CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM5141
Family Name Inositol monophosphatase 1 and 15-hydroxyprostaglandin dehydrogenase [NAD(+)] inhibitor CHEMBL1464890 family
No. of Seeds 1 No. of Other Members 0
Family Centroid CFAMM00361696 Functional Category Bioactive
Superfamily Retinal dehydrogenase 1 and Niemann-Pick C1 protein Binder Superfamily 2
Class Class 930

Cousin Family NamesSeedsMembers
Gamma-aminobutyric acid A receptor Ligand imidazopyridine deri... 5 644
Mast/stem cell growth factor receptor Kit and Abelson tyrosine... 6 537
Reverse transcriptase Inhibitor Nevirapine Family 23 640
5-hydroxytryptamine receptor Ligand Ramosetron Family 10 219
Histamine H1 receptor Ligand Mizolastine Family 14 603
Prothrombin Inhibitor Dabigatran Family 7 182
C-X-C chemokine receptor type 4 Ligand AMD-070 Family 12 800
Transient receptor potential cation channel subfamily V member... 6 66
Calcitonin gene-related peptide type 1 receptor Ligand Telcage... 25 124
Cyclin-dependent kinase 4 Inhibitor PD-332991 Family 13 155
Dipeptidyl peptidase 4 Inhibitor Linagliptin Family 10 81
Mast/stem cell growth factor receptor Kit and Vascular endothe... 4 47
Translocator protein Inhibitor Emapunil Family 7 89
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 14 234
Protein kinase C alpha type and Protein kinase C beta type Inh... 16 86
Aurora kinase B and Aurora kinase A Inhibitor PF-03814735 Family 2 12
SB989 family 17 91
GDC-0349 family 44 77
Histone deacetylase Inhibitor JNJ-26481585 Family 2 5
Histone deacetylase 6 Inhibitor ACY-1215 Family 10 230
JAK Inhibitor Momelotinib Family 33 83
Adenosine receptor A1 and Adenosine receptor A2a Ligand 8-phen... 12 213
Adenosine receptor A1 and Adenosine receptor A2b Ligand PSB-11... 34 26
Platelet activating factor, putative Inhibitor ABT-491 Family 22 62
D(4) dopamine receptor Ligand L-745,870 Family 30 205
CGMP-inhibited 3',5'-cyclic phosphodiesterase Inhibitor Olprin... 2 7
Herpes simplex virus type 1 thymidine kinase Inhibitor 9-(4-hy... 2 13
Steroid 17-alpha-hydroxylase/17,20 lyase and Aromatase Inhibit... 18 109
Serine/threonine-protein kinase B-raf Inhibitor 2-(benzylamino... 7 117
Epidermal growth factor receptor Ligand PD-158780 Family 98 89
Metabotropic glutamate receptor 5 Ligand 3-(4-pyridin-2-yl-imi... 6 5
Adenosine receptor A3 Ligand 1-benzyl-1h-1,3,4b,9-tetraaza-flu... 19 165
Telomerase reverse transcriptase Inhibitor HOE-33258 Family 10 33
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 5 45
Melanocortin receptor Ligand Ac-his-dnal(2)-arg-trp-nh2 Family 112 67
Adenosine receptor A1 and Adenosine receptor A3 Ligand VUF-850... 28 47
Melanocortin receptor 3 and Melanocortin receptor 4 Ligand Ac-... 38 60
Adenosine receptor A1 and Adenosine receptor A2a Ligand 2-phen... 8 11
Adenosine receptor A2b Ligand CVT-7124 Family 14 64
Dipeptidyl peptidase 4 Inhibitor (5-phenyl-3h-benzo[d]imidazol... 5 13
Fatty-acid amide hydrolase 1 Inhibitor JNJ-1661010 Family 3 14
RAF proto-oncogene serine/threonine-protein kinase Inhibitor L... 219 124
Adenosine receptor A2a Ligand (e,e)-8-(4-phenylbutadien-1-yl)c... 11 43
Bifunctional epoxide hydrolase 2 Inhibitor 6-amino-n-(2,4-dich... 10 116
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 24 79
Proto-oncogene tyrosine-protein kinase Src Inhibitor 5,7-diphe... 2 11
