CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM5195
Family Name Dihydrofolate reductase inhibitor 2-[[4-carboxy-4-[[4-[(2,4-diaminoquinazolin-6-yl)methylamino]benzoyl]amino]butyl]carbamoyl]benzoic acid family
No. of Seeds 3 No. of Other Members 1
Family Centroid CFAMM00362121 Functional Category Bioactive
Superfamily Dihydrofolate reductase and Egl nine homolog 1 Binder Superfamily
Class Class 1253

Cousin Family NamesSeedsMembers
Prostaglandin G/H synthase 2 Inhibitor Niflumic Acid Family 7 119
Peptide deformylase, mitochondrial inhibitor folic acid analog... 59 98
Aurora kinase A Inhibitor MLN8054 Family 2 5
Integrin alpha-V and Integrin beta-3 Inhibitor SB-223245 Family 27 36
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 19 103
Mitogen-activated protein kinase 8 Inhibitor 2-(2-phenoxypyrim... 12 30
Thymidylate synthase inhibitor (2S)-2-[[4-[(2-methyl-4-oxo-1,6... 15 107
Bifunctional dihydrofolate reductase-thymidylate synthase and ... 6 11
Thymidylate synthase inhibitor AC1LABAB family 14 3
Thymidylate synthase inhibitor (2R)-2-[[(4S)-4-carboxy-4-[[4-[... 55 43
Trifunctional purine biosynthetic protein adenosine-3 inhibito... 4 11
Thymidylate synthase inhibitor AC1LAB82 family 17 0
Thymidylate synthase inhibitor AC1LAB7Z family 8 3
Type-1A angiotensin II receptor and Type-1B angiotensin II rec... 2 9
Dihydrofolate reductase and Thymidylate synthase inhibitor 2-[... 10 5
Dihydrofolate reductase inhibitor AGN-PC-075RRH family 2 3
Dipeptidyl peptidase 4 inhibitor 3-[6-[(3R,4S)-3-amino-4-(2,4,... 3 7
Thymidylate synthase inhibitor (2S)-2-[[(4S)-4-carboxy-4-[[(4S... 7 11
Type-1 angiotensin II receptor and Type-2 angiotensin II recep... 4 29
Dipeptidyl peptidase 4 inhibitor 2-[(3R)-3-aminopiperidin-1-yl... 7 15
Aurora kinase A and Cyclin-dependent kinase 4 inhibitor 2-[3-[... 1 0
Aurora kinase A inhibitor Bisanilinopyrimidine, 6i family 1 0
Trifunctional purine biosynthetic protein adenosine-3 inhibito... 4 1
Tyrosine-protein kinase JAK2 inhibitor 4-[[8-(1-propan-2-ylpyr... 5 6
Folylpolyglutamate synthase, mitochondrial and Dihydrofolate r... 3 0
Dihydrofolate reductase inhibitor AGN-PC-073PND family 4 0
Dihydrofolate reductase inhibitor 2-[[4-[2-(2-amino-4-oxo-1,5,... 2 0
Type-1A angiotensin II receptor and Type-1B angiotensin II rec... 3 6
Thymidylate synthase inhibitor SureCN6446340 family 2 1
Cationic trypsin and Prothrombin inhibitor 2-ketobenzothiazole... 1 3
Type-1 angiotensin II receptor ligand 2-ethyl-4-[[4-[2-(2H-tet... 2 0
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 2 0
Trifunctional purine biosynthetic protein adenosine-3 inhibito... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00362122 CHEMBL146917 Bioactive 2-[[4-carboxy-4-[[4-[(2,4-diamino-5-chloroquinazolin-6-yl)methylamino]benzoyl]amino]butyl]carbamoyl]benzoic acid
CFAMM00362121 CHEMBL297088 Bioactive 2-[[4-carboxy-4-[[4-[(2,4-diaminoquinazolin-6-yl)methylamino]benzoyl]amino]butyl]carbamoyl]benzoic acid
CFAMM00362120 CHEMBL149218 Bioactive AGN-PC-009X7P

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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