CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM5203
Family Name Dihydrofolate reductase and Bifunctional dihydrofolate reductase-thymidylate synthase inhibitor AC1LAKT7 family
No. of Seeds 5 No. of Other Members 0
Family Centroid CFAMM00189949 Functional Category Bioactive
Superfamily Metabotropic glutamate receptor 5 and Sodium channel protein type 1 subunit alpha Binder Superfamily
Class Class 2568

Cousin Family NamesSeedsMembers
5-hydroxytryptamine receptor 2C ligand Tetracyclic antidepress... 14 498
Glutamate dehydrogenase inhibitor quinoline derivative Chloroq... 7 189
Peptide deformylase, mitochondrial Inhibitor Pyrimethamine Family 10 145
Metabotropic glutamate receptor 5 Ligand ADX-48621 Family 15 444
C-X-C chemokine receptor type 4 Ligand AMD-070 Family 12 800
Transient receptor potential cation channel subfamily V member... 16 295
Transient receptor potential cation channel subfamily V member... 15 457
Fibroblast growth factor receptor 2 and Fibroblast growth fact... 11 86
Cannabinoid receptor 1 Ligand CP-945598 Family 18 173
Reverse transcriptase Inhibitor Dapivirine Family 5 72
Translocator protein Inhibitor Emapunil Family 7 89
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 14 234
Adenosine receptor A1 Ligand SLV320 Family 6 79
Aurora kinase B and Aurora kinase C Inhibitor GSK1070916 Family 53 580
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 35 270
RAC-gamma serine/threonine-protein kinase Inhibitor AZD5363 Fa... 35 69
Histone deacetylase 6 Inhibitor ACY-1215 Family 10 230
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 8 55
Bacterial outer membrane Inhibitor HKI-9924129 Family 19 85
D(4) dopamine receptor Ligand L-745,870 Family 30 205
Corticotropin-releasing factor receptor 1 Ligand R121919 Family 26 84
Epidermal growth factor receptor and Receptor tyrosine-protein... 11 138
Beta-secretase 1 Inhibitor 6-[2-(1h-indol-6-yl)ethyl]pyridin-2... 10 43
Beta-secretase 1 Inhibitor N~3~-(3-pyridin-3-ylbenzyl)pyridine... 31 66
Adenosine receptor A3 Ligand 2,6-bis(4-chlorophenyl)-9h-purine... 4 12
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 4 32
Steroid 17-alpha-hydroxylase/17,20 lyase and Aromatase Inhibit... 18 109
Vascular endothelial growth factor receptor 1 and Vascular end... 6 23
Epidermal growth factor receptor Ligand PD-158780 Family 98 89
Epidermal growth factor receptor Ligand N*4*-(3-bromo-phenyl)-... 7 11
Cyclin-dependent kinase 4 Inhibitor 1-pyridin-2-yl-3-quinolin-... 2 5
Scytalone dehydratase Inhibitor Isoquinolin-1-yl-(3-phenyl-pro... 4 9
Epidermal growth factor receptor Ligand Benzo[g]quinazolin-4-y... 5 3
Epidermal growth factor receptor Ligand (3-bromo-phenyl)-quina... 7 5
Metabotropic glutamate receptor 5 Ligand 3-(4-pyridin-2-yl-imi... 6 5
Cyclin-dependent kinase 1 Inhibitor CGP-60474 Family 14 103
Mitogen-activated protein kinase 3 and RAF proto-oncogene seri... 8 5
Epidermal growth factor receptor Ligand N4-(3-chlorophenyl)qui... 7 39
RAC-gamma serine/threonine-protein kinase and Rho-associated p... 16 46
Metabotropic glutamate receptor 5 Ligand 2-m-tolyl-1,8-naphthy... 7 11
Adenosine receptor A3 Ligand 2-(5-chloro-1h-benzo[d]imidazol-2... 7 51
Adenosine receptor A3 Ligand 1-(2-(diethylamino)quinazolin-4-y... 2 9