cGMP-specific 3',5'-cyclic phosphodiesterase Inhibitor SCH-577... 9 29
Herpes simplex virus type 1 thymidine kinase Inhibitor N2-(3-t... 1 2
RAC-gamma serine/threonine-protein kinase Inhibitor BMS-754807... 20 90
Serine/threonine-protein kinase B-raf Inhibitor Pyrazolo[1,5-a... 7 77
Cannabinoid receptor 1 Ligand 1-(4-chlorophenyl)-2-(2,4-dichlo... 18 41
Prothrombin inhibitor SureCN5855286 family 15 8
5-hydroxytryptamine receptor 1F and 5-hydroxytryptamine recept... 8 12
Prothrombin inhibitor SureCN5854779 family 4 9
Prothrombin inhibitor SureCN5856722 family 3 16
Tyrosine-protein kinase JAK3 and Tyrosine-protein kinase JAK2 ... 2 3
Sphingosine 1-phosphate receptor 1 ligand SureCN3029336 family 4 8
Orexin receptor type 2 and Orexin receptor type 1 ligand [(7R)... 10 10
Neuronal acetylcholine receptor subunit alpha-7 and Potassium ... 7 3
Orexin receptor type 2 and Orexin receptor type 1 ligand SureC... 2 3
Mu-type opioid receptor and Mu-type opioid receptor ligand Sur... 5 10
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 10 3
Cyclin-A2 and Cyclin-dependent kinase 2 inhibitor AGN-PC-07ZE3... 6 1
Adenosine receptor A1 ligand SureCN10614388 family 5 1
Adenosine receptor A1 ligand 8-(2-amino-4-nitrophenyl)-1,3-dim... 1 0
Tyrosine-protein kinase BTK and Tyrosine-protein kinase Lyn in... 7 7
Adenosine receptor A2a and Adenosine receptor A1 ligand SureCN... 2 1
Dipeptidyl peptidase 4 inhibitor AGN-PC-046QKE family 3 5
Platelet-activating factor receptor ligand SureCN9384429 family 11 3
Macrophage colony-stimulating factor 1 receptor ligand SureCN1... 28 9
Macrophage colony-stimulating factor 1 receptor and Cytochrome... 13 3
Platelet-activating factor receptor ligand 8-bromo-2-[4-(2-met... 2 2
Histamine H4 receptor ligand SureCN602132 family 1 8
Dipeptidyl peptidase 9 and Dipeptidyl peptidase 8 inhibitor Su... 16 5
Serine/threonine-protein kinase D1 and Polycystin-2 inhibitor ... 3 7
Dipeptidyl peptidase 8 and Dipeptidyl peptidase 4 inhibitor Su... 5 13
Melanin-concentrating hormone receptor 1 ligand AGN-PC-088XRP ... 2 10
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 7 10
Mitogen-activated protein kinase 14 inhibitor N-cyclopropyl-4-... 4 10
Cell division cycle 7-related protein kinase inhibitor pyrrolo... 4 10
Adenosine receptor A3 ligand N-(5-methyl-2-phenylpyrazolo[4,3-... 5 8
Mitogen-activated protein kinase 14 inhibitor AGN-PC-09M6OU fa... 8 7
Mitogen-activated protein kinase 14 inhibitor AGN-PC-069K8I fa... 12 3
C-C chemokine receptor type 5 ligand SureCN1573831 family 4 3
Peroxisome proliferator-activated receptor gamma ligand 1-[(4-... 7 29
Gastrin/cholecystokinin type B receptor and Cholecystokinin re... 3 3
Prelamin-A/C and Lethal(3)malignant brain tumor-like protein 1... 1 1
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 3 8
Renin and Cathepsin D inhibitor tert-butyl N-[(2S)-1-[[(2S)-1-... 2 2
Coagulation factor X and Trypsin-1 inhibitor 1-(3-carbamimidoy... 4 1
Prelamin-A/C and Cellular tumor antigen p53 inhibitor CHEMBL16... 1 7
Metabotropic glutamate receptor 2 ligand AGN-PC-09QJ9P family 2 7
Metabotropic glutamate receptor 2 ligand AGN-PC-01XRTW family 1 0
Prothrombin and Trypsin-1 inhibitor 2-[6-methyl-2-oxo-3-(2-pyr... 4 2
C-C chemokine receptor type 5 and Potassium voltage-gated chan... 21 32
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 9 3
