CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM5231
Family Name Histamine H3 receptor ligand N-[(2R)-1-[4-[3-[4-(5-ethyl-1,2,4-oxadiazol-3-yl)-3-fluorophenoxy]propyl]-1,4-diazepan-1-yl]-1-oxopropan-2-yl]furan-2-carboxamide family
No. of Seeds 25 No. of Other Members 61
Family Centroid CFAMM00362430 Functional Category Bioactive with Natural Product
Superfamily Histamine H3 receptor and Inositol monophosphatase 1 Binder Superfamily
Class Class 2085

Cousin Family NamesSeedsMembers
Adenosine receptor A1 and Adenosine receptor A2a Ligand SB-298... 53 320
Adenosine receptor A1 and Adenosine receptor A2a ligand 2-[4-[... 12 15
Adenosine receptor A2b and Adenosine receptor A1 ligand SureCN... 52 12
Adenosine receptor A2b and Adenosine receptor A1 ligand MRS 17... 10 0
Prelamin-A/C and Nuclear receptor ROR-gamma ligand CHEMBL15310... 1 11
Histamine H3 receptor ligand N-[(2R)-1-[4-[3-[3-fluoro-4-(5-ph... 10 2
Histamine H3 receptor ligand SureCN7248940 family 20 0
Histamine H3 receptor ligand N-[(2R)-1-[4-[3-[4-[5-(cyclopenty... 27 2
Histamine H3 receptor ligand SureCN7252761 family 3 0
Histamine H3 receptor ligand SureCN7251693 family 3 1
Adenosine receptor A1 and Adenosine receptor A3 ligand SureCN5... 3 1
Sphingosine 1-phosphate receptor 1 and Sphingosine 1-phosphate... 3 0
Adenosine receptor A1 and Adenosine receptor A2b ligand (2,5-d... 2 0
Fatty-acid amide hydrolase 1 inhibitor AGN-PC-04UIF7 family 2 3
D(3) dopamine receptor ligand AGN-PC-00E8H5 family 1 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00362429 CHEMBL162355 Bioactive N-[(2R)-1-[4-[3-[4-[5-(2,2-dimethylpropyl)-1,2,4-oxadiazol-3-yl]-3-fluorophenoxy]propyl]-1,4-diazepan-1-yl]-1-oxopropan-2-yl]furan-2-carboxamide
CFAMM00362458 CHEMBL443817 Bioactive SureCN7243869
CFAMM00362485 CHEMBL157585 Bioactive N-[(2R)-1-[4-[3-[4-(5-cyclopropyl-1,2,4-oxadiazol-3-yl)-3-fluorophenoxy]propyl]piperazin-1-yl]-1-oxopropan-2-yl]furan-2-carboxamide
CFAMM00362491 CHEMBL349692 Bioactive SureCN7246578
CFAMM00362435 CHEMBL161283 Bioactive N-[(2R)-1-[4-[3-[3-fluoro-4-(5-pentan-3-yl-1,2,4-oxadiazol-3-yl)phenoxy]propyl]-1,4-diazepan-1-yl]-1-oxopropan-2-yl]furan-2-carboxamide
CFAMM00362484 CHEMBL158200 Bioactive tert-butyl N-[(1S)-1-[3-[2-fluoro-4-[3-[4-[(2R)-2-(furan-2-carbonylamino)propanoyl]-1,4-diazepan-1-yl]propoxy]phenyl]-1,2,4-oxadiazol-5-yl]ethyl]carbamate
CFAMM00362456 CHEMBL161346 Bioactive N-[(2R)-1-[4-[3-[4-(5-cyclohexyl-1,2,4-oxadiazol-3-yl)-3-fluorophenoxy]propyl]-1,4-diazepan-1-yl]-1-oxopropan-2-yl]furan-2-carboxamide
