CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM5247
Family Name Substance-P receptor ligand 4-[1-[2-[1-(cyclopropylmethyl)-3-(3,4-dichlorophenyl)-6-oxopiperidin-3-yl]ethyl]azetidin-3-yl]-N,N-dimethylpiperazine-1-sulfonamide family
No. of Seeds 10 No. of Other Members 6
Family Centroid CFAMM00362621 Functional Category Bioactive
Superfamily Neuromedin-K receptor Ligand Osanetant Superfamily
Class Class 908

Cousin Family NamesSeedsMembers
Neuromedin-K receptor Ligand Osanetant Family 38 192
Substance-K receptor and Substance-P receptor Ligand DNK-333 F... 15 95
Tumor necrosis factor Inhibitor Talactoferrin Alfa Family 26 131
3-oxo-5-alpha-steroid 4-dehydrogenase 1 Inhibitor 5-(4-chloro-... 10 52
Sodium-dependent dopamine transporter and Sodium-dependent nor... 19 28
Sodium-dependent dopamine transporter Inhibitor (+/-)-threo-3'... 14 11
Substance-P receptor ligand 1-benzyl-5-(3,4-dichlorophenyl)-5-... 9 0
Substance-K receptor ligand (5S)-1-(2-cyclopropylethyl)-5-(3,4... 10 0
Substance-P receptor ligand 1-benzyl-5-(3,4-dichlorophenyl)-5-... 5 0
Substance-P receptor ligand 1-benzyl-5-(3,4-dichlorophenyl)-5-... 3 0
Substance-P receptor ligand 1-benzyl-5-(3,4-dichlorophenyl)-5-... 2 0
Substance-P receptor ligand 1-(cyclohexylmethyl)-5-(3,4-dichlo... 8 1
Sigma non-opioid intracellular receptor 1 ligand 1-[2-(3,4-dic... 8 4
Neuromedin-K receptor ligand (1S,2R)-1-(3,4-dichlorophenyl)-N-... 8 0
Substance-K receptor ligand SureCN3083325 family 4 0
Substance-P receptor ligand 1-benzyl-5-(3,4-dichlorophenyl)-5-... 1 1
Neuromedin-K receptor and Substance-K receptor ligand AGN-PC-0... 2 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00362606 CHEMBL357357 Bioactive 1-(cyclopropylmethyl)-5-(3,4-dichlorophenyl)-5-[2-[3-(4-methylsulfonylpiperazin-1-yl)azetidin-1-yl]ethyl]piperidin-2-one
CFAMM00362620 CHEMBL345733 Bioactive 4-[1-[2-[1-(cyclopropylmethyl)-3-(3,4-dichlorophenyl)-6-oxopiperidin-3-yl]ethyl]azetidin-3-yl]-N-methylpiperazine-1-sulfonamide
CFAMM00362613 CHEMBL148998 Bioactive 4-[1-[2-[1-(cyclopropylmethyl)-3-(3,4-dichlorophenyl)-6-oxopiperidin-3-yl]ethyl]azetidin-3-yl]piperazine-1-sulfonamide
CFAMM00362605 CHEMBL185452 Bioactive (5S)-1-(cyclopropylmethyl)-5-(3,4-dichlorophenyl)-5-[2-[3-(4-methylsulfonylpiperazin-1-yl)azetidin-1-yl]ethyl]piperidin-2-one
CFAMM00362612 CHEMBL365613 Bioactive 4-[1-[2-[(3S)-1-(cyclopropylmethyl)-3-(3,4-dichlorophenyl)-6-oxopiperidin-3-yl]ethyl]azetidin-3-yl]piperazine-1-sulfonamide
CFAMM00362617 CHEMBL357946 Bioactive N-[1-[1-[2-[1-(cyclopropylmethyl)-3-(3,4-dichlorophenyl)-6-oxopiperidin-3-yl]ethyl]azetidin-3-yl]piperidin-4-yl]methanesulfonamide
CFAMM00362615 CHEMBL423584 Bioactive 1-benzyl-5-(3,4-dichlorophenyl)-5-[2-[3-(4-methylsulfonylpiperazin-1-yl)azetidin-1-yl]ethyl]piperidin-2-one
CFAMM00362607 CHEMBL185007 Bioactive 4-[1-[2-[(3S)-1-(cyclopropylmethyl)-3-(3,4-dichlorophenyl)-6-oxopiperidin-3-yl]ethyl]azetidin-3-yl]-N,N-dimethylpiperazine-1-sulfonamide
CFAMM00362621 CHEMBL147301 Bioactive 4-[1-[2-[1-(cyclopropylmethyl)-3-(3,4-dichlorophenyl)-6-oxopiperidin-3-yl]ethyl]azetidin-3-yl]-N,N-dimethylpiperazine-1-sulfonamide
CFAMM00362614 CHEMBL185182 Bioactive (5S)-5-(3,4-dichlorophenyl)-1-[(4,4-difluorocyclohexyl)methyl]-5-[2-[3-(4-methylsulfonylpiperazin-1-yl)azetidin-1-yl]ethyl]piperidin-2-one

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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