CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM516
Family Name 5-hydroxytryptamine receptor 6 and 5-hydroxytryptamine receptor 2B ligand CHEMBL2172186 family
No. of Seeds 13 No. of Other Members 100
Family Centroid CFAMM00312617 Functional Category Bioactive
Superfamily 5-hydroxytryptamine receptor 6 and 5-hydroxytryptamine receptor 2B Binder Superfamily
Class Class 3175

Cousin Family NamesSeedsMembers
Omega 1 Benzodiazepine receptor Ligand Zaleplon Family 6 589
Mast/stem cell growth factor receptor Kit and Vascular endothe... 6 34
Hepatocyte growth factor receptor Ligand SGX523 Family 1 15
Tyrosine-protein kinase Lck and Aurora kinase B Inhibitor VX-6... 28 56
Aurora kinase B and Aurora kinase C Inhibitor GSK1070916 Family 53 580
Corticotropin-releasing factor receptor 1 Ligand R121919 Family 26 84
Interleukin-1 receptor type 1 and Mitogen-activated protein ki... 7 151
Vascular endothelial growth factor receptor 1 and Vascular end... 6 23
Hepatocyte growth factor receptor Ligand 3-(phenylsulfonyl)-1h... 17 59
5-hydroxytryptamine receptor 6 ligand AGN-PC-0BIUF2 family 25 11
5-hydroxytryptamine receptor 6 and 5-hydroxytryptamine recepto... 2 0
5-hydroxytryptamine receptor 6 ligand AGN-PC-03P3TZ family 6 88
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 3 2
Adenosine receptor A1 and Adenosine receptor A2a ligand 2-(4-a... 8 11
Serine/threonine-protein kinase pim-1 and Serine/threonine-pro... 7 9
5-hydroxytryptamine receptor 6 ligand SureCN3399354 family 7 3
5-hydroxytryptamine receptor 6 ligand [3-(benzenesulfonyl)-5-m... 7 1
5-hydroxytryptamine receptor 6 ligand 3-(3-chloro-4-fluorophen... 1 2
5-hydroxytryptamine receptor 6 ligand 3-(benzenesulfonyl)-N,5-... 4 1
5-hydroxytryptamine receptor 6 ligand 3-(3-chlorophenyl)sulfon... 6 0
Tyrosine-protein kinase JAK2 inhibitor AGN-PC-07CBUP family 2 3
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 3 5
Glucose-dependent insulinotropic receptor ligand 4-({Ethyl-[1-... 6 12
Glucose-dependent insulinotropic receptor ligand 4-[1-(4-Metha... 9 22
Cyclin-dependent kinase 2 and Glycogen synthase kinase-3 beta ... 2 3
Cyclin-dependent kinase 2 and Glycogen synthase kinase-3 beta ... 3 1
Nociceptin receptor and Potassium voltage-gated channel subfam... 10 1
Receptor-type tyrosine-protein kinase FLT3 and Aurora kinase A... 3 5
Tyrosine-protein kinase JAK2 inhibitor N-tert-butyl-3-[2-[3-fl... 4 14
Aurora kinase A and Cyclin-dependent kinase 1 inhibitor N-[4-[... 12 2
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 3 11
Tyrosine-protein kinase JAK2 and Focal adhesion kinase 1 inhib... 11 3
Mitogen-activated protein kinase 14 inhibitor 1-(5-tert-butyl-... 2 0
Aurora kinase B and Vascular endothelial growth factor recepto... 1 2
Tyrosine-protein kinase Mer and Tyrosine-protein kinase recept... 5 3
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 7 15
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 1 0
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK3 ... 14 1
Casein kinase II subunit alpha inhibitor 7-(cyclopropylamino)-... 1 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 1 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 2 2
Serine/threonine-protein kinase SMG1 and Cyclin-dependent kina... 3 1
Tyrosine-protein kinase JAK2 inhibitor AGN-PC-0CSEAG family 2 1
Cathepsin K and Cathepsin S inhibitor SureCN4138353 family 3 0
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 2 0
5-hydroxytryptamine receptor 6 ligand 8-(1-pyrrolidin-3-ylpyrr... 1 0
Adenosine receptor A2a and Adenosine receptor A2b ligand SureC... 4 5
Cyclin-dependent kinase 2 inhibitor Imidazo[1,2-b]pyridazine d... 2 1
Aurora kinase A and Glycogen synthase kinase-3 beta inhibitor ... 2 0
Mitogen-activated protein kinase 14 inhibitor AGN-PC-07R77D fa... 2 7
Muscarinic acetylcholine receptor M1 and Cytochrome P450 2C9 l... 2 5
Tyrosine-protein kinase ABL1 and Proto-oncogene tyrosine-prote... 2 26
Prostaglandin G/H synthase 2 and Cyclooxygenase 2 inhibitor Su... 2 6
Cyclooxygenase 2 and Prostaglandin G/H synthase 1 inhibitor Su... 2 1
Glucocorticoid receptor ligand N-ethyl-4-fluoro-N-[3,3,3-trifl... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00312620 CHEMBL2172183 Bioactive CHEMBL2172183
CFAMM00312660 CHEMBL1082763 Bioactive AGN-PC-071SNC
CFAMM00312666 CHEMBL1091206 Bioactive SureCN8022984
CFAMM00312659 CHEMBL1082761 Bioactive AGN-PC-07ZZRP
CFAMM00312665 CHEMBL1091208 Bioactive AGN-PC-07ZCMJ
CFAMM00312618 CHEMBL2172185 Bioactive CHEMBL2172185
CFAMM00312617 CHEMBL2172186 Bioactive CHEMBL2172186
CFAMM00312685 CHEMBL1642114 Bioactive CHEMBL1642114
CFAMM00312635 CHEMBL2172192 Bioactive CHEMBL2172192
CFAMM00312662 CHEMBL1084244 Bioactive AGN-PC-07ZFUB
CFAMM00312634 CHEMBL2172191 Bioactive CHEMBL2172191
CFAMM00312574 CHEMBL1083654 Bioactive SureCN8040217

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

23192 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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