Mitogen-activated protein kinase 14 and Tyrosine-protein kinas... 3 9
Proto-oncogene tyrosine-protein kinase Src Inhibitor BMS-27970... 41 59
Fatty-acid amide hydrolase 1 Inhibitor JNJ-1661010 Family 3 14
Macrophage migration inhibitory factor Inhibitor 4-iodo-6-phen... 5 4
Oestrogen receptor Ligand 4-benzyl-2,6-diisobutylamino-pyrimid... 5 37
Histamine H4 receptor Ligand A-943931 Family 14 11
RAF proto-oncogene serine/threonine-protein kinase Inhibitor L... 219 124
Sodium channel protein type 1 subunit alpha and Sodium channel... 1 2
Glycogen synthase kinase-3 beta Inhibitor CHIR-98023 Family 5 6
Macrophage migration inhibitory factor Inhibitor 1-(2-chloroph... 2 22
Proto-oncogene tyrosine-protein kinase Src Inhibitor CGP-62464... 3 10
Sodium-dependent serotonin transporter Inhibitor 6-chloro-2-pi... 5 35
Sodium channel protein type 1 subunit alpha and Sodium channel... 10 14
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 3 63
Metabotropic glutamate receptor 5 Ligand 2-(3,5-dichlorophenyl... 2 3
Metabotropic glutamate receptor 5 Ligand 2-(3-bromophenyl)-7-m... 3 1
Metabotropic glutamate receptor 5 Ligand 5-(2-(3-chlorophenyl)... 2 13
Acetylcholinesterase Inhibitor N-benzyl-2-morpholinopyrimidin-... 6 16
Acetylcholinesterase and Cholinesterase Inhibitor Huprine-tacr... 62 27
Tyrosine-protein kinase Lck and Tyrosine-protein kinase HCK in... 8 7
Dihydrofolate reductase and Bifunctional dihydrofolate reducta... 3 9
5-hydroxytryptamine receptor 1A and D(1A) dopamine receptor li... 2 3
Aurora kinase B inhibitor AGN-PC-07ZZ0Y family 2 12
Tyrosine-protein kinase BTK and Tyrosine-protein kinase Lyn in... 7 7
Leukocyte tyrosine kinase receptor and ALK tyrosine kinase rec... 3 0
RAF proto-oncogene serine/threonine-protein kinase and Serine/... 3 5
Adenosine kinase inhibitor 5-(4-chlorophenyl)-6-[2-(6-morpholi... 8 8
Tyrosine-protein kinase ABL1 and Mitogen-activated protein kin... 1 3
Aurora kinase A and Aurora kinase B inhibitor 3uol family 6 5
D(2) dopamine receptor and D(3) dopamine receptor ligand AGN-P... 1 0
RAC-alpha serine/threonine-protein kinase inhibitor (2S)-3-ami... 2 0
Serine/threonine-protein kinase pim-1 and Serine/threonine-pro... 7 9
Epidermal growth factor receptor ligand N-[4-(3-chloro-4-fluor... 8 4
Dihydrofolate reductase inhibitor AC1LAKQL family 3 1
Prelamin-A/C inhibitor CHEMBL1472945 family 1 32
Dihydrofolate reductase inhibitor AC1LAKWV family 2 0
Dihydrofolate reductase inhibitor 6-[[(4-chloronaphthalen-1-yl... 2 1
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand AGN-P... 5 0
Receptor tyrosine-protein kinase erbB-2 and Epidermal growth f... 3 7
Signal transducer and activator of transcription 6 inhibitor A... 3 0
Nociceptin receptor and Potassium voltage-gated channel subfam... 10 1
Mu-type opioid receptor and Kappa-type opioid receptor ligand ... 3 0
Cyclin-dependent kinase 2 and Glycogen synthase kinase-3 beta ... 3 3
Glycogen synthase kinase-3 beta and Cyclin-dependent kinase 4 ... 2 1
Serine/threonine-protein kinase pim-2 and Serine/threonine-pro... 9 2
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 2 0
Mitogen-activated protein kinase 14 inhibitor 4-(2-chloropheny... 4 0
Vascular endothelial growth factor receptor 2 and Fibroblast g... 5 2
Aurora kinase A and Aurora kinase B inhibitor 2-[[5-chloro-2-[... 3 7
