CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

Family Name Rho-associated protein kinase 2 inhibitor N-(7-chloro-1-oxo-2H-isoquinolin-6-yl)-4-phenylpyrrolidine-3-carboxamide family
No. of Seeds 13 No. of Other Members 42
Family Centroid CFAMM00312781 Functional Category Bioactive
Superfamily Apolipoprotein B-100 and Melanin-concentrating hormone receptor 1 Binder Superfamily
Class Class 3113

Cousin Family NamesSeedsMembers
Potassium voltage-gated channel subfamily A member 5 Ligand S-... 34 206
Vasopressin V1a receptor and Vasopressin V2 receptor Ligand OP... 12 94
Voltage-dependent T-type calcium channel subunit alpha-1I Liga... 7 35
Phospholipase D1 Inhibitor Halopemide Family 17 111
Metabotropic glutamate receptor 5 Ligand N-(3-acetamidophenyl)... 4 20
Vasopressin V2 receptor ligand [2-chloro-4-(prop-2-enylamino)p... 3 14
D(3) dopamine receptor and Alpha-1B adrenergic receptor ligand... 11 8
Cellular tumor antigen p53 and Inositol monophosphatase 1 inhi... 1 12
Prelamin-A/C and Lysine-specific demethylase 4E inhibitor 4-(4... 2 3
Mitogen-activated protein kinase 14 inhibitor 4-chloro-N-cyclo... 2 0
Melanin-concentrating hormone receptor 1 and Melanin-concentra... 8 1
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A ... 2 2
B1 bradykinin receptor ligand 4-(4-methyl-1-oxophthalazin-2-yl... 5 27
Serine/threonine-protein kinase B-raf inhibitor N-[3-[(6-chlor... 3 5
Substance-P receptor and Substance-K receptor ligand AGN-PC-07... 5 2
Coagulation factor X and Prothrombin inhibitor SureCN14502287 ... 16 5
P2X purinoceptor 7 inhibitor 2-[3-fluoro-4-(trifluoromethyl)ph... 3 0
C-C chemokine receptor type 1 ligand 3-[2-(carbamoylamino)phen... 2 1
Melanin-concentrating hormone receptor 1 ligand SureCN5517533 ... 2 3
C-C chemokine receptor type 2 ligand 2-amino-N-[2-[[(3R)-1-[(3... 2 4
Coagulation factor X inhibitor N-(4-chlorophenyl)-2-[[4-(2-oxo... 2 0
Apolipoprotein B-100 and Microsomal triglyceride transfer prot... 3 0
Sodium-dependent noradrenaline transporter inhibitor AGN-PC-07... 1 1
Vascular endothelial growth factor receptor 2 ligand isoindoli... 1 0
P2X purinoceptor 7 inhibitor 2-[4-chloro-3-(trifluoromethyl)ph... 4 1
P2X purinoceptor 7 inhibitor (2S)-2-[5-[[2-(1-adamantyl)acetyl... 1 0
C-C chemokine receptor type 5 ligand AC1MHPA7 family 2 2


External ID

Functional Category

Molecule Name

CFAMM00312776 CHEMBL1084110 Bioactive N-(7-chloro-1-oxo-2H-isoquinolin-6-yl)-4-(4-fluorophenyl)pyrrolidine-3-carboxamide
CFAMM00312769 CHEMBL1222573 Bioactive SureCN14130851
CFAMM00312781 CHEMBL1084597 Bioactive N-(7-chloro-1-oxo-2H-isoquinolin-6-yl)-4-phenylpyrrolidine-3-carboxamide
CFAMM00312810 CHEMBL1082821 Bioactive (3S,4R)-N-(7-chloro-1-oxo-2H-isoquinolin-6-yl)-4-(4-chlorophenyl)pyrrolidine-3-carboxamide
CFAMM00312787 CHEMBL1085773 Bioactive N-(7-chloro-1-oxo-2H-isoquinolin-6-yl)-4-(3-propan-2-ylphenyl)pyrrolidine-3-carboxamide
CFAMM00312774 CHEMBL1084051 Bioactive N-(7-chloro-1-oxo-2H-isoquinolin-6-yl)-4-(3-ethylphenyl)pyrrolidine-3-carboxamide
CFAMM00312802 CHEMBL1083749 Bioactive N-(7-chloro-1-oxo-2H-isoquinolin-6-yl)-4-(3-methylphenyl)pyrrolidine-3-carboxamide
CFAMM00312800 CHEMBL1083747 Bioactive 4-(3-bromophenyl)-N-(7-chloro-1-oxo-2H-isoquinolin-6-yl)pyrrolidine-3-carboxamide
CFAMM00312755 CHEMBL1084653 Bioactive 4-(4-bromophenyl)-N-(7-chloro-1-oxo-2H-isoquinolin-6-yl)pyrrolidine-3-carboxamide
CFAMM00312763 CHEMBL1084324 Bioactive N-(7-chloro-1-oxo-2H-isoquinolin-6-yl)-4-phenylpiperidine-3-carboxamide
CFAMM00312760 CHEMBL1083276 Bioactive N-(7-chloro-1-oxo-2H-isoquinolin-6-yl)-4-[3-(trifluoromethyl)phenyl]pyrrolidine-3-carboxamide
CFAMM00312770 CHEMBL1083799 Bioactive N-(7-chloro-1-oxo-2H-isoquinolin-6-yl)-4-(2,4-dichlorophenyl)pyrrolidine-3-carboxamide
CFAMM00312783 CHEMBL1082819 Bioactive N-(7-chloro-1-oxo-2H-isoquinolin-6-yl)-4-(4-chlorophenyl)pyrrolidine-3-carboxamide

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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