CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM5414
Family Name Cyclin-dependent kinase 4 and G1/S-specific cyclin-D1 inhibitor acylsemicarbazide deriv. 3ac family
No. of Seeds 19 No. of Other Members 40
Family Centroid CFAMM00363673 Functional Category Bioactive
Superfamily G1/S-specific cyclin-D1 and Cyclin-dependent kinase 4 Binder Superfamily
Class Class 999

Cousin Family NamesSeedsMembers
Serine/threonine-protein kinase Chk1 Inhibitor A-432411 Family 4 70
5-hydroxytryptamine receptor 2C Ligand N-(6-phenoxypyridin-3-y... 9 69
Vasopressin V1a receptor and Vasopressin V2 receptor ligand (3... 4 41
MAP kinase-activated protein kinase 2 and Mitogen-activated pr... 4 0
MAP kinase-activated protein kinase 2 inhibitor CHEMBL1801290 ... 3 0
Cyclin-dependent kinase 4 and G1/S-specific cyclin-D1 inhibito... 8 0
Serine/threonine-protein kinase RIO2 and Serine/threonine-prot... 19 10
Serine/threonine-protein kinase RIO2 and Serine/threonine-prot... 12 13
Smoothened homolog and Mitogen-activated protein kinase 14 inh... 3 0
Serine/threonine-protein kinase Chk1 inhibitor SureCN6786833 f... 4 6
Serine/threonine-protein kinase PLK4 inhibitor 4-[(E)-2-[6-[(E... 2 3
Serine/threonine-protein kinase PLK4 inhibitor (3E)-5-methoxy-... 4 0
Serine/threonine-protein kinase PLK4 inhibitor (3E)-3-[[3-[(E)... 1 1


External ID

Functional Category

Molecule Name

CFAMM00363675 CHEMBL346164 Bioactive Indenopyrazole 11a
CFAMM00363668 CHEMBL362756 Bioactive acylsemicarbazide deriv. 3v
CFAMM00363681 CHEMBL148580 Bioactive Indenopyrazole 6p
CFAMM00363687 CHEMBL148889 Bioactive Indenopyrazole 6n
CFAMM00363667 CHEMBL183204 Bioactive acylsemicarbazide deriv. 3d
CFAMM00363633 CHEMBL358102 Bioactive Indenopyrazole 11i
CFAMM00363673 CHEMBL360644 Bioactive acylsemicarbazide deriv. 3ac
CFAMM00363686 CHEMBL186661 Bioactive acylsemicarbazide deriv. 3c
CFAMM00363640 CHEMBL183950 Bioactive acylsemicarbazide deriv. 3m
CFAMM00363666 CHEMBL185525 Bioactive acylsemicarbazide deriv. 3a
CFAMM00363639 CHEMBL184131 Bioactive acylsemicarbazide deriv. 3k
CFAMM00363631 CHEMBL346184 Bioactive Indenopyrazole 6k
CFAMM00363658 CHEMBL363077 Bioactive acylsemicarbazide deriv. 3x
CFAMM00363651 CHEMBL186656 Bioactive acylsemicarbazide deriv. 3g
CFAMM00363677 CHEMBL362109 Bioactive acylsemicarbazide deriv. 3o
CFAMM00363630 CHEMBL188010 Bioactive acylsemicarbazide deriv. 3w
CFAMM00363670 CHEMBL185781 Bioactive acylsemicarbazide deriv. 3s
CFAMM00363650 CHEMBL345525 Bioactive Indenopyrazole 11j
CFAMM00363663 CHEMBL188005 Bioactive acylsemicarbazide deriv. 3ad

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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