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand AGN-P... 2 18
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand AGN-P... 2 1
Adenosine receptor A2a and Adenosine receptor A2b ligand SureC... 2 2
Corticosteroid 11-beta-dehydrogenase isozyme 1 and Nuclear rec... 9 6
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand AGN-P... 1 1
Cannabinoid receptor 2 ligand AGN-PC-0A9SMV family 1 1
Melanin-concentrating hormone receptor 1 ligand SureCN3334191 ... 4 7
Signal transducer and activator of transcription 6 inhibitor A... 3 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 2 1
MAP kinase-activated protein kinase 2 inhibitor AGN-PC-0A9QGC ... 14 0
Metabotropic glutamate receptor 5 ligand SureCN3866791 family 2 10
Mitogen-activated protein kinase 14 inhibitor N-ethyl-5-methyl... 17 3
Mitogen-activated protein kinase 14 and Mitogen-activated prot... 13 3
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 10 14
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 5 8
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 1 0
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 3 0
Renin inhibitor [2-[(3-fluoro-2-methylphenyl)methyl]-6-methyl-... 2 1
Coagulation factor X and Prothrombin inhibitor 2-carboxyindole... 2 8
Histamine H3 receptor and Potassium voltage-gated channel subf... 7 1
Coagulation factor X and Coagulation factor IX inhibitor pyraz... 11 0
Toll-like receptor 7 ligand 4-amino-1-[[6-[(2S)-2-(pyrrolidin-... 4 0
Coagulation factor X and Coagulation factor IX inhibitor pyraz... 6 1
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 2 0
Tyrosine-protein kinase JAK1 inhibitor CHEMBL2206623 family 10 11
MAP kinase-activated protein kinase 2 inhibitor 4-fluoro-N-[4-... 25 1
Ribosomal protein S6 kinase alpha-3 inhibitor N-(3-ethylimidaz... 2 2
3-phosphoinositide-dependent protein kinase 1 and RAC-alpha se... 10 4
Bifunctional epoxide hydrolase 2 inhibitor AGN-PC-0733AC family 7 29
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 5 4
Sodium- and chloride-dependent glycine transporter 1 and Sodiu... 4 8
Serine/threonine-protein kinase mTOR inhibitor 5-(2-amino-3H-b... 3 1
Dipeptidyl peptidase 4 and Potassium voltage-gated channel sub... 9 0
Dipeptidyl peptidase 4 and Cytochrome P450 3A4 inhibitor 6-[(3... 10 0
Aurora kinase B and Cyclin-dependent kinase 1 inhibitor 7-cycl... 3 16
Mitogen-activated protein kinase 14 inhibitor ethyl N-[4-[5-(m... 5 2
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 5 3
Cell division cycle 7-related protein kinase and Protein DBF4 ... 15 7
Mast/stem cell growth factor receptor Kit and Mitogen-activate... 4 2
Mast/stem cell growth factor receptor Kit and Receptor-type ty... 8 3
Insulin-like growth factor 1 receptor and Mitogen-activated pr... 3 4
Aurora kinase B and Aurora kinase A inhibitor 4-amino-N-[3-[[(... 5 3
Vascular endothelial growth factor receptor 2 ligand (3Z)-3-[5... 4 11
Platelet-derived growth factor receptor beta and Vascular endo... 5 12
Glycogen synthase kinase-3 beta inhibitor 2-(4-fluorophenyl)-N... 4 2
Aurora kinase A and Aurora kinase B inhibitor 4-amino-N-[4-(th... 1 1
Lysine--tRNA ligase inhibitor N-[2-(2-piperazin-1-ylpyridin-4-... 5 0
Somatostatin receptor type 3 ligand tert-butyl 4-[(3R)-3-(5-ph... 2 2
Aurora kinase A and Aurora kinase B inhibitor 4-fluoro-N-[4-[(... 6 1
Smoothened homolog inhibitor N-[4-methyl-3-(5-phenyl-1H-imidaz... 1 0
