CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM5146
Family Name D(4) dopamine receptor and D(2) dopamine receptor ligand 1-(2-methoxyphenyl)-4-[(1-phenylpyrrol-3-yl)methyl]piperazine family
No. of Seeds 3 No. of Other Members 3
Family Centroid CFAMM00361713 Functional Category Bioactive
Superfamily D(2) dopamine receptor and Prelamin-A/C Binder Superfamily
Class Class 2208

Cousin Family NamesSeedsMembers
Beta adrenergic receptor ligand monosubstituted indole derivat... 14 475
Melatonin receptor type 1A Ligand Melatonin Family 20 988
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor indole... 28 2712
Phospholipase A2 Inhibitor Quinacrine Family 13 95
cGMP-specific 3',5'-cyclic phosphodiesterase Inhibitor Papaver... 53 741
Nicotinic acetylcholine receptor Ligand AZD0328 Family 11 97
Corticotropin-releasing factor receptor 1 Ligand Cp-316,311 Fa... 5 74
5-hydroxytryptamine receptor 1A and D(3) dopamine receptor Lig... 9 115
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 11 49
Grt 6005/06 family 4 22
PF-02545920 family 16 140
Nicotinic acetylcholine receptor alpha2 / alpha3 Ligand Ibogai... 3 21
Nicotinic acetylcholine receptor Ligand Dianicline Family 6 13
72 kDa type IV collagenase and Matrix metalloproteinase-9 Inhi... 37 265
Protein kinase C theta type Inhibitor 4-(1h-indol-5-yloxy)-5-s... 21 194
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 13 22
Hemoglobin subunit alpha Inhibitor 2-[(2-methoxy-5-methylpheno... 5 48
Platelet-derived growth factor receptor alpha and Platelet-der... 2 9
Platelet-derived growth factor receptor alpha and Platelet-der... 2 14
5-hydroxytryptamine receptor 2A Ligand [2-(6-methoxy-indol-1-y... 2 10
Oestrogen receptor and Estrogen receptor beta Ligand Pipendoxi... 11 48
Alpha-1A adrenergic receptor Ligand RS-17053 Family 9 6
Adenosine receptor A3 Ligand 4-methoxy-2-phenyl-2h-pyrazolo[4,... 9 49
D(2) dopamine receptor Ligand SLV-314 Family 19 69
DNA-dependent protein kinase catalytic subunit Inhibitor 8-(1h... 3 85
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 4 35
RAC-gamma serine/threonine-protein kinase Inhibitor A-443654 F... 67 59
Metabotropic glutamate receptor 5 Ligand 2-methyl-6-((3-methox... 3 9
5-hydroxytryptamine receptor 2C Ligand N-(6-phenoxypyridin-3-y... 9 69
5-hydroxytryptamine receptor 2A and Amine oxidase [flavin-cont... 4 32
Adenosine receptor A1 and Adenosine receptor A2a Ligand SB-298... 53 320
5-hydroxytryptamine receptor 2A and Alpha-2A adrenergic recept... 4 29
Translocator protein Inhibitor 4-methoxy-5-phenyl-6-thia-10b-a... 7 32
5-hydroxytryptamine receptor 1A and Alpha-1A adrenergic recept... 28 24
Prostaglandin G/H synthase 2 Inhibitor L-761000 Family 8 44
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 17 49
Arachidonate 5-lipoxygenase Inhibitor TZI-41127 Family 7 34
Metabotropic glutamate receptor 5 Ligand 3-methoxy-5-(2-methyl... 7 27
Metabotropic glutamate receptor 5 Ligand 3-methoxy-5-(1,5-naph... 4 20
Metabotropic glutamate receptor 5 Ligand 7-(3,5-dimethoxypheny... 2 7
Cannabinoid receptor 1 Ligand 1-(2-morpholinoethyl)-1h-indol-3... 8 46
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 3 16
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 17 69
Histamine H3 receptor and Potassium voltage-gated channel subf... 1 2
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 3 3
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 2 6
Translocator protein inhibitor SureCN13502542 family 20 2
Corticotropin-releasing factor receptor 1 ligand AGN-PC-074YQD... 1 5
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 2 1
Smoothened homolog inhibitor AGN-PC-088VBV family 1 2
Neuropeptide Y receptor type 1 ligand SureCN7959923 family 1 6
Leukotriene B4 receptor 1 and Leukotriene B4 receptor 2 ligand... 2 5
D(3) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 10 50
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 4 6
Melanin-concentrating hormone receptor 1 and Cytochrome P450 3... 8 2