CFAMM00362470 CHEMBL158056 Bioactive N-[(2R)-1-[4-[3-[3-fluoro-4-(5-propan-2-yl-1,2,4-oxadiazol-3-yl)phenoxy]propyl]-1,4-diazepan-1-yl]-1-oxopropan-2-yl]furan-2-carboxamide
CFAMM00362434 CHEMBL158659 Bioactive SureCN7250303
CFAMM00362497 CHEMBL159240 Bioactive SureCN7245374
CFAMM00362449 CHEMBL158632 Bioactive tert-butyl N-[1-[3-[2-fluoro-4-[3-[4-[(2R)-2-(furan-2-carbonylamino)propanoyl]-1,4-diazepan-1-yl]propoxy]phenyl]-1,2,4-oxadiazol-5-yl]-2-methylpropyl]carbamate
CFAMM00362462 CHEMBL161056 Bioactive N-[(2R)-1-[4-[3-[4-(5-cyclopropyl-1,2,4-oxadiazol-3-yl)-3-fluorophenoxy]propyl]-1,4-diazepan-1-yl]-1-oxopropan-2-yl]furan-2-carboxamide
CFAMM00362426 CHEMBL158714 Bioactive SureCN7242895
CFAMM00362419 CHEMBL352895 Bioactive N-[(2R)-1-[4-[3-[3-fluoro-4-[5-(furan-2-yl)-1,2,4-oxadiazol-3-yl]phenoxy]propyl]-1,4-diazepan-1-yl]-1-oxopropan-2-yl]furan-2-carboxamide
CFAMM00362488 CHEMBL160680 Bioactive N-[(2R)-1-[4-[3-[3-fluoro-4-[5-(oxolan-2-yl)-1,2,4-oxadiazol-3-yl]phenoxy]propyl]-1,4-diazepan-1-yl]-1-oxopropan-2-yl]furan-2-carboxamide
CFAMM00362454 CHEMBL157534 Bioactive N-[(2R)-1-[4-[3-[4-[5-(cyclohexylmethyl)-1,2,4-oxadiazol-3-yl]-3-fluorophenoxy]propyl]-1,4-diazepan-1-yl]-1-oxopropan-2-yl]furan-2-carboxamide
CFAMM00362481 CHEMBL158765 Bioactive N-[(2R)-1-[4-[3-[4-(5-benzyl-1,2,4-oxadiazol-3-yl)-3-fluorophenoxy]propyl]-1,4-diazepan-1-yl]-1-oxopropan-2-yl]furan-2-carboxamide
CFAMM00362467 CHEMBL158228 Bioactive N-[(2R)-1-[4-[3-[4-(5-cycloheptyl-1,2,4-oxadiazol-3-yl)-3-fluorophenoxy]propyl]-1,4-diazepan-1-yl]-1-oxopropan-2-yl]furan-2-carboxamide
CFAMM00362418 CHEMBL348279 Bioactive SureCN7248389
CFAMM00362446 CHEMBL161202 Bioactive SureCN7248946
CFAMM00362411 CHEMBL435848 Bioactive N-[(2R)-1-[4-[3-[4-(5-tert-butyl-1,2,4-oxadiazol-3-yl)-3-fluorophenoxy]propyl]-1,4-diazepan-1-yl]-1-oxopropan-2-yl]furan-2-carboxamide
CFAMM00362487 CHEMBL160729 Bioactive SureCN7247947
CFAMM00362430 CHEMBL161456 Bioactive N-[(2R)-1-[4-[3-[4-(5-ethyl-1,2,4-oxadiazol-3-yl)-3-fluorophenoxy]propyl]-1,4-diazepan-1-yl]-1-oxopropan-2-yl]furan-2-carboxamide
CFAMM00362473 CHEMBL351497 Bioactive N-[(2R)-1-[4-[3-[3-fluoro-4-(5-pyridin-3-yl-1,2,4-oxadiazol-3-yl)phenoxy]propyl]-1,4-diazepan-1-yl]-1-oxopropan-2-yl]furan-2-carboxamide
CFAMM00362409 CHEMBL14720 Bioactive N-[(2R)-1-[4-[3-[3-fluoro-4-[5-(2-methylpropyl)-1,2,4-oxadiazol-3-yl]phenoxy]propyl]-1,4-diazepan-1-yl]-1-oxopropan-2-yl]furan-2-carboxamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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