CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM5407
Family Name Neprilysin inhibitor SureCN489232 family
No. of Seeds 3 No. of Other Members 9
Family Centroid CFAMM00363607 Functional Category Bioactive with Natural Product
Superfamily Neprilysin and Dipeptidyl peptidase 4 Binder Superfamily
Class Class 260

Cousin Family NamesSeedsMembers
Vasopressin V1a receptor Ligand Felypressin Family 12 820
Penicillin binding protein inhibitor β-lactam aminopenicillin ... 12 359
Alpha-1B adrenergic receptor Ligand Lisdexamfetamine Family 14 443
Angiotensin-converting enzyme inhibitor Dicarboxylate-containi... 16 374
Angiotensin-converting enzyme inhibitor Phosphonate-containing... 7 41
Angiotensin-converting enzyme Inhibitor Quinapril Family 3 105
Angiotensin-converting enzyme Inhibitor Spirapril Family 17 86
Angiotensin-converting enzyme inhibitor Dicarboxylate-containi... 7 54
ATP-sensitive inward rectifier potassium channel 10 Ligand Nat... 3 233
Bacterial outer membrane Inhibitor Polymyxin B Family 17 181
Angiotensin-converting enzyme and Neprilysin Inhibitor M100,24... 18 60
Dopamine reuptake Inhibitor Amineptine Family 2 5
Melanocortin receptor 4 Ligand Ro-27-3225 Family 6 52
Dipeptidyl peptidase 4 Inhibitor Denagliptin Family 24 151
Integrin alpha-V and Integrin beta-3 Inhibitor C[rgd-(s)-alpha... 19 95
Neprilysin Inhibitor Thiorphan Family 41 68
Neuromedin-K receptor Ligand Senktide Family 15 22
Proto-oncogene tyrosine-protein kinase Src Inhibitor RU83876 F... 3 51
Cathepsin F and Cruzipain Inhibitor WRR-99 Family 13 131
Penicillin-binding protein 1B Inhibitor N-benzoyl-d-alanine Fa... 1 40
Beta-secretase 1 Inhibitor MMI-175 Family 30 137
72 kDa type IV collagenase and Matrix metalloproteinase-9 Inhi... 40 87
Farnesyltransferase beta subunit, putative and Protein farnesy... 24 82
Disintegrin and metalloproteinase domain-containing protein 17... 8 7
Plasmepsin-1 Inhibitor SC-5003 Family 93 173
Cathepsin B and Cathepsin L1 Inhibitor MDL-2170 Family 17 24
Neuromedin-K receptor Ligand PD-157672 Family 9 37
Beta-secretase 1 Inhibitor Glu-leu-asp-leu-(choh-ch2)-ala-ala-... 15 11
Cathepsin K and Cathepsin L1 Inhibitor N-benzoyl-phenylalanyl-... 13 77
Melanocortin receptor 3 and Melanocortin receptor 4 Ligand Tic... 11 31
Cathepsin B and Cathepsin S Inhibitor Ac-hphe-leu-ala-leuvsme ... 17 51
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 6 24
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 14 110
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 3 21
Delta-type opioid receptor Ligand H-cxp-ala-gly-phe-leu-oh Family 1 8
Histone deacetylase 1 and Histone deacetylase 4 Inhibitor Azum... 3 10
Disks large homolog 4 Inhibitor N-(3,4-difluorophenyl)propyl-e... 3 0
DNA (cytosine-5)-methyltransferase 3B Inhibitor NSC-154957 Family 2 3
Baculoviral IAP repeat-containing protein 3 and E3 ubiquitin-p... 44 28
Receptor-type tyrosine-protein phosphatase C Ligand Asp-brpmp-... 2 0
Endothelin-converting enzyme 1 Inhibitor PO3 2-leu-nal-o-3k Fa... 3 26
Sodium channel protein type 1 subunit alpha and Sodium channel... 4 31