Tyrosine-protein kinase JAK2 inhibitor N-[3-(3-chlorophenyl)-1... 12 4
Tyrosine-protein kinase SYK and Potassium voltage-gated channe... 1 0
Serine/threonine-protein kinase pim-1 and Serine/threonine-pro... 17 0
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 3 1
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 5 6
Cathepsin K and Cathepsin S inhibitor 2-Cyano-pyrimidine, 17d ... 5 9
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand SureC... 6 5
cGMP-dependent 3',5'-cyclic phosphodiesterase and cAMP and cAM... 3 0
Melanocortin receptor 4 ligand AGN-PC-076AMO family 17 8
Tyrosine-protein kinase ABL1 and Abelson tyrosine-protein kina... 3 0
CGMP-dependent protein kinase inhibitor SureCN14561191 family 4 0
Dipeptidyl peptidase 4 inhibitor 2-[(3R)-3-aminopiperidin-1-yl... 3 4
Tyrosine-protein kinase SYK inhibitor N-tert-butyl-2-(6-fluoro... 5 1
Dipeptidyl peptidase 4 and Cytochrome P450 2D6 inhibitor (3R)-... 4 12
Serine/threonine-protein kinase mTOR inhibitor 1-ethyl-3-[4-[6... 4 1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 1 1
Adenosine receptor A3 and Adenosine receptor A1 ligand 2-pheny... 9 2
Histone deacetylase 1 inhibitor 1-methyl-N-[(1S)-7-oxo-1-(5-qu... 2 3
Cathepsin K inhibitor SureCN4138062 family 7 0
Cathepsin K and Cathepsin S inhibitor SureCN4138353 family 3 0
Tyrosine-protein kinase Lck and Proto-oncogene tyrosine-protei... 3 0
Dipeptidyl peptidase 4 inhibitor 2-(3-aminopiperidin-1-yl)-3-b... 4 1
Metabotropic glutamate receptor 2 ligand 8-(2,5-difluorophenyl... 6 2
Casein kinase II subunit alpha inhibitor CHEMBL401945 family 12 1
Metabotropic glutamate receptor 2 ligand 8-[2-(4-fluorophenyl)... 2 3
Mitogen-activated protein kinase 14 inhibitor 3-[(6-amino-1-ph... 9 2
Prothrombin inhibitor 2-[4-methyl-5-[[[2-[6-methyl-2-oxo-3-(2-... 1 0
Alpha-1A adrenergic receptor and Alpha-1B adrenergic receptor ... 3 0
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 2 22
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 2 0
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 3 0
Cyclin-dependent kinase 2 and Potassium voltage-gated channel ... 12 7
Cathepsin S and Cathepsin K inhibitor 2-cyano-N-[(2R)-1-phenyl... 2 0
Tyrosine-protein kinase SYK and Tyrosine-protein kinase ZAP-70... 3 0
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 4 0
Cholecystokinin receptor type A ligand SureCN3132309 family 11 0
Cyclin-dependent kinase 2 inhibitor SureCN3549598 family 3 1
Nitric oxide synthase, inducible and Nitric oxide synthase, br... 2 0
Melanin-concentrating hormone receptor 1 ligand SureCN3834858 ... 2 1
Tyrosine-protein kinase Lck inhibitor (3S)-3-[(1S)-1-[[4-(benz... 14 0
Sonic hedgehog protein and Cytochrome P450 2C9 inhibitor AGN-P... 1 0
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand SureC... 9 0
Transcription factor AP-1 and Nuclear factor NF-kappa-B p105 s... 2 4
DNA-(apurinic or apyrimidinic site) lyase and Retinal dehydrog... 1 2
Nitric oxide synthase, inducible and Nitric oxide synthase, br... 1 4
Tyrosine-protein kinase receptor TYRO3 ligand 3-amino-6-(1H-in... 2 3


CFAM Mol ID

External ID

Functional Category

Molecule Name


Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27525 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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