CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM5096
Family Name Nociceptin receptor and Kappa-type opioid receptor ligand 1-[1-(1-methylcyclooctyl)piperidin-4-yl]-2-[(3S)-1-methylpiperidin-3-yl]benzimidazole family
No. of Seeds 4 No. of Other Members 4
Family Centroid CFAMM00111507 Functional Category Bioactive
Superfamily Histamine H1 receptor Ligand Mizolastine Superfamily
Class Class 667

Cousin Family NamesSeedsMembers
5-hydroxytryptamine receptor 1D Ligand Rizatriptan Family 7 460
Alpha-2 adrenergic receptor Ligand Dexmedetomidine Family 32 639
Benzodiazepine receptor Ligand Midazolam Family 5 160
Toll-like receptor 7 Ligand Imiquimod Family 3 237
Histamine H1 receptor Ligand Emedastine Family 5 115
Histamine H1 receptor Ligand Mizolastine Family 14 603
Metabotropic glutamate receptor 5 Ligand ADX-48621 Family 15 444
C-X-C chemokine receptor type 4 Ligand AMD-070 Family 12 800
Vascular endothelial growth factor Inhibitor PTC299 Family 6 145
Cyclin-dependent kinase 2 Inhibitor Seliciclib Family 29 292
Fibroblast growth factor receptor 2 and Fibroblast growth fact... 11 86
Translocator protein Inhibitor Emapunil Family 7 89
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 14 234
HCV NS4B protein Inhibitor Clemizole Family 2 43
Genomic RNA for RNA-dependent RNA polymerase gene (clone HCV-J... 13 55
BIBT986 family 7 96
SB989 family 17 91
Corticotropin-releasing factor receptor 1 Ligand CP-154526 Family 9 29
Tryptase Inhibitor Babim Family 12 90
D(4) dopamine receptor Ligand L-745,870 Family 30 205
Corticotropin-releasing factor receptor 1 Ligand R121919 Family 26 84
Prostaglandin G/H synthase 2 Inhibitor RWJ-67657 Family 3 33
Beta-secretase 1 Inhibitor N~3~-(3-pyridin-3-ylbenzyl)pyridine... 31 66
Adenosine receptor A1 and Adenosine receptor A2a Ligand 2,6-di... 13 14
Steroid 17-alpha-hydroxylase/17,20 lyase and Aromatase Inhibit... 18 109
Cytochrome P450 11B1, mitochondrial Inhibitor 1-(4-cyanobenzyl... 14 13
Epidermal growth factor receptor Ligand PD-158780 Family 98 89
Arachidonate 5-lipoxygenase Inhibitor 2,4,5-triarylimidazole A... 3 16
Methionine aminopeptidase 2 Inhibitor 2-(pyridin-2-yl)-1h-benz... 6 19
Aromatase and Thromboxane-A synthase Inhibitor 6-(1h-imidazol-... 3 8
Metabotropic glutamate receptor 5 Ligand 3-(4-pyridin-2-yl-imi... 6 5
Adenosine receptor A3 Ligand 1-benzyl-1h-1,3,4b,9-tetraaza-flu... 19 165
Mitogen-activated protein kinase 3 and RAF proto-oncogene seri... 8 5
Histamine H3 receptor Ligand 2-(4-isopropyl-piperazin-1-yl)-qu... 17 29
Alpha-1A adrenergic receptor Ligand A-315456 Family 7 17
Adenosine receptor A3 Ligand 2-(5-chloro-1h-benzo[d]imidazol-2... 7 51
Adenosine receptor A3 Ligand 2-(4-nitro-1h-benzo[d]imidazol-2-... 2 12
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 5 45
Dipeptidyl peptidase 4 Inhibitor (5-phenyl-3h-benzo[d]imidazol... 5 13
Histamine H4 receptor Ligand A-943931 Family 14 11
RAF proto-oncogene serine/threonine-protein kinase Inhibitor L... 219 124
Farnesyl pyrophosphate synthase Inhibitor [2-(benzoimidazol-1-... 2 16
Potassium voltage-gated channel subfamily H member 2 Ligand AZ... 21 42
Cytochrome P450 11B1, mitochondrial Inhibitor 1-(4-bromobenzyl... 3 0
Histamine H3 receptor Ligand 4-(2-(phenylamino)ethyl)-1h-imida... 5 16
Type-2 angiotensin II receptor Ligand L-158809 Family 22 136
Sodium channel protein type 1 subunit alpha and Sodium channel... 10 14
Amine oxidase [flavin-containing] A Inhibitor 3-benzyl-n-(2-mo... 2 3
Nitric oxide synthase, inducible and Nitric oxide synthase, br... 1 4
Acetylcholinesterase inhibitor SureCN251059 family 2 16
Dihydrofolate reductase and Bifunctional dihydrofolate reducta... 3 9
Corticotropin-releasing factor receptor 1 ligand N-(cyclopropy... 2 10
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 4 2
Thromboxane-A synthase inhibitor AGN-PC-00N7V2 family 3 6
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 1 7
Glutamate receptor ionotropic, NMDA 1 and Glutamate receptor i... 4 3
