CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM5210
Family Name Dihydrofolate reductase inhibitor AC1LAKQL family
No. of Seeds 3 No. of Other Members 1
Family Centroid CFAMM00362216 Functional Category Bioactive
Superfamily Epidermal growth factor receptor and Metabotropic glutamate receptor 5 Binder Superfamily
Class Class 202

Cousin Family NamesSeedsMembers
5-hydroxytryptamine receptor 2C ligand Tetracyclic antidepress... 14 498
Omega 1 Benzodiazepine receptor Ligand Zaleplon Family 6 589
Metabotropic glutamate receptor 5 Ligand ADX-48621 Family 15 444
C-X-C chemokine receptor type 4 Ligand AMD-070 Family 12 800
Transient receptor potential cation channel subfamily V member... 16 295
Transient receptor potential cation channel subfamily V member... 15 457
Transient receptor potential cation channel subfamily V member... 6 66
Fibroblast growth factor receptor 2 and Fibroblast growth fact... 11 86
Reverse transcriptase Inhibitor Dapivirine Family 5 72
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 14 234
Aurora kinase B and Aurora kinase C Inhibitor GSK1070916 Family 53 580
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 35 270
Histone deacetylase 6 Inhibitor ACY-1215 Family 10 230
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 8 55
Corticotropin-releasing factor receptor 1 Ligand CP-154526 Family 9 29
D(4) dopamine receptor Ligand L-745,870 Family 30 205
Corticotropin-releasing factor receptor 1 Ligand R121919 Family 26 84
Epidermal growth factor receptor and Receptor tyrosine-protein... 11 138
Beta-secretase 1 Inhibitor 6-[2-(1h-indol-6-yl)ethyl]pyridin-2... 10 43
Beta-secretase 1 Inhibitor N~3~-(3-pyridin-3-ylbenzyl)pyridine... 31 66
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 4 32
Steroid 17-alpha-hydroxylase/17,20 lyase and Aromatase Inhibit... 18 109
Vascular endothelial growth factor receptor 1 and Vascular end... 6 23
Epidermal growth factor receptor Ligand PD-158780 Family 98 89
Epidermal growth factor receptor Ligand N*4*-(3-bromo-phenyl)-... 7 11
Cyclin-dependent kinase 4 Inhibitor 1-pyridin-2-yl-3-quinolin-... 2 5
Scytalone dehydratase Inhibitor Isoquinolin-1-yl-(3-phenyl-pro... 4 9
Epidermal growth factor receptor Ligand Benzo[g]quinazolin-4-y... 5 3
Epidermal growth factor receptor Ligand (3-bromo-phenyl)-quina... 7 5
Cyclin-dependent kinase 1 Inhibitor CGP-60474 Family 14 103
Mitogen-activated protein kinase 3 and RAF proto-oncogene seri... 8 5
Epidermal growth factor receptor Ligand N4-(3-chlorophenyl)qui... 7 39
RAC-gamma serine/threonine-protein kinase and Rho-associated p... 16 46
Metabotropic glutamate receptor 5 Ligand 2-m-tolyl-1,8-naphthy... 7 11
DNA-dependent protein kinase catalytic subunit Inhibitor 2-mor... 2 6
Adenosine receptor A3 Ligand 1-(2-(diethylamino)quinazolin-4-y... 2 9
Mitogen-activated protein kinase 14 and Tyrosine-protein kinas... 3 9
Fatty-acid amide hydrolase 1 Inhibitor JNJ-1661010 Family 3 14
Macrophage migration inhibitory factor Inhibitor 4-iodo-6-phen... 5 4
Oestrogen receptor Ligand 4-benzyl-2,6-diisobutylamino-pyrimid... 5 37
Histamine H4 receptor Ligand A-943931 Family 14 11
