
Cathepsin K inhibitor N-[(2S)-4-methyl-1-[2-[4-(2-methylpropox... 4 0
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor CHEMBL4... 6 2
Signal transducer and activator of transcription 1-alpha/beta ... 1 36


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00312487 CHEMBL1082616 Bioactive 1-[(2E)-2-[[7-fluoro-5-methoxy-2-(1,3,5-trimethylpyrazol-4-yl)-1H-indol-3-yl]methylidene]-3-oxo-1-benzofuran-5-yl]-3-pyridin-3-ylurea
CFAMM00312480 CHEMBL1082621 Bioactive N-[2-(dimethylamino)ethyl]-4-[[(2E)-2-[[7-fluoro-5-methoxy-2-(1,3,5-trimethylpyrazol-4-yl)-1H-indol-3-yl]methylidene]-3-oxo-1-benzofuran-5-yl]carbamoylamino]-N-methylbenzamide
CFAMM00312486 CHEMBL1082619 Bioactive N-[2-(dimethylamino)ethyl]-4-[[(2E)-2-[[5-methoxy-2-(1,3,5-trimethylpyrazol-4-yl)-1H-indol-3-yl]methylidene]-3-oxo-1-benzofuran-5-yl]carbamoylamino]-N-methylbenzamide
CFAMM00312485 CHEMBL1082618 Bioactive 1-[(2E)-2-[[5-methoxy-2-(1,3,5-trimethylpyrazol-4-yl)-1H-indol-3-yl]methylidene]-3-oxo-1-benzofuran-5-yl]-3-[4-(4-methylpiperazine-1-carbonyl)phenyl]urea
CFAMM00312484 CHEMBL1083912 Bioactive 1-[(2E)-2-[[5-methoxy-2-(1,3,5-trimethylpyrazol-4-yl)-1H-indol-3-yl]methylidene]-3-oxo-1-benzofuran-5-yl]-3-methylurea
CFAMM00312483 CHEMBL1083305 Bioactive 1-[(2E)-2-[[7-fluoro-5-methoxy-2-(1,3,5-trimethylpyrazol-4-yl)-1H-indol-3-yl]methylidene]-3-oxo-1-benzofuran-5-yl]-3-methylurea
CFAMM00312482 CHEMBL1082986 Bioactive 1-[(2E)-2-[[5-methoxy-2-(1,3,5-trimethylpyrazol-4-yl)-1H-indol-3-yl]methylidene]-3-oxo-1-benzofuran-5-yl]-3-pyridin-3-ylurea
CFAMM00312488 CHEMBL1082617 Bioactive 1-[(2E)-2-[[5-methoxy-2-(1,3,5-trimethylpyrazol-4-yl)-1H-indol-3-yl]methylidene]-3-oxo-1-benzofuran-5-yl]-3-[4-(morpholine-4-carbonyl)phenyl]urea
CFAMM00312481 CHEMBL1082620 Bioactive 1-[(2E)-2-[[7-fluoro-5-methoxy-2-(1,3,5-trimethylpyrazol-4-yl)-1H-indol-3-yl]methylidene]-3-oxo-1-benzofuran-5-yl]-3-[4-(morpholine-4-carbonyl)phenyl]urea

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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