CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM5318
Family Name Endothelin-converting enzyme 1 and Neprilysin inhibitor (2S)-2-[[(2S)-2-[[(2S)-5-(2,4-difluorophenyl)-2-(phosphonomethylamino)pent-4-ynoyl]amino]-4-methylpentanoyl]amino]propanoic acid family
No. of Seeds 1 No. of Other Members 8
Family Centroid CFAMM00363048 Functional Category Bioactive
Superfamily Neprilysin and Endothelin-converting enzyme 1 Binder Superfamily
Class Class 1787

Cousin Family NamesSeedsMembers
Angiotensin-converting enzyme inhibitor Dicarboxylate-containi... 16 374
Angiotensin-converting enzyme Inhibitor Spirapril Family 17 86
Angiotensin-converting enzyme inhibitor Dicarboxylate-containi... 7 54
ATP-sensitive inward rectifier potassium channel 10 Ligand Nat... 3 233
Dipeptidyl peptidase 4 Inhibitor Denagliptin Family 24 151
Proto-oncogene tyrosine-protein kinase Src Inhibitor RU83876 F... 3 51
Plasmepsin-1 Inhibitor SC-5003 Family 93 173
Histone deacetylase 1 and Histone deacetylase 4 Inhibitor Azum... 3 10
Endothelin-converting enzyme 1 Inhibitor PO3 2-leu-nal-o-3k Fa... 3 26
Genome polyprotein Inhibitor Acdif-ile-cha-cys Family 37 96
Neprilysin and Aminopeptidase N inhibitor (2S)-2-[[(2S)-2-[[[a... 13 1
Aminopeptidase N and Neprilysin inhibitor (2S)-2-[[(2S)-2-[[[(... 1 0
Carboxypeptidase B and Carboxypeptidase B2 inhibitor (2S)-7-am... 3 9
Neprilysin inhibitor SureCN489232 family 3 9
Endothelin-converting enzyme 1 and Neprilysin inhibitor [[(2S)... 2 2
Endothelin-converting enzyme 1 and Neprilysin inhibitor [[(2S)... 1 1


External ID

Functional Category

Molecule Name

CFAMM00363048 CHEMBL147847 Bioactive (2S)-2-[[(2S)-2-[[(2S)-5-(2,4-difluorophenyl)-2-(phosphonomethylamino)pent-4-ynoyl]amino]-4-methylpentanoyl]amino]propanoic acid

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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