Cell division cycle 7-related protein kinase and Protein DBF4 ... 15 7
Cell division cycle 7-related protein kinase and Dual specific... 3 1
Protein kinase C theta type and Leucine-rich repeat serine/thr... 1 1
Transient receptor potential cation channel subfamily V member... 4 0
C-C chemokine receptor type 4 ligand [4-[4-[(2,4-dichloropheny... 4 4
Epidermal growth factor receptor and Receptor tyrosine-protein... 8 4
Epidermal growth factor receptor ligand N-[3-[3-methyl-7-[4-(4... 2 1
Cannabinoid receptor 2 ligand 8-(2-chlorophenyl)-9-cyclopropyl... 4 5
Mitogen-activated protein kinase 14 inhibitor pyrimido-pyrimid... 15 0
D(4) dopamine receptor and D(3) dopamine receptor ligand AGN-P... 2 0
Tyrosine-protein kinase Lck inhibitor AGN-PC-0762YG family 2 2
Serine/threonine-protein kinase SMG1 and Cyclin-dependent kina... 3 1
Beta-secretase 1 and Potassium voltage-gated channel subfamily... 3 4
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand N-[1-... 5 3
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 7 4
Receptor-type tyrosine-protein kinase FLT3 and Aurora kinase A... 2 0
Adenosine kinase inhibitor 4-[2-[5-(4-chlorophenyl)-6-piperazi... 3 1
Dihydrofolate reductase and Bifunctional dihydrofolate reducta... 3 5
Fatty-acid amide hydrolase 1 inhibitor 4-(3-phenyl-1,2,4-thiad... 2 1
Cholinesterase inhibitor 4-[4,5-diphenyl-1-[7-(1,2,3,4-tetrahy... 2 1
Mitogen-activated protein kinase 10 inhibitor CYCLOPROPYL-{4-[... 2 1
Nociceptin receptor and Potassium voltage-gated channel subfam... 5 2
LIM domain kinase 2 inhibitor (2S)-N-cyano-N'-(3-cyanophenyl)-... 4 0
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 14 14
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 4 3
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 1 0
Adenosine kinase inhibitor SureCN8248615 family 2 3
Corticotropin-releasing factor receptor 1 ligand AGN-PC-00FF1P... 1 3
Proto-oncogene tyrosine-protein kinase Src and Fibroblast grow... 3 4
Tyrosine-protein kinase ABL1 and Proto-oncogene tyrosine-prote... 1 0
Activated CDC42 kinase 1 inhibitor AGN-PC-078WDN family 7 2
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand SureC... 7 0
Metabotropic glutamate receptor 1 ligand AGN-PC-00FV3S family 2 0
Ribosomal protein S6 kinase beta-1 and Aurora kinase B inhibit... 1 5
Cannabinoid receptor 1 ligand AGN-PC-077JWI family 7 1
Nociceptin receptor and Mu-type opioid receptor ligand (1S,5S)... 1 0
LIM domain kinase 1 and LIM domain kinase 2 inhibitor (2S)-N'-... 9 0
RAC-alpha serine/threonine-protein kinase and RAC-beta serine/... 1 0
Dihydrofolate reductase inhibitor 5-[(7-chloro-10-methylsulfan... 1 0
D(4) dopamine receptor and D(2) dopamine receptor ligand SureC... 1 2
Adenosine receptor A1 and Adenosine receptor A2a ligand 2-(2-c... 2 0
Nitric oxide synthase, inducible inhibitor N-(3-chlorophenyl)-... 1 0
Epidermal growth factor receptor and Receptor tyrosine-protein... 1 0
Coagulation factor X and Prothrombin inhibitor SureCN6578740 f... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00362160 CHEMBL147257 Bioactive AC1LAKTA

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

45918 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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