CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM5458
Family Name Dihydrofolate reductase and Bifunctional dihydrofolate reductase-thymidylate synthase inhibitor SRI 8455 family
No. of Seeds 3 No. of Other Members 3
Family Centroid CFAMM00363959 Functional Category Bioactive
Superfamily Adenosine kinase and Survival motor neuron protein Binder Superfamily
Class Class 3591

Cousin Family NamesSeedsMembers
Peptide deformylase, mitochondrial Inhibitor Trimethoprim Family 67 482
Histamine H1 receptor Ligand Mepyramine Family 5 65
Corticotropin-releasing factor receptor 1 Ligand CRF-1 Antagon... 29 421
Hypoxia-inducible factor 1-alpha Inhibitor Hif-1alpha Family 7 107
Receptor tyrosine-protein kinase erbB-2 Inhibitor CP-724714 Fa... 4 180
Insulin-like growth factor 1 receptor Ligand AEW-541 Family 12 140
AP26113 family 16 90
Peptide deformylase, mitochondrial Inhibitor Epiroprim Family 5 68
Angiopoietin-1 receptor and Tyrosine-protein kinase Lck Inhibi... 3 64
Cyclin-dependent kinase 2 and Cyclin-dependent kinase 9 Inhibi... 10 35
Cyclin-dependent kinase 2 and Cyclin-dependent kinase 4 Inhibi... 19 48
Platelet-derived growth factor receptor alpha and Fibroblast g... 3 47
Enoyl-[acyl-carrier-protein] reductase [NADH] Inhibitor 5-hexy... 2 3
Reverse transcriptase Inhibitor UK-129485 Family 23 221
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 6 35
Adenosine receptor A3 ligand CHEMBL1834696 family 5 18
Adenosine kinase inhibitor 5-[3-(4-methoxyphenyl)propyl]-6-[2-... 2 11
Cellular tumor antigen p53 inhibitor CHEMBL1401545 family 1 25
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 3 14
Dual specificity tyrosine-phosphorylation-regulated kinase 1A ... 3 20
Dihydrofolate reductase inhibitor AC1LA5HU family 8 4
Dihydrofolate reductase inhibitor AC1L9XPA family 6 5
Adenosine kinase inhibitor SureCN8134468 family 3 7
Bifunctional dihydrofolate reductase-thymidylate synthase and ... 6 13
Lethal factor and Dual specificity protein kinase CLK4 inhibit... 1 3
cAMP-specific 3',5'-cyclic phosphodiesterase 4A inhibitor Sure... 14 8
Insulin-like growth factor 1 receptor ligand 3qqu family 2 12
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 6 0
Corticotropin-releasing factor receptor 1 and Corticotropin-re... 2 1
Rho-associated protein kinase 1 and cAMP-dependent protein kin... 1 11
Bifunctional dihydrofolate reductase-thymidylate synthase and ... 7 16
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 18 1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 4 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 4 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 3 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 1 1
Transient receptor potential cation channel subfamily V member... 2 4
Histone-arginine methyltransferase CARM1 inhibitor AGN-PC-00HE... 4 4
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 2 2
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 2 1
Cathepsin K and Cathepsin S inhibitor SureCN4135077 family 2 0
Dihydrofolate reductase inhibitor AC1LAPW3 family 3 0
Dihydrofolate reductase inhibitor AGN-PC-001U7R family 3 0
Bifunctional dihydrofolate reductase-thymidylate synthase and ... 1 3
Tyrosine-protein kinase SYK and Tyrosine-protein kinase ZAP-70... 3 8
LIM domain kinase 2 and LIM domain kinase 1 inhibitor SureCN36... 1 1
Tyrosine-protein kinase Lck and Vascular endothelial growth fa... 1 0
Dihydrofolate reductase and Bifunctional dihydrofolate reducta... 1 4


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00363960 CHEMBL148938 Bioactive AC1LA8VK
CFAMM00363959 CHEMBL23244 Bioactive SRI 8455

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

26229 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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