CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM5102
Family Name Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ligand 7-[3-[4-(4-fluoro-2-methoxyphenyl)piperazin-1-yl]propylamino]-N,N-dimethyl-1H-pyrazolo[1,5-a]pyrimidin-8-ium-6-carboxamide family
No. of Seeds 2 No. of Other Members 1
Family Centroid CFAMM00361339 Functional Category Bioactive
Superfamily Corticotropin-releasing factor receptor 1 Ligand GW876008 Superfamily
Class Class 1070

Cousin Family NamesSeedsMembers
Corticotropin-releasing factor receptor 1 Ligand CRF-1 Antagon... 29 421
Gamma-secretase subunit APH-1B Inhibitor E2012 Family 3 67
AP26113 family 16 90
Hepatocyte growth factor receptor Ligand Amg 208 Family 20 236
5-hydroxytryptamine receptor 1A Ligand P-MPPI Family 33 81
Vascular endothelial growth factor receptor 2 Ligand L00002164... 6 23
cGMP-specific 3',5'-cyclic phosphodiesterase Inhibitor Cartazo... 11 105
Cyclin-dependent kinase 2 and Cyclin-dependent kinase 4 Inhibi... 19 48
C-X-C chemokine receptor type 3 Ligand AMG-487 Family 28 73
Reverse transcriptase Inhibitor UK-129485 Family 23 221
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 2 28
Adenosine receptor A3 ligand CHEMBL1834696 family 5 18
Ribosomal protein S6 kinase beta-1 and RAC-alpha serine/threon... 1 1
Cellular tumor antigen p53 inhibitor CHEMBL1401545 family 1 25
D(2) dopamine receptor and D(4) dopamine receptor ligand N-[3-... 6 22
D(3) dopamine receptor and D(2) dopamine receptor ligand SureC... 5 4
Dihydrofolate reductase inhibitor AC1LA5HU family 8 4
Dihydrofolate reductase inhibitor AC1L9XPA family 6 5
Bifunctional dihydrofolate reductase-thymidylate synthase and ... 6 13
D(4) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 3 6
Serine/threonine-protein kinase PLK1 inhibitor AGN-PC-0A9RFQ f... 2 1
MAP kinase-activated protein kinase 2 inhibitor AGN-PC-0A9RSG ... 6 5
Receptor-type tyrosine-protein kinase FLT3 and Mast/stem cell ... 2 2
TGF-beta receptor type-1 ligand N-(4-methoxyphenyl)-3-(6-methy... 5 2
Receptor-type tyrosine-protein kinase FLT3 and Mast/stem cell ... 1 3
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 8 1
cGMP-dependent 3',5'-cyclic phosphodiesterase and cAMP and cAM... 3 10
Insulin-like growth factor 1 receptor ligand GSK1220512A family 20 15
Serine/threonine-protein kinase TBK1 and Inhibitor of nuclear ... 2 8
Glycogen synthase kinase-3 beta inhibitor 2-(4-fluorophenyl)-N... 7 3
D(3) dopamine receptor and D(2) dopamine receptor ligand Piper... 3 14
D(4) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 2 2
Glycogen synthase kinase-3 beta and Casein kinase I isoform ga... 3 0
Adenosine receptor A1 ligand ethyl 1-(2-chloro-2-phenylethyl)-... 5 1
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 2 1
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 2 2
Matrix metalloproteinase-9 and Collagenase 3 inhibitor N-hydro... 6 2
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 6 0
Activated CDC42 kinase 1 and Tyrosine-protein kinase Lck inhib... 4 0
Adenosine receptor A2a and Adenosine receptor A1 ligand AGN-PC... 7 5
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 2 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00361339 CHEMBL91547 Bioactive 7-[3-[4-(4-fluoro-2-methoxyphenyl)piperazin-1-yl]propylamino]-N,N-dimethyl-1H-pyrazolo[1,5-a]pyrimidin-8-ium-6-carboxamide
CFAMM00361341 CHEMBL329773 Bioactive 3-chloro-7-[3-[4-(4-fluoro-2-methoxyphenyl)piperazin-1-yl]propylamino]-N,N-dimethyl-1H-pyrazolo[1,5-a]pyrimidin-8-ium-6-carboxamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27038 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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