Genome polyprotein Inhibitor Acasp-glu-dif-glu-cha-cys Family 13 17
Genome polyprotein Inhibitor Acasp-glu-met-glu-cha-cys Family 3 6
Genome polyprotein Inhibitor Acdif-ile-cha-cys Family 37 96
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 152 36
Prolyl endopeptidase Inhibitor SUAM-1221 Family 42 47
Mu-type opioid receptor and Nociceptin receptor Ligand Nocicep... 35 5
Aminopeptidase N Inhibitor 2-cinnamamido-n4-hexyl-n1-hydroxysu... 24 8
Cholecystokinin receptor type A Ligand CR-1795 Family 19 41
Melanocortin receptor 4 and Melanocyte-stimulating hormone rec... 3 10
Angiotensin-converting enzyme inhibitor (S)-1-((S)-5-benzamido... 5 2
Neprilysin and Aminopeptidase N inhibitor (2S)-2-[[(2S)-2-[[[a... 13 1
Aminopeptidase N and Neprilysin inhibitor (2S)-2-[[(2S)-2-[[[(... 1 0
Carboxypeptidase B and Carboxypeptidase B2 inhibitor (2S)-7-am... 3 9
Glutamate receptor ionotropic, kainate 2 ligand (2S,3S,4S)-4-[... 14 2
Cathepsin K and Cathepsin S inhibitor (2S)-N-(cyanomethyl)-2-[... 14 4
Renin and Cathepsin D inhibitor (3S)-4-[[6-acetamido-2-[[3-nap... 6 26
Pol polyprotein inhibitor Lysine Sulfonamide 11c family 3 73
Endothelin-converting enzyme 1 and Neprilysin inhibitor (2S)-2... 1 8
Integrin beta-3 and Integrin alpha-IIb inhibitor (3R)-5-phenyl... 4 1
Growth factor receptor-bound protein 2 ligand 2-[(9S,10S,11E,1... 5 14
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-2-[(1-cycl... 1 6
Matrix metalloproteinase-9 inhibitor (3R)-2-[ethoxy-(4-phenylp... 4 15
Growth factor receptor-bound protein 2 ligand [4-[[(2S,5S,9S,1... 2 1
Endothelin-converting enzyme 1 and Cathepsin D inhibitor N-[(2... 6 2
Neprilysin and Angiotensin-converting enzyme inhibitor (2S)-2-... 5 3
72 kDa type IV collagenase and Stromelysin-1 inhibitor (2S,4R)... 5 8
Angiotensin-converting enzyme inhibitor (2S,4R)-1-[(2S)-6-amin... 3 1
Type-2 angiotensin II receptor ligand SureCN3515167 family 2 0
Neprilysin inhibitor SureCN7437961 family 2 6
Follicle-stimulating hormone receptor ligand N-[[3-[4-[[(2S,5S... 7 0
Collagenase 3 and Interstitial collagenase inhibitor (4-benzyl... 2 0
Tyrosine-protein phosphatase non-receptor type 1 and Tyrosine-... 1 1
Chymase and Chymotrypsinogen B inhibitor AGN-PC-075LTI family 2 3
Histone deacetylase 1 and Histone deacetylase 8 inhibitor meth... 1 3
Neprilysin inhibitor AGN-PC-075S5F family 1 1
Calpain-1 catalytic subunit inhibitor Peptidyl alpha-Ketoacid,... 1 0
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 1 6
Neutrophil collagenase and Macrophage metalloelastase inhibito... 1 0
Gamma-secretase subunit PEN-2 inhibitor SureCN5966881 family 1 9
Endothelin-converting enzyme 1 and Neprilysin inhibitor [[(2S)... 2 2
Tubulin beta-1 chain inhibitor SureCN6672529 family 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00363607 CHEMBL148521 Bioactive SureCN489232
CFAMM00363600 CHEMBL285038 Bioactive 3-({(2s)-3-(biphenyl-4-yl)-2-[(phosphonomethyl)amino]propanoyl}amino)propanoic acid(non-preferred name)
CFAMM00363602 CHEMBL357903 Bioactive SureCN7319125

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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