RAF proto-oncogene serine/threonine-protein kinase Inhibitor L... 219 124
Glycogen synthase kinase-3 beta Inhibitor 4-(5-bromo-1h-indol-... 7 18
Proto-oncogene tyrosine-protein kinase Src Inhibitor CGP-62464... 3 10
Sodium channel protein type 1 subunit alpha and Sodium channel... 10 14
Metabotropic glutamate receptor 5 Ligand 2-(3-bromophenyl)-7-m... 3 1
Acetylcholinesterase Inhibitor N-benzyl-2-morpholinopyrimidin-... 6 16
Corticotropin-releasing factor receptor 1 ligand N-(2-bromo-4-... 5 0
Adenosine kinase inhibitor abt-702 family 14 1
Tyrosine-protein kinase JAK2 inhibitor AGN-PC-07ZB89 family 6 13
Aurora kinase A inhibitor AGN-PC-07ZZEH family 2 4
Adenosine kinase inhibitor 5-(4-chlorophenyl)-6-[2-(6-morpholi... 8 8
Adenosine kinase inhibitor 5-[3-(3-bromophenyl)propyl]-6-[2-(6... 3 0
Adenosine receptor A3 ligand 5-butyl-8-(4-methylsulfanylphenyl... 2 4
Epidermal growth factor receptor ligand AGN-PC-076GVG family 8 1
Epidermal growth factor receptor ligand pyrido[4,3-d]pyrimidin... 11 0
Epidermal growth factor receptor ligand AGN-PC-076GXM family 6 0
Serine/threonine-protein kinase pim-1 and Serine/threonine-pro... 7 9
Dihydrofolate reductase and Bifunctional dihydrofolate reducta... 5 0
Dihydrofolate reductase inhibitor 6-[[(4-chloronaphthalen-1-yl... 2 1
Corticotropin-releasing factor receptor 1 ligand 9-(2-bromo-4-... 15 3
Mu-type opioid receptor and Kappa-type opioid receptor ligand ... 3 0
Glycogen synthase kinase-3 beta and Cyclin-dependent kinase 4 ... 2 1
Cell division cycle 7-related protein kinase and Protein DBF4 ... 15 7
Serine/threonine-protein kinase TBK1 and Inhibitor of nuclear ... 1 0
Transient receptor potential cation channel subfamily V member... 4 0
Transient receptor potential cation channel subfamily V member... 4 0
Methionine--tRNA ligase inhibitor N-[(4R)-6,8-dibromo-1,2,3,4-... 1 1
Beta-secretase 1 and Potassium voltage-gated channel subfamily... 3 4
Adenosine kinase inhibitor 5-(4-bromophenyl)-6-[2-[4-(dimethyl... 1 0
Dihydrofolate reductase and Bifunctional dihydrofolate reducta... 3 5
Fatty-acid amide hydrolase 1 inhibitor 4-(3-phenyl-1,2,4-thiad... 2 1
Cathepsin K and Cathepsin S inhibitor SureCN4138353 family 3 0
LIM domain kinase 2 inhibitor (2S)-N-cyano-N'-(3-cyanophenyl)-... 4 0
Receptor-type tyrosine-protein kinase FLT3 and Mast/stem cell ... 7 2
Cathepsin K and Cathepsin L1 inhibitor 5-[3-(3,4-dihydro-1H-is... 2 0
Epidermal growth factor receptor ligand AGN-PC-076GWD family 2 0
Epidermal growth factor receptor ligand (E)-N-[4-(3-bromoanili... 2 1
Epidermal growth factor receptor ligand (E)-5-[4-(3-bromoanili... 11 0
Ribosomal protein S6 kinase beta-1 and Aurora kinase B inhibit... 1 5
LIM domain kinase 1 and LIM domain kinase 2 inhibitor (2S)-N'-... 9 0
Adenosine kinase inhibitor AGN-PC-074DKZ family 1 0
Cytochrome P450 1A2 inhibitor AGN-PC-0BTGP4 family 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00362218 CHEMBL151674 Bioactive AC1LAKV1
CFAMM00362217 CHEMBL147006 Bioactive AC1LAKY1
CFAMM00362216 CHEMBL150382 Bioactive AC1LAKQL

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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