CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM5175
Family Name 5-hydroxytryptamine receptor 1A and Alpha-1B adrenergic receptor ligand (1S,5R)-8-[[(3S)-5-ethoxy-2,3-dihydro-1,4-benzodioxin-3-yl]methyl]-3-phenyl-8-azabicyclo[3.2.1]octan-3-ol family
No. of Seeds 7 No. of Other Members 4
Family Centroid CFAMM00361872 Functional Category Bioactive
Superfamily Acolbifene Superfamily
Class Class 1273

Cousin Family NamesSeedsMembers
Voltage-dependent T-type calcium channel subunit alpha-1I liga... 5 209
Noradrenergic re-uptake Inhibitor Reboxetine Family 26 206
Beta-1 adrenergic receptor Ligand Nebivolol Family 5 22
5-hydroxytryptamine receptor 1A Ligand MN-305 Family 12 26
Vernakalant family 1 1
Acolbifene family 10 115
Arachidonate 5-lipoxygenase Inhibitor Bw A360C Family 12 8
Histamine H3 receptor Ligand UCL-2138 Family 23 172
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 25 50
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 5 11
5-hydroxytryptamine receptor 7 Ligand (r)-8-phenyl-n,n-dipropy... 9 14
Sodium-dependent dopamine transporter Inhibitor Secocularidine... 3 9
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 4 10
5-hydroxytryptamine receptor 1A and Alpha-1D adrenergic recept... 2 2
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 6 5
Alpha-1A adrenergic receptor and 5-hydroxytryptamine receptor ... 1 0
5-hydroxytryptamine receptor 1A and Alpha-1B adrenergic recept... 1 0
Histamine H3 receptor ligand cyclohexyl-[4-(3-piperidin-1-ylpr... 4 1
Histamine H3 receptor and Sodium-dependent serotonin transport... 3 6
D(2) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 1 7
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 1 2
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 2 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00361871 CHEMBL357321 Bioactive 8-[[(3S)-5-methoxy-2,3-dihydro-1,4-benzodioxin-3-yl]methyl]-3-naphthalen-2-yl-8-azabicyclo[3.2.1]oct-3-ene
CFAMM00361870 CHEMBL149888 Bioactive (1S,5R)-8-[[(3S)-5-ethoxy-2,3-dihydro-1,4-benzodioxin-3-yl]methyl]-3-[3-(trifluoromethyl)phenyl]-8-azabicyclo[3.2.1]octan-3-ol
CFAMM00361869 CHEMBL435279 Bioactive (1S,5R)-8-[[(3S)-5-methoxy-2,3-dihydro-1,4-benzodioxin-3-yl]methyl]-3-[3-(trifluoromethyl)phenyl]-8-azabicyclo[3.2.1]octan-3-ol
CFAMM00361872 CHEMBL147477 Bioactive (1S,5R)-8-[[(3S)-5-ethoxy-2,3-dihydro-1,4-benzodioxin-3-yl]methyl]-3-phenyl-8-azabicyclo[3.2.1]octan-3-ol
CFAMM00361865 CHEMBL151266 Bioactive (1S,5R)-8-[[(3S)-5-methoxy-2,3-dihydro-1,4-benzodioxin-3-yl]methyl]-3-phenyl-8-azabicyclo[3.2.1]octan-3-ol

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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