CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM544
Family Name Histamine H3 receptor and Potassium voltage-gated channel subfamily H member 2 ligand SureCN1640231 family
No. of Seeds 2 No. of Other Members 21
Family Centroid CFAMM00313088 Functional Category Bioactive
Superfamily Substance-P receptor Ligand R 673 Superfamily
Class Class 994

Cousin Family NamesSeedsMembers
Cyclooxygenase Inhibitor Oxaprozin Family 33 450
Substance-P receptor Ligand R 673 Family 2 127
72 kDa type IV collagenase and Matrix metalloproteinase-9 Inhi... 37 265
C-C chemokine receptor type 2 and C-C motif chemokine 2 Ligand... 3 52
Peroxisome proliferator-activated receptor gamma and Peroxisom... 15 94
Melatonin receptor type 1B Ligand N-(3-benzooxazol-7-yl-propyl... 26 101
Fatty-acid amide hydrolase 1 Inhibitor (z)-1-(benzo[d]oxazol-2... 2 27
Fatty-acid amide hydrolase 1 Inhibitor 1-(oxazolo[4,5-b]pyridi... 19 34
Fatty-acid amide hydrolase 1 Inhibitor 1-(5-(pyridin-2-yl)oxaz... 10 142
Prostacyclin receptor and Prostaglandin E2 receptor EP3 subtyp... 4 17
Neuromedin-K receptor Ligand 3-methoxy-n',2-diphenylquinoline-... 14 33
Neutrophil elastase Inhibitor Cbz-val-pro-val-(2-benzoxazole) ... 32 64
Estradiol 17-beta-dehydrogenase 1 Inhibitor 3-[5-(4-hydroxyphe... 4 36
Leukotriene A-4 hydrolase Inhibitor 2-[4-(2-azepan-1-ylethoxy)... 5 15
Peroxisome proliferator-activated receptor alpha Ligand BMS-68... 10 16
Fatty-acid amide hydrolase 1 Inhibitor 7-phenyl-1-(5-phenyloxa... 3 3
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 1 4
Fatty-acid amide hydrolase 1 Inhibitor 3-(benzo[d]oxazol-2-yl)... 1 6
Alpha-2B adrenergic receptor and Alpha-2C adrenergic receptor ... 4 4
Peroxisome proliferator-activated receptor delta and Peroxisom... 2 7
Peroxisome proliferator-activated receptor delta ligand SureCN... 8 19
Muscarinic acetylcholine receptor M3 ligand [(3R)-1-[3-(1,3-be... 3 2
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK1 ... 5 25
Collagenase 3 inhibitor N-[[3-[5-[[(1R)-1-cyclohexyl-2-(methyl... 4 2
Histone deacetylase 1 and Histone deacetylase 2 inhibitor AGN-... 4 15
D(3) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 10 50
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 4 6
5-hydroxytryptamine receptor 3A ligand 2-[(3S)-3-ethylmorpholi... 10 18
Prelamin-A/C inhibitor CHEMBL1374443 family 1 6
Thyroid hormone receptor beta ligand CHEMBL1397256 family 1 12
Fatty-acid amide hydrolase 1 inhibitor SureCN1471727 family 2 19
B2 bradykinin receptor ligand SureCN6640854 family 7 4
Thromboxane-A synthase and Thromboxane A2 receptor ligand Sure... 5 37
Inosine-5'-monophosphate dehydrogenase inhibitor SureCN1318237... 2 12
Fatty-acid amide hydrolase 1 inhibitor methyl 6-[2-[3-(4-pheny... 8 5
Fatty-acid amide hydrolase 1 inhibitor [(2S)-6-phenoxy-1,2,3,4... 3 6
Neprilysin and Natriuretic peptides A inhibitor (2S)-2-[[1-[[(... 3 3
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic ... 5 12
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic ... 4 1
Peroxisome proliferator-activated receptor gamma and Peroxisom... 4 1
Sphingosine 1-phosphate receptor 1 ligand 6-[2-[4-phenyl-3-(tr... 2 3
Sphingosine 1-phosphate receptor 1 and Sphingosine 1-phosphate... 14 24
Prostaglandin E2 receptor EP4 subtype and Prostaglandin E2 rec... 7 1
Peroxisome proliferator-activated receptor gamma and Peroxisom... 1 3
Oxysterols receptor LXR-alpha and Oxysterols receptor LXR-beta... 4 3
Peroxisome proliferator-activated receptor alpha and Peroxisom... 5 2
Peroxisome proliferator-activated receptor gamma and Peroxisom... 10 5
Peroxisome proliferator-activated receptor gamma and Peroxisom... 3 0
Fatty-acid amide hydrolase 1 inhibitor alpha-ketooxazole, 4jj ... 1 1
Fatty-acid amide hydrolase 1 inhibitor alpha-ketooxazole, 5a f... 2 1
Peroxisome proliferator-activated receptor alpha and Peroxisom... 2 1
Cathepsin K inhibitor N-[(2S)-4-methyl-1-[2-[4-(2-methylpropox... 4 0
D(3) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 2 0
Peroxisome proliferator-activated receptor gamma and Peroxisom... 7 2
Fatty-acid amide hydrolase 1 inhibitor AGN-PC-04UH7Y family 4 1
Peroxisome proliferator-activated receptor gamma and Peroxisom... 4 3
D(4) dopamine receptor ligand SureCN8704964 family 1 2
Metabotropic glutamate receptor 5 ligand SureCN504754 family 5 4
Diacylglycerol O-acyltransferase 1 inhibitor N-(3-oxo-1-propyl... 1 0
Potassium voltage-gated channel subfamily H member 2 and ATP-s... 1 0
Metabotropic glutamate receptor 5 ligand 3-fluoro-5-(5-pyridin... 1 0
Fatty-acid amide hydrolase 1 inhibitor 7-phenyl-1-[5-[6-(2H-te... 2 0
2-enenitrile NP ZINC05025155 Family 2 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00313082 CHEMBL402187 Bioactive 5-methyl-4-[2-[(2R)-2-methylpyrrolidin-1-yl]ethyl]-2-phenyl-1,3-oxazole
CFAMM00313088 CHEMBL1083274 Bioactive SureCN1640231

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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