CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM5482
Family Name Acrosin and Trypsin-1 inhibitor (4-methylphenyl) 4-(diaminomethylideneamino)benzoate family
No. of Seeds 10 No. of Other Members 13
Family Centroid CFAMM00148920 Functional Category Bioactive with Natural Product
Superfamily Amyloid beta A4 protein and Amine oxidase [flavin-containing] A Binder Superfamily
Class Class 281

Cousin Family NamesSeedsMembers
Sodium channel protein type 10 subunit alpha Ligand Tetracaine... 6 166
Histamine H1 receptor Ligand Tranilast Family 5 125
Tumor necrosis factor Inhibitor Cytofab Family 1 10
D(4) dopamine receptor Ligand PD-165167 Family 2 96
Serine protease Inhibitor Camostat Family 1 8
Amine oxidase [flavin-containing] A Inhibitor Ethyl 4-(2-oxo-2... 4 117
Peptidyl-prolyl cis-trans isomerase A Inhibitor 7-amino-4-meth... 4 59
Amyloid beta A4 protein Inhibitor 6-iodo-4'-methylaminoflavone... 3 33
Amine oxidase [flavin-containing] B Inhibitor N-methyl-n-pheny... 6 25
Urotensin-2 receptor Ligand JNJ-28318706 Family 4 227
Carbonic anhydrase 1 and Carbonic anhydrase 2 inhibitor ethyl ... 3 1
Integrin beta-3 and Integrin alpha-2 inhibitor 3-(4-methoxyphe... 4 6
Bifunctional epoxide hydrolase 2 inhibitor 3-[4-[[4-(trifluoro... 5 22
Integrin beta-3 and Integrin alpha-V inhibitor SureCN7379360 f... 2 1
Integrin beta-3 and Integrin alpha-V inhibitor SureCN7458414 f... 2 0
Integrin beta-3 and Integrin alpha-V inhibitor SureCN7496449 f... 3 2
Acrosin and Trypsin-1 inhibitor (4-chlorophenyl) 4-(diaminomet... 2 4
Muscarinic acetylcholine receptor M2 and Muscarinic acetylchol... 10 1
Carbonic anhydrase 2 and Carbonic anhydrase 12 inhibitor F2838... 2 6
Dihydrofolate reductase inhibitor 4-[[4-(4,6-diamino-2,2-dimet... 1 1
Survival motor neuron protein and Nuclear receptor ROR-gamma l... 1 2
Histone deacetylase 1 and Histone deacetylase 2 inhibitor 4-[3... 4 0


External ID

Functional Category

Molecule Name

CFAMM00364128 CHEMBL554140 Bioactive (4-methoxycarbonylphenyl) 4-(diaminomethylideneamino)benzoate;hydrochloride
CFAMM00364120 CHEMBL151747 Bioactive (4-cyanophenyl) 4-(diaminomethylideneamino)benzoate;4-methylbenzenesulfonic acid
CFAMM00364127 CHEMBL539058 Bioactive (4-acetamidophenyl) 4-(diaminomethylideneamino)benzoate;hydrochloride
CFAMM00364119 CHEMBL540096 Bioactive (4-ethoxycarbonylphenyl) 4-(diaminomethylideneamino)benzoate;hydrochloride
CFAMM00364129 CHEMBL542261 Bioactive (3-cyanophenyl) 4-(diaminomethylideneamino)benzoate;hydrochloride

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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