CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM5100
Family Name Coagulation factor X inhibitor AGN-PC-078Y4E family
No. of Seeds 4 No. of Other Members 6
Family Centroid CFAMM00361324 Functional Category Bioactive
Superfamily Coagulation factor X and cAMP-specific 3',5'-cyclic phosphodiesterase 4A Binder Superfamily
Class Class 1209

Cousin Family NamesSeedsMembers
Abelson tyrosine-protein kinase 2 inhibitor thiazole derivativ... 19 50
Reverse transcriptase Inhibitor Nevirapine Family 23 640
Transient receptor potential cation channel subfamily V member... 16 295
Edoxaban Tosylate family 3 3
Histone deacetylase 6 Inhibitor ACY-1215 Family 10 230
XL-888 family 16 85
Bacterial outer membrane Inhibitor HKI-9924129 Family 19 85
Tubulin beta chain Inhibitor 2-(3-chloro-phenyl)-1h-[1,8]napht... 3 13
D(2) dopamine receptor and D(3) dopamine receptor Ligand Azape... 7 102
Nitric oxide synthase, inducible and Nitric oxide synthase, br... 4 6
Poly [ADP-ribose] polymerase 1 Inhibitor N-(4-phenylthiazol-2-... 6 150
Bifunctional epoxide hydrolase 2 Inhibitor 6-amino-n-(2,4-dich... 10 116
Glutamate receptor 1 Ligand Piriqualone Family 8 67
Reverse transcriptase/RNaseH inhibitor AC1LAJTF family 6 5
Serine/threonine-protein kinase pim-2 and Serine/threonine-pro... 6 9
Sonic hedgehog protein inhibitor 3-chloro-N-[4-(methylamino)cy... 2 3
Serine/threonine-protein kinase Chk1 inhibitor SureCN13010134 ... 7 29
Nicotinamide phosphoribosyltransferase inhibitor 4-[(7-chloro-... 6 4
Coagulation factor X inhibitor AGN-PC-075AY8 family 28 21
Serine/threonine-protein kinase Chk1 inhibitor SureCN3070314 f... 16 32
Serine/threonine-protein kinase Chk1 inhibitor 2-(1-methylindo... 3 4
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK1 ... 8 1
C-X-C chemokine receptor type 3 ligand SureCN13205646 family 4 0
Coagulation factor X and Kallikrein-1 inhibitor SureCN890858 f... 5 6
Coagulation factor X inhibitor AGN-PC-078Y3A family 4 1
Metabotropic glutamate receptor 1 ligand AGN-PC-0A9TG5 family 11 10
Nicotinamide phosphoribosyltransferase inhibitor 4-[[(7-chloro... 1 1
Coagulation factor X and Prothrombin inhibitor 2-carboxyindole... 2 8
C-X-C chemokine receptor type 3 ligand 5-[(3S)-4-[1-(4-chlorob... 6 0
Coagulation factor X inhibitor 4-[3-[(5-chloropyridin-2-yl)ami... 2 0
C-X-C chemokine receptor type 3 ligand N-[(1R)-1-[3-(4-chlorop... 4 0
Coagulation factor X inhibitor AGN-PC-030DHH family 1 0
Mitogen-activated protein kinase 14 inhibitor N-[4-[2-ETHYL-4-... 4 5
Melanin-concentrating hormone receptor 1 ligand AGN-PC-075X3N ... 1 7
Vascular endothelial growth factor receptor 1 and Receptor-typ... 1 0
Serine/threonine-protein kinase Chk1 and Cyclin-dependent kina... 15 8
Serine/threonine-protein kinase Chk1 and Cyclin-dependent kina... 2 8
Orexin receptor type 2 and Orexin receptor type 1 ligand (2-me... 3 1
Serine/threonine-protein kinase pim-1 and Serine/threonine-pro... 2 1
Melanin-concentrating hormone receptor 1 and Muscarinic acetyl... 8 2
Coagulation factor X inhibitor 5-chloro-N-(5-chloropyridin-2-y... 6 0
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor (4-am... 2 1
Non-receptor tyrosine-protein kinase TYK2 ligand AGN-PC-0D0YSZ... 10 0
Coagulation factor X and Prothrombin inhibitor SureCN6593603 f... 3 0
Coagulation factor X inhibitor 5-bromo-N-(5-chloropyridin-2-yl... 1 1
Coagulation factor X inhibitor AGN-PC-078Y0S family 7 1
Vasopressin V2 receptor and Vasopressin V1a receptor ligand AG... 5 0
Thromboxane-A synthase inhibitor 6-chloro-3-(4-imidazol-1-ylbu... 12 21
Tyrosine-protein kinase Lck inhibitor AGN-PC-074MSE family 18 2
Tyrosine-protein kinase Lck inhibitor AGN-PC-074MPV family 4 0
Coagulation factor X inhibitor AGN-PC-078Y0T family 11 0
Macrophage colony-stimulating factor 1 receptor ligand N-[3-[(... 5 0
Adenosine receptor A1 ligand SureCN1497799 family 2 2
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and Potassium ... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00361324 CHEMBL475185 Bioactive AGN-PC-078Y4E
CFAMM00361322 CHEMBL146207 Bioactive 3-chloro-N-[2-[(5-chloropyridin-2-yl)carbamoyl]-4-methylphenyl]-1-benzothiophene-2-carboxamide
CFAMM00361328 CHEMBL472609 Bioactive AGN-PC-020HAI

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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