Platelet-activating factor receptor ligand AGN-PC-0750SP family 4 0
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 7 4
Histamine H3 receptor ligand SureCN4018269 family 1 0
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 7 10
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 2 1
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 1 0
Vascular endothelial growth factor receptor 2 and Mitogen-acti... 2 2
C-C chemokine receptor type 5 ligand SureCN1573831 family 4 3
D(4) dopamine receptor and D(2) dopamine receptor ligand 4-met... 13 8
Growth hormone secretagogue receptor type 1 and Dihydrofolate ... 3 6
Histamine H4 receptor ligand (2Z)-5-chloro-2-[(1-methylpiperid... 2 8
C-C chemokine receptor type 5 and Potassium voltage-gated chan... 21 32
Transient receptor potential M8 protein ligand 2-[(E)-2-(oxan-... 5 3
Nociceptin receptor and Kappa-type opioid receptor ligand AGN-... 5 2
Nociceptin receptor and Mu-type opioid receptor ligand AGN-PC-... 3 0
Coagulation factor X and Cationic trypsin inhibitor AGN-PC-075... 5 13
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 1 2
Melanin-concentrating hormone receptor 1 ligand SureCN3334191 ... 4 7
Signal transducer and activator of transcription 6 inhibitor A... 3 0
C-C chemokine receptor type 5 ligand methyl N-cyano-4-[2-[(1R,... 8 8
C-C chemokine receptor type 5 ligand [4-[2-[3-(2-ethylbenzimid... 5 12
Fatty-acid amide hydrolase 1 inhibitor [5-(4-chlorophenyl)tria... 2 2
Sodium-dependent dopamine transporter and Sodium-dependent nor... 2 3
Progesterone receptor ligand AGN-PC-00B9AT family 4 4
Mitogen-activated protein kinase 14 inhibitor 6-[5-(2,4-difluo... 9 3
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 2 0
Histamine H1 receptor and Potassium voltage-gated channel subf... 1 2
Serine/threonine-protein kinase pim-1 and Serine/threonine-pro... 2 2
Neuronal acetylcholine receptor subunit beta-2 and Neuronal ac... 10 6
Platelet-derived growth factor receptor beta and Vascular endo... 5 12
TGF-beta receptor type-1 and TGF-beta receptor type-2 ligand S... 2 2
Cannabinoid receptor 2 ligand 8-(2-chlorophenyl)-9-cyclopropyl... 4 5
Translocator protein inhibitor N-butan-2-yl-4-(2-chlorophenyl)... 14 12
Neuropeptide Y receptor type 5 ligand 2-(3-phenylpiperidin-1-y... 6 2
C-C chemokine receptor type 3 ligand 5-fluoro-1-[1-[3-(4-fluor... 1 2
C-C chemokine receptor type 5 and Potassium voltage-gated chan... 2 1
Mitogen-activated protein kinase 14 inhibitor 6-[2-(2,6-difluo... 3 0
Corticotropin-releasing factor receptor 1 and Corticotropin-re... 2 1
Corticotropin-releasing factor receptor 1 and Corticotropin-re... 6 3
Melanin-concentrating hormone receptor 1 and Potassium voltage... 4 4
D(2) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 2 2
Type-1 angiotensin II receptor ligand SureCN7390271 family 2 1
C-C chemokine receptor type 5 ligand 1-[4-(3-chlorophenyl)-4-[... 3 1
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 2 0
Cyclin-dependent kinase 2 inhibitor SureCN3549598 family 3 1
Nociceptin receptor and Mu-type opioid receptor ligand 2-(3-ch... 2 0
B1 bradykinin receptor ligand AGN-PC-077LWO family 2 0
5-hydroxytryptamine receptor 2B ligand SureCN1299053 family 1 1
Dipeptidyl peptidase 4 and Potassium voltage-gated channel sub... 1 0
Tyrosine-protein kinase Lck inhibitor (3S)-3-[(1S)-1-[[4-(benz... 14 0
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 1 5
Survival motor neuron protein and 15-hydroxyprostaglandin dehy... 1 1
Small conductance calcium-activated potassium channel protein ... 1 0
D(2) dopamine receptor and D(4) dopamine receptor ligand 3-[1-... 1 0
Substance-P receptor ligand 2-[1-ethyl-2-[(E,3Z)-3-(1,3,3-trim... 2 3


CFAM Mol ID

External ID

Functional Category

Molecule Name


Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

25231 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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