CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM5442
Family Name Cathepsin S and Cathepsin K inhibitor N-[(2S)-3-(1-methylcyclohexyl)-1-[[(4S,7R)-7-methyl-3-oxo-1-(pyridine-2-carbonyl)azepan-4-yl]amino]-1-oxopropan-2-yl]furan-2-carboxamide family
No. of Seeds 2 No. of Other Members 0
Family Centroid CFAMM00137690 Functional Category Bioactive
Superfamily Survival motor neuron protein and Cathepsin K Binder Superfamily
Class Class 1163

Cousin Family NamesSeedsMembers
Cathepsin K Inhibitor Relacatib Family 26 32
Calcium-activated potassium channel subunit alpha-1 Ligand AVE... 3 284
Neuronal acetylcholine receptor subunit alpha-4 Ligand TC-5619... 3 61
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 12 197
5-hydroxytryptamine receptor 1B Ligand GR55562 Family 3 45
Inosine-5'-monophosphate dehydrogenase 2 Inhibitor 2-benzyl-6-... 9 80
Fatty-acid amide hydrolase 1 Inhibitor 1-(5-(pyridin-2-yl)oxaz... 10 142
Vascular endothelial growth factor receptor 1 Ligand Lycogarub... 6 292
DNA-dependent protein kinase catalytic subunit Inhibitor 8-(1h... 3 85
Inosine-5'-monophosphate dehydrogenase 2 Inhibitor 3-(furan-3-... 3 44
RAC-gamma serine/threonine-protein kinase Inhibitor A-443654 F... 67 59
Mu-type opioid receptor Ligand 6-(4-(2-(benzylamino)ethyl)phen... 3 27
Neutrophil elastase Inhibitor Cbz-val-pro-val-(2-benzoxazole) ... 32 64
5-hydroxytryptamine receptor 3A and Neuronal acetylcholine rec... 1 3
5-hydroxytryptamine receptor 2C Ligand N-(6-phenoxypyridin-3-y... 9 69
Bifunctional epoxide hydrolase 2 Inhibitor N-benzyl-6-(3,3,3-t... 21 62
Adenosine receptor A1 and Adenosine receptor A2a Ligand N-(2-(... 21 108
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 14 48
Collagenase 3 inhibitor N-[[3-[5-[[(1R)-1-cyclohexyl-2-(methyl... 6 9
Collagenase 3 inhibitor N-[[3-[5-[[(1R)-1-cyclohexyl-2-(methyl... 4 2
Disintegrin and metalloproteinase domain-containing protein 17... 2 1
Growth hormone secretagogue receptor type 1 ligand 2-amino-N-[... 3 3
Cytochrome P450 2C19 and Inositol monophosphatase 1 inhibitor ... 1 0
Fatty-acid amide hydrolase 1 inhibitor methyl 6-[2-[3-(4-pheny... 8 5
Fatty-acid amide hydrolase 1 inhibitor [(2S)-6-phenoxy-1,2,3,4... 3 6
Serine/threonine-protein kinase B-raf inhibitor furan-based co... 6 3
Mu-type opioid receptor ligand AGN-PC-075GBK family 4 4
RAC-alpha serine/threonine-protein kinase inhibitor 5-[5-[(2S)... 14 2
Serine/threonine-protein kinase pim-2 and cGMP-dependent prote... 8 1
Sphingosine 1-phosphate receptor 1 ligand 6-[2-[4-phenyl-3-(tr... 2 3
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand N-(1-... 3 2
Mu-type opioid receptor and Mu-type opioid receptor ligand (3S... 6 2
Peroxisome proliferator-activated receptor gamma and Peroxisom... 10 5
Collagenase 3 inhibitor AGN-PC-03HW1J family 4 0
Beta-2 adrenergic receptor and Beta-3 adrenergic receptor liga... 1 5
Macrophage colony-stimulating factor 1 receptor ligand 5-cyano... 1 0
Cathepsin K and Cathepsin L1 inhibitor AC1NR9VX family 2 2
Integrin beta-3 and Integrin alpha-V inhibitor AGN-PC-073HN6 f... 1 1
Substance-P receptor ligand SureCN2139814 family 7 7
Interstitial collagenase and Matrilysin inhibitor (3S,6R,7S)-N... 2 4
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 3 3
RAC-alpha serine/threonine-protein kinase inhibitor Isoquinoli... 1 0
Substance-P receptor ligand AGN-PC-0D60L0 family 2 7
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 6 0
Protein kinase C theta type and Protein kinase C delta type in... 5 4
Bombesin receptor subtype-3 ligand 2-[[(E)-furan-2-ylmethylide... 2 4
Collagenase 3 inhibitor SureCN1316041 family 4 3
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 1 3
Metabotropic glutamate receptor 5 ligand 3-fluoro-5-(5-pyridin... 1 0
2-amino-6-(furan-2-ylmethyl)-7-methyl-5-oxo-4-pyridin-3-yl-4H-... 2 0


CFAM Mol ID

External ID

Functional Category

Molecule Name


Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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