Prelamin-A/C inhibitor 1-[(3,4-dimethoxyphenethyl)amino]-3-(1H... 1 2
Cellular tumor antigen p53 and DNA polymerase beta inhibitor C... 1 15
Translocator protein inhibitor (4-chloro-6-phenylpyrrolo[2,1-d... 2 0
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 2 15
Cellular tumor antigen p53 inhibitor CHEMBL1401545 family 1 25
D(2) dopamine receptor and D(4) dopamine receptor ligand N-[3-... 6 22
DNA-(apurinic or apyrimidinic site) lyase and Ras-related prot... 1 6
Coagulation factor X and Anionic trypsin-2 inhibitor AGN-PC-07... 1 1
Prelamin-A/C and Nuclear receptor ROR-gamma ligand CHEMBL15681... 1 5
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 2 4
D(4) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 3 6
Potassium voltage-gated channel subfamily H member 2 and Sodiu... 2 13
5-hydroxytryptamine receptor 6 ligand 1-[9-(benzenesulfonyl)-6... 11 2
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 2 1
Translocator protein inhibitor 2-fluoro-N-[(2-methoxyphenyl)me... 8 27
Sodium-dependent serotonin transporter inhibitor SureCN7536104... 6 2
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 3 0
D(2) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 3 0
Sodium-dependent serotonin transporter inhibitor AGN-PC-075G9A... 3 2
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 2 2
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 2 3
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 3 0
Translocator protein inhibitor (4S)-N,N-diethyl-9-(2-fluoranyl... 9 10
Serine/threonine-protein kinase B-raf inhibitor pyrrole-based ... 2 0
RAC-alpha serine/threonine-protein kinase and cAMP-dependent p... 3 0
5-hydroxytryptamine receptor 1A and Alpha-1D adrenergic recept... 3 0
Histone deacetylase 6 and Histone deacetylase 1 inhibitor N-hy... 3 2
Substance-P receptor ligand 1-[4-(2-methoxyphenyl)piperazin-1-... 11 12
D(3) dopamine receptor and D(2) dopamine receptor ligand Piper... 3 14
Cathepsin K inhibitor (1R,2R)-N-(1-cyanocyclopropyl)-2-(6-meth... 3 0
Substance-P receptor ligand AGN-PC-01VLKE family 9 11
Neuronal acetylcholine receptor subunit beta-2 and Neuronal ac... 5 0
5-hydroxytryptamine receptor 4 and 5-hydroxytryptamine recepto... 5 14
5-hydroxytryptamine receptor 4 and 5-hydroxytryptamine recepto... 4 4
Histamine H3 receptor and D(3) dopamine receptor ligand BODILI... 1 0
D(3) dopamine receptor and D(2) dopamine receptor ligand 4-[1-... 1 0
Egl nine homolog 1 inhibitor 2-(2-methoxy-4-phenylphenyl)-8-[(... 1 0
Corticotropin-releasing factor receptor 1 ligand 3-ethyl-1-(2-... 5 15
C5a anaphylatoxin chemotactic receptor 1 ligand 2-(2,6-diethyl... 3 5
D(2) dopamine receptor ligand SureCN10575660 family 1 1
Alpha-1D adrenergic receptor and Alpha-1B adrenergic receptor ... 2 1
Sigma non-opioid intracellular receptor 1 ligand 1'-[4-[1-(4-f... 2 0
D(3) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 2 0
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 23 5
Protein kinase C theta type and Protein kinase C delta type in... 10 7
Sodium-dependent serotonin transporter and D(2) dopamine recep... 4 0
Nischarin inhibitor SureCN7810370 family 1 0
Glutamate receptor ionotropic, NMDA 1 and Glutamate receptor i... 1 1
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 1 1
Dipeptidyl peptidase 4 inhibitor 2-[3-(aminomethyl)-4-(4-fluor... 3 0
Corticotropin-releasing factor receptor 1 ligand 2-[2,6-dimeth... 10 10
Corticotropin-releasing factor receptor 1 ligand 2-[2,6-dimeth... 9 0
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 3 3
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 3 4
Insulin-like growth factor 1 receptor ligand IGF-1R Inhibitor ... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00361713 CHEMBL28321 Bioactive 1-(2-methoxyphenyl)-4-[(1-phenylpyrrol-3-yl)methyl]piperazine
CFAMM00361712 CHEMBL146535 Bioactive AGN-PC-075QMK

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

44499 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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